Výsledky vyhledávání - "Meredith Crosby"

In vitro and in vivo mammalian mutation assays support a nonmutagenic mechanism of carcinogenicity for hydrazine

Autor: John Nicolette, Alison Kondratiuk, Meredith Crosby, Paul Sonders, Joel Murray

Publikováno v: Environmental and Molecular Mutagenesis. 62:4-17

Hydrazine has been described as a mutagenic, probable human carcinogen. It is mutagenic in in vitro systems such as bacterial reverse mutation (Ames) tests and some yeast systems, as well as in in vivo systems with drosophila. It was shown to cause c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a94467341eac707fef7b1012b723a11
https://doi.org/10.1002/em.22406

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Nonclinical safety assessment of epigenetic modulatory drugs: Current status and industry perspective

Autor: Junguo Zhou, Paul Butler, Meredith Crosby, Laura Aschenbrenner, Jim Blank, Jonathan G. Moggs, Vincent L. Reynolds, Kyle L. Kolaja, Derek D. Best, Dana Shuey, Matthew M. Abernathy, Terry R. Van Vleet, Chelsea Snyder, Patricia A. Escobar, Timothy K. Hart, Laura Custer

Publikováno v: Regulatory toxicology and pharmacology : RTP. 117

Pharmaceutic products designed to perturb the function of epigenetic modulators have been approved by regulatory authorities for treatment of advanced cancer. While the predominant effort in epigenetic drug development continues to be in oncology, no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0c03ba3f1ed7746ed6a53efdd5ecdd
https://pubmed.ncbi.nlm.nih.gov/32911461

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Akademický článek

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Autor: Elena Favaro, Anassuya Ramachandran, Robert McCormick, Harriet Gee, Christine Blancher, Meredith Crosby, Cecilia Devlin, Christopher Blick, Francesca Buffa, Ji-Liang Li, Borivoj Vojnovic, Ricardo Pires das Neves, Peter Glazer, Francisco Iborra, Mircea Ivan, Jiannis Ragoussis, Adrian L Harris

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e10345 (2010)

Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondri

Externí odkaz: https://doaj.org/article/4b262f404a274363b024a45e2a841996

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A comparison of 24 chemicals in the six-well bacterial reverse mutation assay to the standard 100-mm Petri plate bacterial reverse mutation assay in two laboratories

Autor: John Nicolette, Alison Kondratiuk, G. Jayakumar, Paul Sonders, Meredith Crosby, A. Patel, Emily Dakoulas, Joel Murray, Kamala Pant, R. Vicente, K. Datta, M. Mathur, Rohan Kulkarni, Kyle L. Kolaja

Publikováno v: Regulatory toxicology and pharmacology : RTP. 100

The bacterial reverse mutation assay (Ames) is a fundamental genetic toxicology test, and efforts to miniaturize the regulatory GLP version are essential in assessing genotoxic liabilities earlier in the drug development pipeline. Two versions of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623336ead26e589cf83fdf5be3a0b00a
https://pubmed.ncbi.nlm.nih.gov/30401633

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Weak silica nanomaterial-induced genotoxicity can be explained by indirect DNA damage as shown by the OGG1-modified comet assay and genomic analysis

Autor: Meredith Crosby, Yuching Shan, Thomas R. Downs, Stefan Pfuhler, Ashley Allemang

Publikováno v: Mutagenesis. 32(1)

In a previous study, 15-nm silica nanoparticles (NPs) caused small increases in DNA damage in liver as measured in the in vivo comet and micronucleus assays after intravenous administration to rats at their maximum tolerated dose, a worst-case exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c43c28cac6c09fb220a1e65afd54cf8
https://pubmed.ncbi.nlm.nih.gov/27864332

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