Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Meredith A McKean"'
Autor:
Jordi Rodon Ahnert, Brian Schulte, Michael J. Demeure, Dustin Deming, Noah Federman, Meredith A. McKean, Elizabeth Lee, Alexander Spira, David J. Kwiatkowski, Maen Hussein, Erlinda Gordon, David Crockett, Kristen Ganjoo, Lee D. Cranmer, Anita N. Schmid, Willis H. Navarro, Loretta M. Itri, Gopa Iyer
Publikováno v:
Cancer Research. 83:CT057-CT057
nab-Sirolimus is a novel albumin-bound mTOR inhibitor (mTORi) approved in the US for adult patients with malignant PEComa. In an exploratory analysis of the pivotal AMPECT trial of nab-sirolimus in advanced malignant PEComa (NCT02494570), 8/9 (89%) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::642b0fafe03034aa67ce8dcaf19ab603
https://doi.org/10.1158/1538-7445.am2023-ct057
https://doi.org/10.1158/1538-7445.am2023-ct057
Autor:
Nehal Lakhani, Kristi Manjarrez, Meredith Ann McKean, Amita Patnaik, Stanford L. Peng, Z. Goldberg, Michael Chisamore, Hany Zayed
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundDespite successes with checkpoint inhibition (CPI) in a wide range of tumors, most patients demonstrate primary or acquired resistance, thus driving the need for better IO therapy. Research has suggested that CPI therapy exerts much of its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66159c265009304b5790e4a1882e687
https://doaj.org/article/bca090b5f31f495ba34cdc8392c3e9f4
https://doaj.org/article/bca090b5f31f495ba34cdc8392c3e9f4
Autor:
Alice S Bexon, Hendrik-Tobias Arkenau, Jeff Evans, Gerald S Falchook, Stefan N Symeonides, Meredith A McKean, Elisa Fontana, Manojkumar Bupath, Alistair McLaren, Sreenivasa Chandana, Tze-en Ding, Emerson A Lim, Jim Rotolo, Gina Capiaux, Rob Michel, Stephen Kaesshaefer, Nehal J Lakhani
Publikováno v:
Cancer Research. 82:OT2-01
Background: CCAAT/Enhancer Binding Protein Beta (C/EBPβ) is a transcription factor that is active during embryofetal development but held in an inactive state in most mature cells. C/EBPβ is upregulated or overactivated in multiple cancers, where i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cdaaa9dd97572ef228c63bff28d7197
https://doi.org/10.1158/1538-7445.sabcs21-ot2-01-01
https://doi.org/10.1158/1538-7445.sabcs21-ot2-01-01
Autor:
Rodabe N. Amaria, Meredith Ann McKean
Publikováno v:
American Journal of Clinical Dermatology. 19:639-646
Locally advanced and metastatic melanoma have historically had poor survival outcomes. Long-term follow-up of both targeted therapies and immune checkpoint inhibitors has confirmed the survival benefit of these agents in stage IV melanoma, and recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950f4ffc0f7c12a620d4e47d7579b1b1
https://doi.org/10.1007/s40257-018-0371-8
https://doi.org/10.1007/s40257-018-0371-8
Autor:
Nehal J. Lakhani, Hendrik-Tobias Arkenau, Stefan N. Symeonides, Jeffry Evans, Meredith A. McKean, Elisa Fontana, Manojkumar Bupath, Alistair McLaren, Sreenivasa Chandana, Tze-en Ding, Emerson A. Lim, Jim Rotolo, Gina Capiaux, Rob Michel, Stephen Kaesshaefer, Alice S. Bexon, Gerald S. Falchook
Publikováno v:
Molecular Cancer Therapeutics. 20:P06-03
Introduction: The oncogenic transcription factor CCAAT/enhancer-binding protein β (C/EBPβ) is normally active in embryofetal development, but inactive and suppressed in mature cells. Upregulation or activation of C/EBPβ in cancer promotes tumor su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e40672c27fb67b751aaff365656c3d5
https://doi.org/10.1158/1535-7163.targ-21-p06-03
https://doi.org/10.1158/1535-7163.targ-21-p06-03
Autor:
Rodabe N. Amaria, Meredith Ann McKean
Publikováno v:
Clinical Skin Cancer. 2:32-38
Treatment strategies in metastatic melanoma have attempted to use the immune system to target cancer since the 1980s. Adoptive cell transfer using autologous tumor-infiltrating lymphocytes (TILs) extracted from a patient tumor and cultured in vitro w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f079e1cb994ec8b6fa9dac66b5d6f9
https://doi.org/10.1016/j.clsc.2017.10.001
https://doi.org/10.1016/j.clsc.2017.10.001
Autor:
Laura Sierra, Tom Zimmerman, Shiraj Sen, Melinda S. Merchant, Jessica Ainscough, Jay Yang, Meredith Ann McKean, Anthony Hamlett, Sant P. Chawla
Publikováno v:
Journal of Clinical Oncology. 38:TPS11573-TPS11573
TPS11573 Background: Epithelioid sarcoma (ES) is characterized by loss of inhibitor of integrase 1 (INI1), allowing enhancer of zeste homologue 2 (EZH2) to repress cell differentiation and promote tumorigenesis. Tazemetostat (TAZ) is an EZH2 inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dda961107a4c7dc4f0ebc84a063d378
https://doi.org/10.1200/jco.2020.38.15_suppl.tps11573
https://doi.org/10.1200/jco.2020.38.15_suppl.tps11573
Autor:
Alan E. Siroy, Junsheng Ma, Alexander J. Lazar, Phuong Vo, Scott E. Woodman, Fernando Carapeto, Mariana Petaccia de Macedo, Keyur P. Patel, Katherine G. Roth, Agda Karina Eterovic, Junna Oba, Roland L. Bassett, Elizabeth A. Grimm, Meredith Ann McKean, David S. Hong, Lauren E. Haydu, Wei Lien Wang
Publikováno v:
The Journal of investigative dermatology. 139(3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e688a2459932143b7ad62ae410a8c64
https://pubmed.ncbi.nlm.nih.gov/30798855
https://pubmed.ncbi.nlm.nih.gov/30798855
Autor:
Junna, Oba, Sun-Hee, Kim, Wei-Lien, Wang, Mariana P, Macedo, Fernando, Carapeto, Meredith A, McKean, John, Van Arnam, Agda K, Eterovic, Shiraj, Sen, Charuta R, Kale, Xiaoxing, Yu, Cara L, Haymaker, Mark, Routbort, Lauren E, Haydu, Chantale, Bernatchez, Alexander J, Lazar, Elizabeth A, Grimm, David S, Hong, Scott E, Woodman
Publikováno v:
JCO precision oncology. 2018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c3123a15935027ee088dc8c58bfead9
https://pubmed.ncbi.nlm.nih.gov/30094412
https://pubmed.ncbi.nlm.nih.gov/30094412
Autor:
Rodabe N. Amaria, Meredith Ann McKean
Publikováno v:
Cancer treatment reviews. 70
Stage III melanoma encompasses a range of disease burdens, including microscopic foci of metastatic melanoma in a sentinel lymph node; bulky, clinically detected lymphadenopathy; and in-transit dermal metastases. After initial surgical management, pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378874e91bab548a72433968c90ea0dd
https://pubmed.ncbi.nlm.nih.gov/30195813
https://pubmed.ncbi.nlm.nih.gov/30195813