Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Meredith Hazen"'
Autor:
Kimberly K. Kajihara, Homer Pantua, Hilda Hernandez-Barry, Meredith Hazen, Kiran Deshmukh, Nancy Chiang, Rachana Ohri, Erick R. Castellanos, Lynn Martin, Marissa L. Matsumoto, Jian Payandeh, Kelly M. Storek, Kellen Schneider, Peter A. Smith, Michael F. T. Koehler, Siao Ping Tsai, Richard Vandlen, Kelly M. Loyet, Gerald Nakamura, Thomas Pillow, Dhaya Seshasayee, Sharookh B. Kapadia, Wouter L. W. Hazenbos
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Antibiotic treatment of life-threatening P. aeruginosain vitroP. aeruginosa
Externí odkaz:
https://doaj.org/article/55553da6bf96462684a50c1126fff190
Autor:
Cong, Wu, Ryan, Cook, Ping, Wu, Neha, Srikumar, Elin, Chee, William S, Sawyer, Hua, Wang, Meredith, Hazen, Isidro, Hotzel, Elsa-Noah, N'Diaye, Ning, Ding, Yichin, Liu, John C, Tran, Zhengmao, Ye
Publikováno v:
Analytical and Bioanalytical Chemistry. 414:6601-6610
Proteases are critical proteins involved in cleaving substrates that may impact biological pathways, cellular processes, or disease progression. In the biopharmaceutical industry, modulating the levels of protease activity is an important strategy fo
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ebbf88322d045b6d0c4b08c2c22021d
https://doi.org/10.1158/1535-7163.c.6537960.v1
https://doi.org/10.1158/1535-7163.c.6537960.v1
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Figure S1. Validation of anti-GFRA1 antibodies (R&D systems and GNE-8H6) for the use of Immunohistochemistry (IHC) analysis; Figure S2. ELISA analyses to test binding specificity of anti-GFRA1 antibodies to GFRA1 (A) and GFRA2 (B) extra cellular doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a6557ca8c0f2a229a1ced8e41d71e
https://doi.org/10.1158/1535-7163.22505118
https://doi.org/10.1158/1535-7163.22505118
Autor:
Tulika Tyagi, Elsa-Noah N’Diaye, Robert J. Newman, Hua Wang, Ping Wu, Merone Roose-Girma, Cong Wu, Zhengmao Ye, Paul J. Wolters, Ryan Cook, Dhaya Seshasayee, Wei Yu Lin, Meredith Hazen, Isidro Hötzel, Lucinda Tam, Ryan LaCanna, Ning Ding
Publikováno v:
American journal of physiology. Cell physiology. 320(2)
Proteolytic processing of procollagens is a central step during collagen fibril formation. Bone morphogenic protein 1 (BMP1) is a metalloprotease that plays an important role in the cleavage of carboxy-terminal (COOH-terminal) propeptides from procol
Autor:
Brett Marshall, Dana C. Andersen, Max L. Tejada, Wilson Phung, Robert F. Kelley, Qian Gong, Jean-Michel Vernes, Athena W. Wong, Qinglin Ou, Y. Gloria Meng, Susan Crowell, Meredith Hazen
Publikováno v:
mAbs. 8:1098-1106
For some antibodies intended for use as human therapeutics, reduced effector function is desired to avoid toxicities that might be associated with depletion of target cells. Since effector function(s), including antibody-dependent cell-mediated cytot
Autor:
Sunil Bhakta, Lisa M. Crocker, Yvonne Chen, Meredith Hazen, Melissa M. Schutten, Dongwei Li, Coenraad Kuijl, Rachana Ohri, Fiona Zhong, Kirsten A. Poon, Mary Ann T. Go, Eric Cheng, Robert Piskol, Ron Firestein, Aimee Fourie-O'Donohue, Katherine R. Kozak, Helga Raab, Jo-Anne Hongo, Deepak Sampath, Mark S. Dennis, Richard H. Scheller, Paul Polakis, Jagath R. Junutula
Publikováno v:
Molecular Cancer Therapeutics. 18:2182-2182
Autor:
Ron Firestein, Yvonne Chen, Rachana Ohri, Richard H. Scheller, Helga Raab, Katherine R. Kozak, Paul Polakis, Coenraad Kuijl, Dongwei Li, Meredith Hazen, Lisa Crocker, Robert Piskol, Mark S. Dennis, Jagath Reddy Junutula, Eric Cheng, Deepak Sampath, Kirsten Achilles Poon, Aimee Fourie-O'Donohue, Sunil Bhakta, Fiona Zhong, Melissa Schutten, Mary Ann T. Go, Jo-Anne Hongo
Publikováno v:
Bhakta, S, Crocker, L M, Chen, Y, Hazen, M, Schutten, M M, Li, D, Kuijl, C, Ohri, R, Zhong, F, Poon, K A, Go, M A T, Cheng, E, Piskol, R, Firestein, R, Fourie-O'Donohue, A, Kozak, K R, Raab, H, Hongo, J-A, Sampath, D, Dennis, M S, Scheller, R H, Polakis, P & Junutula, J R 2018, ' An anti-gdnf family receptor alpha 1 (gfra1 antibody–drug conjugate for the treatment of hormone receptor–positive breast cancer ', Molecular Cancer Therapeutics, vol. 17, no. 3, pp. 638-649 . https://doi.org/10.1158/1535-7163.MCT-17-0813
Molecular Cancer Therapeutics, 17(3), 638-649. American Association for Cancer Research Inc.
Molecular Cancer Therapeutics, 17(3), 638-649. American Association for Cancer Research Inc.
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Autor:
Bing Li, Jagath Reddy Junutula, Karen E. Ervin, Meredith Hazen, Dara Y. Kallop, Jo-Anne Hongo, Vicki Chiang, Rajesh Vij, Robby M. Weimer, Bijay S. Jaiswal, Richard H. Scheller, Steven Randle, Paul Polakis, Sunil Bhakta, Isidro Hötzel
Publikováno v:
mAbs. 6:95-107
Multi-transmembrane proteins are especially difficult targets for antibody generation largely due to the challenge of producing a protein that maintains its native conformation in the absence of a stabilizing membrane. Here, we describe an immunizati
Autor:
Xiumin Wu, Hai Ngu, Min Xu, David F. Choy, Karin Reif, Arna Katewa, Elizabeth Luis, Jianyong Wang, Cary D. Austin, Meijuan Zhou, Wyne P. Lee, Tao Huang, Nandhini Ramamoorthi, Yongchang Shi, Meredith Hazen, Mercedesz Balazs, Erick R. Castellanos, Donghong Yan, Zhonghua Lin, Marissa L. Matsumoto, Yonglei Shang, Jo-Anne Hongo, Jian Payandeh, Joseph R. Arron, Isidro Hötzel, Margaret Solon
Publikováno v:
JCI Insight. 1
Eosinophilic inflammation and Th2 cytokine production are central to the pathogenesis of asthma. Agents that target either eosinophils or single Th2 cytokines have shown benefits in subsets of biomarker-positive patients. More broadly effective treat