Výsledky vyhledávání - "Meredith S Irwin"

Akademický článek

COVID‐19: a pandemic experience that illuminates potential reforms to health research

Autor: Hannah N Kozlowski, Michael E Farkouh, Meredith S Irwin, Laszlo G Radvanyi, Aaron D Schimmer, Uri Tabori, Norman D Rosenblum

Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 11, Pp 1-4 (2020)

Abstract COVID‐19 has halted research around the globe and forced researchers out of their laboratories. Non‐emergency medical appointments were canceled. Ongoing clinical trials were challenged to create new modes of operation while public press

Externí odkaz: https://doaj.org/article/562f1d8665274226afee97ac54c94821

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Akademický článek

Diagnostic practices and disease surveillance in Canadian children with congenital central hypoventilation syndrome

Autor: Reshma Amin, Theo J Moraes, Amy Skitch, Meredith S Irwin, Stephen Meyn, Manisha Witmans

Publikováno v: Canadian Respiratory Journal, Vol 20, Iss 3, Pp 165-170 (2013)

OBJECTIVE: To assess the diagnostic and surveillance practices of Canadian pediatric subspecialists for children with congenital central hypoventilation syndrome (CCHS).

Externí odkaz: https://doaj.org/article/bec1a7b3caff44ec977016185ff7d222

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Akademický článek

Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity.

Autor: Alvaro Blanch, Fiona Robinson, Ian R Watson, Lynn S Cheng, Meredith S Irwin

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e66436 (2013)

The p53 family of transcription factors is a key regulator of cell proliferation and death. In this report we identify the eukaryotic translation elongation factor 1-alpha 1 (eEF1A1) to be a novel p53 and p73 interacting protein. Previous studies hav

Externí odkaz: https://doaj.org/article/b25259b0db3446f3a48d144d9e13069b

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Akademický článek

Temporal clustering of neuroblastic tumours in children and young adults from Ontario, Canada

Autor: Louise Hayes, Nermine Basta, Colin R. Muirhead, Jason D. Pole, Paul Gibson, Bruna Di Monte, Meredith S. Irwin, Mark Greenberg, Deborah A. Tweddle, Richard J. Q. McNally

Publikováno v: Environmental Health, Vol 21, Iss 1, Pp 1-8 (2022)

Abstract Background The aetiology of neuroblastic tumours is likely to involve both genetic and environmental factors. A number of possible environmental risk factors have been suggested, including infection. If an irregular temporal pattern in incid

Externí odkaz: https://doaj.org/article/a0e8da9152674a64a60380bb85c96530

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Akademický článek

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation,

Externí odkaz: https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b

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Akademický článek

Alterations in ALK/ROS1/NTRK/MET drive a group of infantile hemispheric gliomas

Autor: Ana S. Guerreiro Stucklin, Scott Ryall, Kohei Fukuoka, Michal Zapotocky, Alvaro Lassaletta, Christopher Li, Taylor Bridge, Byungjin Kim, Anthony Arnoldo, Paul E. Kowalski, Yvonne Zhong, Monique Johnson, Claire Li, Arun K. Ramani, Robert Siddaway, Liana Figueiredo Nobre, Pasqualino de Antonellis, Christopher Dunham, Sylvia Cheng, Daniel R. Boué, Jonathan L. Finlay, Scott L. Coven, Inmaculada de Prada, Marta Perez-Somarriba, Claudia C. Faria, Michael A. Grotzer, Elisabeth Rushing, David Sumerauer, Josef Zamecnik, Lenka Krskova, Miguel Garcia Ariza, Ofelia Cruz, Andres Morales La Madrid, Palma Solano, Keita Terashima, Yoshiko Nakano, Koichi Ichimura, Motoo Nagane, Hiroaki Sakamoto, Maria Joao Gil-da-Costa, Roberto Silva, Donna L. Johnston, Jean Michaud, Bev Wilson, Frank K. H. van Landeghem, Angelica Oviedo, P. Daniel McNeely, Bruce Crooks, Iris Fried, Nataliya Zhukova, Jordan R. Hansford, Amulya Nageswararao, Livia Garzia, Mary Shago, Michael Brudno, Meredith S. Irwin, Ute Bartels, Vijay Ramaswamy, Eric Bouffet, Michael D. Taylor, Uri Tabori, Cynthia Hawkins

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Infant gliomas behave differently to their childhood or adult counterparts. Here, the authors perform a large-scale genetic analysis of these tumours, revealing genetic alterations which may offer therapeutic opportunities.

Externí odkaz: https://doaj.org/article/1dd77b35b12f4fbfa3be4dbd3feb1c2b

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