Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Meredith S. Rocca"'
Autor:
Meredith S. Rocca
Publikováno v:
Developmental and Reproductive Toxicology ISBN: 9780429105234
Developmental and Reproductive Toxicology: A Practical Approach ISBN: 1841848212
Developmental and Reproductive Toxicology: A Practical Approach ISBN: 1841848212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b858b82a49ea44d77b5d17ad6a1fa9a
https://doi.org/10.3109/9781841848211-23
https://doi.org/10.3109/9781841848211-23
Autor:
Karen Davis-Bruno, Neil Chernoff, Wafa Harrouk, Gemma Janer, James H. Kim, Meredith S. Rocca, Ronald D. Hood, Anthony R. Scialli, John M. Rogers, Ulla Liminga, Bengt R. Danielsson, Bruce K. Beyer
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 92:36-51
Workshops on maternal toxicity were held at the annual Society of Toxicology, Teratology Society, and European Teratology Society meetings in 2009. Speakers presented background information prior to a general discussion on this topic. The following r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92d3c03ef9b9b2e565c370c5743e097e
https://doi.org/10.1002/bdrb.20281
https://doi.org/10.1002/bdrb.20281
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:176-203
This report discusses the principles of developmental and reproductive toxicity (DART) testing for biopharmaceuticals. Biopharmaceuticals are large-molecular-weight proteins or peptides produced by modern biotechnology techniques incorporating geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8496ae86a8beec37b568cff9e63bb9
https://doi.org/10.1002/bdrb.20197
https://doi.org/10.1002/bdrb.20197
Autor:
Meredith S. Rocca, Nancy G. Wehner
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:92-97
BACKGROUND: Regulatory guidelines for developmental and reproductive toxicology (DART) studies require selection of “relevant” animal models as determined by kinetic, pharmacological, and toxicological data. Traditionally, rats, mice, and rabbits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d500b99d70df7d40322e3e80d96bdb4b
https://doi.org/10.1002/bdrb.20188
https://doi.org/10.1002/bdrb.20188
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 86:108-116
BACKGROUND: Natalizumab is a humanized monoclonal immunoglobulin G4 antibody directed against the human α4 integrin subunit disrupting interaction with its ligands. As α4 integrins and/or their ligands appear to be involved in reproductive function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0d1a438eef169d195ed95845e98027e
https://doi.org/10.1002/bdrb.20191
https://doi.org/10.1002/bdrb.20191
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 68:421-427
BACKGROUND: Hoshi et al. [Hoshi et al. J Toxicol Sci 10(Suppl):187–255, 1985a,b,c,d] evaluated the potential for hydroxypropyl methylcellulose acetate succinate (HPMCAS) to produce developmental and reproductive toxicity in a series of studies that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94edb9e2ecc7712353cd0e4019b75ef
https://doi.org/10.1002/bdrb.10039
https://doi.org/10.1002/bdrb.10039
Autor:
Margaret M. McCarthy, Meredith S. Rocca, David R. Grattan, Michael Selmanoff, Cathleen A. Sagrillo
Publikováno v:
Endocrinology. 137:4167-4173
gamma-Aminobutyric acid (GABA)ergic neurons terminating in the rostral hypothalamus are stimulated by testosterone. To investigate whether this action is mediated locally through androgen receptors in the rostral hypothalamus, bilateral microcannulas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0271447696cc87129b58092c3d24a669
https://doi.org/10.1210/endo.137.10.8828473
https://doi.org/10.1210/endo.137.10.8828473
Autor:
Michael Selmanoff, Meredith S. Rocca, Kenneth I. Strauss, Margaret M. McCarthy, Cathy A. Sagrillo, David R. Grattan
Publikováno v:
Brain Research. 733:46-55
There is considerable evidence that GABAergic neurons play an important role in the regulation of gonadotropin-releasing hormone (GnRH) secretion, and that these neurons may mediate the feedback actions of gonadal steroids on GnRH neurons. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21b99449523fafdd420ec2c4eacb1ce2
https://doi.org/10.1016/0006-8993(96)00532-x
https://doi.org/10.1016/0006-8993(96)00532-x
Publikováno v:
Hormones and behavior. 30(4)
It is well established that gonadal steroids mediate sexual differentiation of the brain via direct effects on neurons during a restricted critical period. In addition, estrogen can influence glial morphology in the adult brain, and in vitro studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8021458d5c2eddaaa839b3e149198e1a
https://pubmed.ncbi.nlm.nih.gov/9047279
https://pubmed.ncbi.nlm.nih.gov/9047279
Autor:
Meredith S. Rocca
Publikováno v:
Reproductive Toxicology. 28:140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e48fddb209cfbdbb167d741769b8a4
https://doi.org/10.1016/j.reprotox.2009.05.062
https://doi.org/10.1016/j.reprotox.2009.05.062