Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Meredith J Layton"'
Autor:
Chin Wee Tan, Bruce S Gardiner, Yumiko Hirokawa, Meredith J Layton, David W Smith, Antony W Burgess
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31882 (2012)
Wnt/β-catenin signalling regulates cell fate, survival, proliferation and differentiation at many stages of mammalian development and pathology. Mutations of two key proteins in the pathway, APC and β-catenin, have been implicated in a range of can
Externí odkaz:
https://doaj.org/article/3d0faf9c37c74058b3b4431f183af786
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e14127 (2010)
The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin
Externí odkaz:
https://doaj.org/article/ba3adb8721fb4be1bc6e31d721ffba2d
Autor:
Anthony W Burgess, Meredith J. Layton, Rommel A. Mathias, Eugene A. Kapp, Richard J. Simpson, Maree C. Faux, Justin Wee Eng Lim, Hong Ji
Publikováno v:
ELECTROPHORESIS. 33:1873-1880
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene are common in both inherited and sporadic forms of colorectal cancer (CRC), and are associated with dysregulated Wnt signaling. Colon carcinoma SW480 cells restored with stable e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1121580bf8f7315d60f6aed89d4a824
https://doi.org/10.1002/elps.201100687
https://doi.org/10.1002/elps.201100687
Autor:
Maree C. Faux, Richard J. Simpson, Eugene A. Kapp, Meredith J. Layton, Hong Ji, Nicole Church, Robert J. A. Goode, Antony W. Burgess
Publikováno v:
ELECTROPHORESIS. 33:1804-1813
β-catenin is a member of the armadillo repeat family of proteins and has important functions in cell-cell adhesion and Wnt signalling. Different protein species of β-catenin have been shown to exist in the cell and the relative proportions of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3bc8decfdbe6ba862e1208231bfcbfc
https://doi.org/10.1002/elps.201100671
https://doi.org/10.1002/elps.201100671
Autor:
Parvin Rahman, Absorn Sriratana, Rajendra Gurung, Hidetoshi Takada, Fenny Wiradjaja, Jennifer M Dyson, Richard D Huysmans, Meredith J. Layton, David A. Sheffield, Christina Anne Mitchell, Lisa M Ooms, Tony Tiganis
Publikováno v:
Journal of Biological Chemistry. 286:29758-29770
Phosphoinositide 3-kinase (PI3K) regulates cell polarity and migration by generating phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P(3)) at the leading edge of migrating cells. The serine-threonine protein kinase Akt binds to PI(3,4,5)P(3), resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d0c1c111d69d5a34414a0c91929129
https://doi.org/10.1074/jbc.m111.263103
https://doi.org/10.1074/jbc.m111.263103
Autor:
Jennifer M Dyson, Meredith J. Layton, Steven Petratos, Lauren C. Binge, Adam R. Cole, Christina Anne Mitchell, Lisa M Ooms, Calum Sutherland, Megan Victoria Astle
Publikováno v:
Journal of Biological Chemistry. 286:23407-23418
Neuron polarization is essential for the formation of one axon and multiple dendrites, establishing the neuronal circuitry. Phosphoinositide 3-kinase (PI3K) signaling promotes axon selection and elongation. Here we report in hippocampal neurons siRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5871853c7de2309057229bc5406373
https://doi.org/10.1074/jbc.m110.214247
https://doi.org/10.1074/jbc.m110.214247
Autor:
Michael D. Waterfield, John E. Ladbury, Kate Hilyard, Paul Rugman, Ronan O'Brien, Paul C. Driscoll, Meredith J. Layton, Raj Handa, Debora Renzoni
Publikováno v:
Protein Science. 9:570-579
The issue of specificity in tyrosine kinase intracellular signaling mediated by src homology 2 (SH2) domains has great importance in the understanding how individual signals maintain their mutual exclusivity and affect downstream responses. Several p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9114cf6f66a400b9c5023a992dd5fd50
https://doi.org/10.1110/ps.9.3.570
https://doi.org/10.1110/ps.9.3.570
Autor:
Meredith J. Layton, Anthony W Burgess, Janine L Coates, Stephen H. Cody, Andrew H. A. Clayton, Maree C. Faux, Bruno Catimel
Publikováno v:
Oncogene. 27:5808-5820
The adenomatous polyposis coli (APC) tumour suppressor is a multifunctional protein involved in the regulation of Wnt signalling and cytoskeletal dynamics. Little is known about how APC controls these disparate functions. In this study, we have used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9813a7d6d5ac4813dad92fbc7d34aa8c
https://doi.org/10.1038/onc.2008.205
https://doi.org/10.1038/onc.2008.205
Publikováno v:
Biochemical Journal. 401:569-579
The MNK (Menkes disease protein; ATP7A) is a major copper- transporting P-type ATPase involved in the delivery of copper to cuproenzymes in the secretory pathway and the efflux of excess copper from extrahepatic tissues. Mutations in the MNK (ATP7A)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff0b7c3a5870533884a965f05ce6ae3
https://doi.org/10.1042/bj20060924
https://doi.org/10.1042/bj20060924
Autor:
Meredith J. Layton, Joan K. Heath, Stephen H. Cody, Edouard C. Nice, Sue D. Xiang, M H C Lam, Emanuela Handman, J E Layton
Publikováno v:
Journal of Microscopy. 217:265-274
Current optical methods to collect Nomarski differential interference contrast (DIC) or phase images with a transmitted light detector (TLD) in conjunction with confocal laser scanning microscopy (CLSM) can be technically challenging and inefficient.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf51200d6c4d654197448461d49c9218
https://doi.org/10.1111/j.1365-2818.2005.01452.x
https://doi.org/10.1111/j.1365-2818.2005.01452.x