Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Meredith Roberts-Thomson"'
Autor:
David J. Huggins, Bryn S. Hardwick, Pooja Sharma, Amy Emery, Luca Laraia, Fengzhi Zhang, Ana J. Narvaez, Meredith Roberts-Thomson, Alex T. Crooks, Robert G. Boyle, Richard Boyce, David W. Walker, Natalia Mateu, Grahame J. McKenzie, David R. Spring, Ashok R. Venkitaraman
Publikováno v:
ACS Omega, Vol 5, Iss 1, Pp 822-831 (2019)
Externí odkaz:
https://doaj.org/article/3fe07deb35644870ad3f7fc29a93ca5e
Autor:
Andreas Greth, Shelley Lampkin, Preethi Mayura-Guru, Fleur Rodda, Karen Drysdale, Meredith Roberts-Thomson, Brendan J McMorran, Simon J Foote, Gaétan Burgio
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38999 (2012)
The blood stage of the plasmodium parasite life cycle is responsible for the clinical symptoms of malaria. Epidemiological studies have identified coincidental malarial endemicity and multiple red blood cell (RBC) disorders. Many RBC disorders result
Externí odkaz:
https://doaj.org/article/67b996605d294ebe91ab04436d018963
Autor:
Daniel J Cole, Eeson Rajendra, Meredith Roberts-Thomson, Bryn Hardwick, Grahame J McKenzie, Mike C Payne, Ashok R Venkitaraman, Chris-Kriton Skylaris
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 7, p e1002096 (2011)
The breast cancer suppressor BRCA2 controls the recombinase RAD51 in the reactions that mediate homologous DNA recombination, an essential cellular process required for the error-free repair of DNA double-stranded breaks. The primary mode of interact
Externí odkaz:
https://doaj.org/article/d7e5bba212ce4a52b4caf3a858b0a352
Autor:
David J Huggins, Grahame J McKenzie, Daniel D Robinson, Ana J Narváez, Bryn Hardwick, Meredith Roberts-Thomson, Ashok R Venkitaraman, Guy H Grant, Mike C Payne
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 8, p e1000880 (2010)
The Polo-Like Kinase 1 (PLK1) acts as a central regulator of mitosis and is over-expressed in a wide range of human tumours where high levels of expression correlate with a poor prognosis. PLK1 comprises two structural elements, a kinase domain and a
Externí odkaz:
https://doaj.org/article/ee966ad2698a48b29cd7a8e324340218
Autor:
Ana J. Narvaez, Meredith Roberts-Thomson, Richard J. Boyce, Suzan Ber, Christopher J. Torrance, Alex T. Crooks, Robert George Boyle, Grahame J. McKenzie, David Perera, Samuel P. Barker, Estrella Guarino Almeida, Ian A. Prior, Bryn Hardwick, David J. Huggins, Ashok R. Venkitaraman, David W. Walker, Fiona E. Hood, Roberta Azzarelli, Amy Emery
Publikováno v:
Cell Chemical Biology
Summary Mutations activating KRAS underlie many forms of cancer, but are refractory to therapeutic targeting. Here, we develop Poloppin, an inhibitor of protein-protein interactions via the Polo-box domain (PBD) of the mitotic Polo-like kinases (PLKs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f2f37f22ae1cd96be9703289bb40c
http://hdl.handle.net/11568/1013971
http://hdl.handle.net/11568/1013971
Autor:
R.S. Green, A. M. Crawford, Knowler Kj, G. J. Greer, Penny A Williamson, Meredith Roberts Thomson, John C. McEwan, Ken G. Dodds, Wheeler R, KA Paterson, S.A. Bisset, R.J. Shaw, Cristina Diez Tascon, A. E. Beattie
Publikováno v:
BMC Genomics
BMC Genomics, Vol 7, Iss 1, p 178 (2006)
BMC Genomics, Vol 7, Iss 1, p 178 (2006)
Background Currently most pastoral farmers rely on anthelmintic drenches to control gastrointestinal parasitic nematodes in sheep. Resistance to anthelmintics is rapidly increasing in nematode populations such that on some farms none of the drench fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8608c5916d9a248357285b76aaaeb3aa
https://pubmed.ncbi.nlm.nih.gov/16846521
https://pubmed.ncbi.nlm.nih.gov/16846521
Autor:
Ana J. Narvaez, Bryn Hardwick, Grahame J. McKenzie, Meredith Roberts-Thomson, Mike C. Payne, Guy H. Grant, David J. Huggins, Ashok R. Venkitaraman, Daniel D. Robinson
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 8 (2010)
PLoS Computational Biology
PLoS Computational Biology
The Polo-Like Kinase 1 (PLK1) acts as a central regulator of mitosis and is over-expressed in a wide range of human tumours where high levels of expression correlate with a poor prognosis. PLK1 comprises two structural elements, a kinase domain and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10412a7269aa56572c5f9246e08da255
https://doi.org/10.1371/journal.pcbi.1000880
https://doi.org/10.1371/journal.pcbi.1000880