Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meredith S, Brown"'
Autor:
Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
Externí odkaz:
https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
Autor:
Meredith S Brown, Behnaz Abdollahi, Nevena Ognjenovic, Kristen E Muller, Saeed Hassanpour, Diwakar R Pattabiraman
Publikováno v:
Cancer Research. 82:P4-07
Background: Triple Negative Breast Cancer (TNBC) is an aggressive and heterogeneous subtype characterized by ER/PR/HER2 negative status. Much of the disease potential and aggressive nature of this subtype derives from inter- and intra-tumoral heterog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e9c33dd8bbfeb48eb57db8de35d2f20
https://doi.org/10.1158/1538-7445.sabcs21-p4-07-19
https://doi.org/10.1158/1538-7445.sabcs21-p4-07-19
Autor:
Brenton R Paolella, William J Gibson, Laura M Urbanski, John A Alberta, Travis I Zack, Pratiti Bandopadhayay, Caitlin A Nichols, Pankaj K Agarwalla, Meredith S Brown, Rebecca Lamothe, Yong Yu, Peter S Choi, Esther A Obeng, Dirk Heckl, Guo Wei, Belinda Wang, Aviad Tsherniak, Francisca Vazquez, Barbara A Weir, David E Root, Glenn S Cowley, Sara J Buhrlage, Charles D Stiles, Benjamin L Ebert, William C Hahn, Robin Reed, Rameen Beroukhim
Publikováno v:
eLife, Vol 6 (2017)
Genomic instability is a hallmark of human cancer, and results in widespread somatic copy number alterations. We used a genome-scale shRNA viability screen in human cancer cell lines to systematically identify genes that are essential in the context
Externí odkaz:
https://doaj.org/article/8eec2bdf4b584beabb46e378e18f1d59
Publikováno v:
Methods in cell biology. 171
Tumor heterogeneity presents an ongoing challenge to disease progression and treatment in many solid tumor types. Understanding the roots of intra-tumoral heterogeneity and how it may relate to the high incidence of metastasis is critical in overcomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3ce77a3f8ddee03e773aba24ae85d375
https://pubmed.ncbi.nlm.nih.gov/35953198
https://pubmed.ncbi.nlm.nih.gov/35953198
Autor:
Meredith S. Brown, Behnaz Abdollahi, Owen M. Wilkins, Hanxu Lu, Priyanka Chakraborty, Nevena B. Ognjenovic, Kristen E. Muller, Mohit Kumar Jolly, Brock C. Christensen, Saeed Hassanpour, Diwakar R. Pattabiraman
Publikováno v:
Science advances. 8(31)
The epithelial-to-mesenchymal transition (EMT) is frequently co-opted by cancer cells to enhance migratory and invasive cell traits. It is a key contributor to heterogeneity, chemoresistance, and metastasis in many carcinoma types, where the intermed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f20dcbe14e2cedcab4ad3f02993ee1
https://pubmed.ncbi.nlm.nih.gov/35921406
https://pubmed.ncbi.nlm.nih.gov/35921406
Publikováno v:
Methods in Cell Biology ISBN: 9780323900188
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1246d5320ed6095036dbebf3dd41dd71
https://doi.org/10.1016/bs.mcb.2022.06.003
https://doi.org/10.1016/bs.mcb.2022.06.003
Measuring Health in Jails: Limitations and Opportunities in Measurement of Health-Related Constructs
Publikováno v:
Practicing Anthropology. 41:21-25
Limited research exists concerning measurement issues of health-related constructs among those incarcerated in American jails. This gap in the literature impedes research on health outcomes and health care access among jailed populations and may rend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffd11c20a92ac761de3a6acb32690468
https://doi.org/10.17730/0888-4552.41.4.21
https://doi.org/10.17730/0888-4552.41.4.21
Autor:
Owen M. Wilkins, Saeed Hassanpour, Parijat Chakraborty, Nevena B. Ognjenovic, Diwakar R. Pattabiraman, Behnaz Abdollahi, Mohit Kumar Jolly, Kristen E. Muller, Meredith S. Brown
The Epithelial-to-Mesenchymal Transition (EMT) is a developmental cellular program frequently coopted by cancer cells1 and is a key contributor to both heterogeneity in solid tumors2–4 and later stage chemo-resistance and metastasis5,6. Rather than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d168d62c8c7a6c51153c059d9e7a533a
https://doi.org/10.1101/2021.03.17.434993
https://doi.org/10.1101/2021.03.17.434993
Autor:
Ashton C. Berger, John P. Busanovich, Naomi Curimjee, Hope Wei, Sirano Dhe-Paganon, Jack A. Kosmicki, Meredith S. Brown, Andrew D. Cherniack, Rameen Beroukhim, Galen F. Gao, Brenton R. Paolella, Caitlin A. Nichols, Laura M. Urbanski, William J. Gibson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
Alterations in non-driver genes represent an emerging class of potential therapeutic targets in cancer. Hundreds to thousands of non-driver genes undergo loss of heterozygosity (LOH) events per tumor, generating discrete differences between tumor and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69932bff7bf9743b48a41cd448c169c1
https://doi.org/10.1038/s41467-020-16399-y
https://doi.org/10.1038/s41467-020-16399-y
Autor:
Mohamed Ashick Mohamed Saleem, Meisam Bagheri, Ke Xu, Brock C. Christensen, Youdinghuan Chen, Gadisti Aisha Mohamed, Diwakar R. Pattabiraman, Nevena B. Ognjenovic, Kristen E. Muller, Shivashankar H. Nagaraj, Meredith S. Brown
SummaryDifferentiation therapy is an approach that utilizes our understanding of the hierarchy of cellular systems to pharmacologically induce a shift towards terminal commitment. While this approach has been a paradigm in treating certain hematologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd447ecba361de7605a46974086d2ba2