Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Meredith Wolfrom"'
Autor:
Jingsong Cao, Minjung Choi, Eleonora Guadagnin, Maud Soty, Marine Silva, Vincent Verzieux, Edward Weisser, Arianna Markel, Jenny Zhuo, Shi Liang, Ling Yin, Andrea Frassetto, Anne-Renee Graham, Kristine Burke, Tatiana Ketova, Cosmin Mihai, Zach Zalinger, Becca Levy, Gilles Besin, Meredith Wolfrom, Barbara Tran, Christopher Tunkey, Erik Owen, Joe Sarkis, Athanasios Dousis, Vladimir Presnyak, Christopher Pepin, Wei Zheng, Lei Ci, Marjie Hard, Edward Miracco, Lisa Rice, Vi Nguyen, Mike Zimmer, Uma Rajarajacholan, Patrick F. Finn, Gilles Mithieux, Fabienne Rajas, Paolo G. V. Martini, Paloma H. Giangrande
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Glycogen Storage Disease 1a (Gsd1a) is an inherited disorder caused by glucose 6-phosphatase (G6Pase-α) deficiency and characterized by hypoglycaemia and high risk of liver cancer. Here the authors develop a mRNA-based G6Pase-α delivery therapy tha
Externí odkaz:
https://doaj.org/article/977236f43e9f4fb4a8b6a0322537f1cb
Autor:
Kimberly A Coughlan, Rajanikanth J Maganti, Andrea Frassetto, Christine M DeAntonis, meredith Wolfrom, Anne-Renee Graham, Shawn M Hillier, Steven Fortucci, Hoor Al Jandal, Sue-Jean Hong, Paloma H Giangrande, Paolo GV Martini
Publikováno v:
Journal of Biochemical and Clinical Genetics, Vol 2, Iss 1, Pp 28-39 (2019)
Background: Primary Hyperoxaluria Type 1 (PH1) is an inborn error of metabolism caused by mutations in the AGXT gene, which encodes for the hepatocyte-specific enzyme alanine: glyoxylate aminotransferase (AGT). AGT catalyzes the conversion of glyoxyl
Externí odkaz:
https://doaj.org/article/34d2d66e91a546d3a80cafe65ab1b4dd
Autor:
Laurent Dassencourt, Jean-Paul Nicolas, Iris Valtingojer, Meredith Wolfrom, Fabrice Vergne, Stephanie Deprets, Laure Delarbre, Carlos Garcia-Echeverria, Dietmar Hoffmann, Amanda Lennon, Vincent Leroy, Francoise Herve, Emerson Serres, Loreley Calvet
Publikováno v:
Clinical Cancer Research. 18:B47-B47
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily. Activating mutations in ALK are oncogenic and cause 10% to 15% of neuroblastoma cases. Similarly, activating ALK fusions have been detected
Autor:
Maryse Lowinski, Christoph Lengauer, Cedric Barriere, Odette Dos-Santos, Lance Leopold, Pascal Pannier, Isabelle Sanchez, Isabelle Meaux, Hélène Bastien, Nathalie Ratet, Shaomeng Wang, Frederic Fleche, Sophie Besnard, Francis Duffieux, Véronique Lalleman, Laurent Debussche, Christine Delaisi, Meredith Wolfrom, Alexey Rak, Hong Cheng, Dietmar Hoffmann, Dominique De Chalain, Stéphane D'Agostino, Qing Zhou-Liu, James Watters, Dimitri Gorge-Bernat, Stuart Licht, Carlos Garcia-Echeverria, Françoise Bégassat
Publikováno v:
Cancer Research. 72:4648-4648
We have identified two spiro-oxindole-based modulators -compounds A and B- of the MDM2-p53 protein-protein interaction that display suitable pharmacological properties for human clinical testing (1) and a high affinity to the N-terminal domain of hum
Autor:
Carlos Garcia-Echeverria, Vincent Leroy, Meredith Wolfrom, Francoise Herve, Dietmar Hoffmann, Amanda Lennon, Jean-Paul Nicolas, Iris Valtingojer, Laurent Dassencourt, Laure Delarbre, Loreley Calvet
Publikováno v:
Molecular Cancer Therapeutics. 10:B76-B76
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase belonging to the insulin receptor superfamily. Activating mutations in ALK are oncogenic and cause 10 to 15% of neuroblastoma cases. Similarly, activating ALK fusions have been detected i