Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Meredith N. Frazier"'
Publikováno v:
FEBS Open Bio, Vol 12, Iss 9, Pp 1567-1583 (2022)
Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS‐CoV‐2 pande
Externí odkaz:
https://doaj.org/article/4f34b159ad4f4aff82ea99ddef73b102
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and mole
Externí odkaz:
https://doaj.org/article/3b3bd68422cc4508a02721056de1a082
Autor:
Meredith N. Frazier, Isha M. Wilson, Juno M. Krahn, Kevin John Butay, Lucas B. Dillard, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nucleic Acids Res
Coronaviruses generate double-stranded (ds) RNA intermediates during viral replication that can activate host immune sensors. To evade activation of the host pattern recognition receptor MDA5, coronaviruses employ Nsp15, which is a uridine-specific e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfa419dff28c4a17f6ffe328c90ac4b4
https://pubmed.ncbi.nlm.nih.gov/35262076
https://pubmed.ncbi.nlm.nih.gov/35262076
Publikováno v:
Curr Opin Struct Biol
The production of ribosomes is essential for ensuring the translational capacity of cells. Because of its high energy demand ribosome production is subject to stringent cellular controls. Hundreds of ribosome assembly factors are required to facilita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c41ea1c2971c8dad3e7b14b346b3352
https://doi.org/10.1016/j.sbi.2020.09.003
https://doi.org/10.1016/j.sbi.2020.09.003
Global sequencing efforts from the ongoing COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, continue to provide insight into the evolution of the viral genome. Coronaviruses encode 16 nonstructural proteins, within the first two-thirds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2736d629b2bd3ff2214b0e8c7d6c160
https://doi.org/10.1101/2022.05.10.491349
https://doi.org/10.1101/2022.05.10.491349
Autor:
Mario J. Borgnia, Leesa J. Deterding, Robin E. Stanley, Lucas B. Dillard, Juno M. Krahn, Monica C. Pillon, Lalith Perera, Isha M Wilson, Jason Williams, Zachary D. Stewart, Meredith N Frazier
Nsp15 is a uridine specific endoribonuclease that coronaviruses employ to cleave viral RNA and evade host immune defense systems. Previous structures of Nsp15 from across Coronaviridae revealed that Nsp15 assembles into a homo-hexamer and has a conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d29d1330e1e81e5cf908f6dcc3034c3
https://doi.org/10.1101/2021.06.01.446181
https://doi.org/10.1101/2021.06.01.446181
Autor:
Lucas B. Dillard, Cassandra K. Hayne, Meredith N Frazier, Lalith Perera, Robin E. Stanley, Allen L. Hsu, Leesa J. Deterding, Jason Williams, Zachary D. Stewart, Mario J. Borgnia, Jacob Gordon, Venkata P. Dandey, Monica C. Pillon, Mack Sobhany, Seda Kocaman, Juno M. Krahn
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd88fa61a41e36bf913df39126d8bfb
Publikováno v:
Crit Rev Biochem Mol Biol
HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding) RNases are an emerging class of functionally diverse RNA processing and degradation enzymes. Members are defined by a small α-helical bundle encompassing a short consensus RNase motif. HEPN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9348a4fcaecc25ee569f085bea50a3
https://pubmed.ncbi.nlm.nih.gov/33349060
https://pubmed.ncbi.nlm.nih.gov/33349060
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681bcbdd8d24dd78f6f58a25417f339
https://pubmed.ncbi.nlm.nih.gov/33504779
https://pubmed.ncbi.nlm.nih.gov/33504779
Autor:
Peng Xu, Boyang Xie, Elad Binshtein, Rodger Burcham, Meredith N. Frazier, Todd R. Graham, Amy Kendall, Terunaga Nakagawa, Jue Wang, Hui Wei, Lauren P. Jackson
In metazoans, retromer (VPS26/VPS35/VPS29) associates with sorting nexin (SNX) proteins to form coats on endosomal tubules and sort cargo proteins to the trans-Golgi network (TGN) or plasma membrane. This core complex is highly conserved from yeast t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae8b2b25fbce69cab1aeed865998d8f
https://doi.org/10.1101/639575
https://doi.org/10.1101/639575