Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Meredith Ferrante"'
Autor:
Valerie J. Whiterock, Amy Easton, Regina Miller, Lawrence R. Marcin, Meredith Ferrante, Bradley C. Pearce, John B. Hogan, Joanne J. Bronson, Clotilde Bourin, Mendi A. Higgins, Robert G. Gentles, F. Christopher Zusi, Walter Kostich, John E. Macor, Michael Gulianello, Min Ding, Linda J. Bristow, Adam Hendricson, Kim A. Johnson, Andrew Alt, Yanling Huang, Matthew A. Seager
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:496-513
Triazolopyridine ethers with mGlu2 positive allosteric modulator (PAM) activity are disclosed. The synthesis, in vitro activity, and metabolic stability data for a series of analogs is provided. The effort resulted in the discovery of a potent, selec
Autor:
Zhi Liang, Alan Wilson, Li Dong, Neil T. Burford, David S. Kimball, Kenneth G. Carson, Yingzhi Bi, Yulian Zhang, Bireshwar Dasgupta, Carolyn Diane Dzierba, Richard A. Hartz, James E. Grace, G. Greg Zipp, Soojin Kwon, Martin A. Lewis, Joanne J. Bronson, Cynthia Anne Fink, Amr Nouraldeen, Saadat Aleem, Giovanni Cianchetta, Jiancheng Wang, Ying Liu, Vijay T. Ahuja, Robert L. Bertekap, Jianxin Han, Michael Alan Green, Angela Cacace, Godwin Kumi, Yudith Garcia, Ying Qiao, Meredith Ferrante, John E. Macor, Ryan Westphal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1448-1452
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs
Autor:
Regina Miller, Michele Matchett, Nicholas J. Lodge, Yulia Benitex, Thaddeus F. Molski, Wendy Clarke, John E. Macor, Rulin Zhao, Robert Zaczek, Linda J. Bristow, Amy Easton, Christiana I. Iwuagwu, JoAnne E Natale, Haiquan Fang, Ronald J. Knox, Baoqing Ma, F. Christopher Zusi, Siva Digavalli, James H. Cook, Matthew D. Hill, Francine L. Healy, Debra J. Post-Munson, Jingfang Qian Cutrone, Daniel G. Morgan, Bei Wang, Richard E. Olson, Qi Gao, Rex Denton, Robert A. Mate, Ivar M. McDonald, Dalton King, Meredith Ferrante, Kimberley A. Lentz, Kelli M. Jones, Judith A. Siuciak, Lizbeth Gallagher
Publikováno v:
Journal of medicinal chemistry. 59(24)
The design and synthesis of a series of quinuclidine-containing spirooxazolidines (“spiroimidates”) and their utility as α7 nicotinic acetylcholine receptor partial agonists are described. Selected members of the series demonstrated excellent se
Autor:
Ivar M. McDonald, Robert A. Mate, Debra J. Post-Munson, Meredith Ferrante, David G. Harden, Lizbeth Gallagher, Richard E. Olson, F. Christopher Zusi, Barbara J. Robertson, Steven I. Dworetzky, Daniel G. Morgan, Hong Huang, Ronald J. Knox, Nicholas J. Lodge, John E. Macor, Robert L. Bertekap
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1684-1688
High throughput screening led to the identification of a novel series of quinolone α7 nicotinic acetylcholine receptor (nAChR) agonists. Optimization of an HTS hit (1) led to 4-phenyl-1-(quinuclidin-3-ylmethyl)quinolin-2(1H)-one, which was found to
Autor:
Mendi A, Higgins, Lawrence R, Marcin, F, Christopher Zusi, Robert, Gentles, Min, Ding, Bradley C, Pearce, Amy, Easton, Walter A, Kostich, Matthew A, Seager, Clotilde, Bourin, Linda J, Bristow, Kim A, Johnson, Regina, Miller, John, Hogan, Valerie, Whiterock, Michael, Gulianello, Meredith, Ferrante, Yanling, Huang, Adam, Hendricson, Andrew, Alt, John E, Macor, Joanne J, Bronson
Publikováno v:
Bioorganicmedicinal chemistry. 25(2)
Triazolopyridine ethers with mGlu
Autor:
John J. Herbst, Meredith Ferrante, Annapurna Pendri, Kristin L. Rockwell, Jonathan O’Connell, Susan Jenkins, James Loy, Chi Shing Sum, Adam Hendricson, Martyn Banks, Robert G. Gentles, Yulia Benitex, Robert L. Bertekap, Neil T. Burford, Mary Ellen Cvijic, John E. Macor, Andrew Alt, Litao Zhang, Ryan Westphal, Jing Chen, Michelle Nophsker, Guo Li
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(2)
The muscarinic acetylcholine receptor subtype 1 (M1) receptors play an important role in cognition and memory, and are considered to be attractive targets for the development of novel medications to treat cognitive impairments seen in schizophrenia a
Autor:
Michael R. Weed, Jeffrey M. Brown, Brett R. Beno, Ryan S. Westphal, Robert G. Gentles, John Watson, Yan Kong, Lisa Hunihan, Martin A. Lewis, Mary Ellen Cvijic, John E. Macor, Joanne J. Bronson, Meredith Ferrante, Thaddeus F. Molski, Ronald J. Knox, Andrew Alt, Angela Cacace, Kristin L. Rockwell, Shuanghua Hu, Adam Hendricson, Yazhong Huang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 354(3)
The present studies represent the first published report of a dopamine D1 positive allosteric modulator (PAM). D1 receptors have been proposed as a therapeutic target for the treatment of cognitive deficits associated with schizophrenia. However, the
Autor:
Yanling Huang, Neil T. Burford, Andrew Alt, Meredith Ferrante, Jim Myslik, Ronald J. Knox, Debra Hong, Ryan Westphal, Chris Ferrante, Ed Hunnicutt, Nelly Masias, Litao Zhang, John Watson, Robert L. Bertekap, Michele Matchett, Adam Hendricson, Walt Kostich
Publikováno v:
Journal of laboratory automation. 17(2)
Prosecution of positive allosteric modulator (PAM) targets demands a specialized assay toolset. Many GPCR or ion channel targets are adaptable to functional assays whereby PAM efficacy can be inferred from left or rightward shifts in the concentratio
Autor:
Tony Paiva, Svetlana Tertyshnikova, Meredith Ferrante, Litao Zhang, Wilson Z. Shou, Steve Spence, Adam Hendricson, Deborah Post-Munson, Ronald J. Knox, Mike Krambis, Liz Gallagher, Michele Matchett
Publikováno v:
Assay and drug development technologies. 10(2)
Low-volume dispensing of neat dimethyl sulfoxide (DMSO) into plate-based assays conserves compound, assay reagents, and intermediate dilution plate cost and, as we demonstrate here, significantly improves structure-activity relationship resolution. A
Autor:
Christian D. Ferrante, Moneesh Chatterjee, Lynda S. Cook, John E. Leet, Elizabeth A. Dumas, Martyn Banks, David A. Stock, John G. Houston, Normand J. Cloutier, Meredith Ferrante, William E. Monahan, Sandra L. Matson, John Watson
Publikováno v:
Journal of biomolecular screening. 14(5)
Preserving the integrity of the compound collection and providing high-quality materials for drug discovery in an efficient and cost-effective manner are 2 major challenges faced by compound management (CM) at Bristol-Myers Squibb (BMS). The demands