Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Meredith L. Stone"'
Autor:
Stacy K. Thomas, Max M. Wattenberg, Shaanti Choi-Bose, Mark Uhlik, Ben Harrison, Heather Coho, Christopher R. Cassella, Meredith L. Stone, Dhruv Patel, Kelly Markowitz, Devora Delman, Michael Chisamore, Jeremy Drees, Nandita Bose, Gregory L. Beatty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could
Externí odkaz:
https://doaj.org/article/83508be0427a42c987caca447a63c531
Autor:
Meredith L. Stone, Jesse Lee, Veronica M. Herrera, Kathleen Graham, Jae W. Lee, Austin Huffman, Heather Coho, Evan Tooker, Max I. Myers, Michael Giannone, Yan Li, Thomas H. Buckingham, Kristen B. Long, Gregory L. Beatty
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for antitumor T cell immunity. However, treatment with anti-CD40 is commonly accompanied by both systemic cytokine release and liver trans
Externí odkaz:
https://doaj.org/article/a6e788afd3834015b4e4f598ab882751
Autor:
Cynthia A. Zahnow, Robert A. Casero, Stephen B. Baylin, Meredith L. Stone, Jackson R. Foley, Kurtis E. Bachman, Karla R. Wiehagen, Cassandra E. Holbert, Matthew Dunworth, Stephen M. Brown, Meghan Travers
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFNγ+ T cells and natural kil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4be1bc7f2b0b5d91d58f1fd6f863a0
https://doi.org/10.1158/0008-5472.c.6510837.v1
https://doi.org/10.1158/0008-5472.c.6510837.v1
Autor:
Cynthia A. Zahnow, Robert A. Casero, Stephen B. Baylin, Meredith L. Stone, Jackson R. Foley, Kurtis E. Bachman, Karla R. Wiehagen, Cassandra E. Holbert, Matthew Dunworth, Stephen M. Brown, Meghan Travers
Supplementary data including polyamine levels, addition of anti-PD-1 to therapy, and flow cytometry plots.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::387a8abf8c0d525ec7845d74e8b2e651
https://doi.org/10.1158/0008-5472.22421085.v1
https://doi.org/10.1158/0008-5472.22421085.v1
Autor:
Meredith L. Stone, Jesse Lee, Jae W. Lee, Heather Coho, Max M. Wattenberg, Hana Choi, Veronica M. Hererra, Yuqing Xue, Shaanti Choi-Bose, Vinod Balachandran, Gregory L. Beatty
Publikováno v:
Cancer Research. 83:2888-2888
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease for which the 5-year survival rate is about 10%. Rare long-term survivors after surgical resection have been characterized as having high quality immune responses to primary tu
Publikováno v:
Cancer Research. 82:B014-B014
Metastasis remains the primary cause of mortality in cancer. This is especially true in pancreatic ductal adenocarcinoma (PDAC) - where the liver is the most common site of metastasis and the 5-year overall survival rate for these patients has remain
Autor:
Michael A. Giannone, Austin P. Huffman, Kristen B. Long, Max I Myers, Meredith L. Stone, Jesse Lee, Jae W. Lee, Veronica M. Herrera, Gregory L. Beatty, Kathleen Graham, Evan Tooker, Thomas H. Buckingham, Yan Li, Heather Coho
Publikováno v:
JCI Insight
Agonist CD40 antibodies are under clinical development in combination with chemotherapy as an approach to prime for anti-tumor T cell immunity. However, treatment with anti-CD40 is commonly accompanied by both systemic cytokine release and liver tran
Autor:
Meredith L. Stone, Kurtis E. Bachman, Cynthia A. Zahnow, Stephen B. Baylin, Jackson R. Foley, Matthew Dunworth, Cassandra E. Holbert, Karla R. Wiehagen, Robert A. Casero, Meghan Travers, Stephen M. Brown
Publikováno v:
Cancer Res
Although ovarian cancer has a low incidence rate, it remains the most deadly gynecologic malignancy. Previous work has demonstrated that the DNMTi 5-Azacytidine (5AZA-C) activates type I interferon signaling to increase IFNγ+ T cells and natural kil
Autor:
Dong Xin, Ailing Ji, Austin L. Chien, Meredith L. Stone, Kathleen Graham, Maria C. de Beer, Ramesh K. Ramanathan, Jae W. Lee, Mitesh J. Borad, Taylor A. Black, Krishna S. Majmundar, Mark H. O'Hara, Devora Delman, Stephanie S. Yee, Stacy K. Thomas, Mingming Gao, Joey H. Li, Abraham Shaked, Paige M. Porrett, Dexi Liu, Xia Hua, Erica L. Carpenter, Whitney L. Gladney, Gregory L. Beatty, Frederick C. de Beer, Charu Aggarwal, Chad A. Komar, Jeffrey C. Thompson, Nancy R. Webb
Publikováno v:
Nature
The liver is the most common site of metastatic disease1. Although this metastatic tropism may reflect the mechanical trapping of circulating tumour cells, liver metastasis is also dependent, at least in part, on the formation of a 'pro-metastatic' n
Autor:
Stacy K. Thomas, Shaanti Choi-Bose, Heather Coho, Christopher Casella, Meredith L. Stone, Max M. Wattenberg, Gregory L. Beatty
Publikováno v:
Cancer Research. 82:5633-5633
Introduction: For most patients with pancreatic ductal adenocarcinoma (PDAC), metastatic disease is the main cause of mortality with the liver being the most common site of metastasis. In the liver, macrophages are the most abundant immune cell subse