Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Meredith A, Skiba"'
Autor:
Edward P. Harvey, Jung-Eun Shin, Meredith A. Skiba, Genevieve R. Nemeth, Joseph D. Hurley, Alon Wellner, Ada Y. Shaw, Victor G. Miranda, Joseph K. Min, Chang C. Liu, Debora S. Marks, Andrew C. Kruse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Off-target binding hinders the development of therapeutic antibodies and reproducibility in basic research settings. Here the authors develop a method to quantify and reduce the polyreactivity of antibody fragments based on protein sequence alone.
Externí odkaz:
https://doaj.org/article/9f15c88fe2344995bf186f5732b9be87
Publikováno v:
ACS chemical biology. 17(8)
Installation of methyl groups can significantly improve the binding of small-molecule drugs to protein targets; however, site-selective methylation often presents a significant synthetic challenge. Metal- and
Publikováno v:
ACS Chemical Biology. 17:2088-2098
Autor:
Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, Foldit Players, University of Michigan students, Zoran Popović, David Baker, Firas Khatib, James C. A. Bardwell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure,
Externí odkaz:
https://doaj.org/article/b15fb233272548d7bc0404a5bf35e26f
Autor:
Andrew N. Dates, Daniel T.D. Jones, Meredith A. Skiba, Maggie M. Burruss, Andrew C. Kruse, Stephen C. Blacklow
Adhesion G Protein-Coupled Receptors (aGPCRs) are a distinct family of transmembrane proteins that carry out numerous cellular functions in multicellular organisms. During maturation, aGPCRs undergo autoproteolysis to generate non-covalently associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::972d5bcc1ae9832d214a96646d83a649
https://doi.org/10.1101/2022.07.14.500097
https://doi.org/10.1101/2022.07.14.500097
Construction and remodeling of the bacterial peptidoglycan (PG) cell wall must be carefully coordinated with cell growth and division. Central to cell wall construction are hydrolases that cleave bonds in peptidoglycan. These enzymes also represent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0636b6444dfacb2883839ed7c5d239
https://doi.org/10.1101/2022.01.21.477235
https://doi.org/10.1101/2022.01.21.477235
Autor:
Wayne L. Hubbell, Andrew C. Kruse, Robert J. Lefkowitz, Conor McMahon, Howard A. Rockman, Matthias Elgeti, Laura M. Wingler, Jialu Wang, Meredith A. Skiba, Dean P. Staus
Publikováno v:
Proc Natl Acad Sci U S A
There is considerable interest in developing antibodies as functional modulators of G protein-coupled receptor (GPCR) signaling for both therapeutic and research applications. However, there are few antibody ligands targeting GPCRs outside of the che
Autor:
Meredith A. Skiba, Jacob R. Anderson, Hayden R. Schmidt, Daniel A. Greenfield, Andrew C. Kruse, Michael Mandler, Piotr Sliz
Publikováno v:
ACS Medicinal Chemistry Letters. 11:1555-1561
The σ1 receptor is a transmembrane protein implicated in several pathophysiological conditions, including neurodegenerative disease (J. Pharmacol. Sci.2015127 (1), 1729), drug addiction (Behav. Pharmacol.201627 (2-3 Spec Issue), 10015), cancer (Hand
Autor:
Robert J. Lefkowitz, Alissa L. W. Kleinhenz, Meredith A. Skiba, Andrew C. Kruse, Carl-Mikael Suomivuori, Conor McMahon, Dean P. Staus, Ron O. Dror, Naomi R. Latorraca, Laura M. Wingler
Publikováno v:
Science
Choosing the drug to fit the protein Many approved drugs bind to G protein–coupled receptors (GPCRs). A challenge in targeting GPCRs is that different ligands preferentially activate different signaling pathways. Two papers show how biased signalin
Autor:
Scott Horowitz, Brian Koepnick, Raoul Martin, Agnes Tymieniecki, Amanda A. Winburn, Seth Cooper, Jeff Flatten, David S. Rogawski, Nicole M. Koropatkin, Tsinatkeab T. Hailu, Neha Jain, Philipp Koldewey, Logan S. Ahlstrom, Matthew R. Chapman, Andrew P. Sikkema, Meredith A. Skiba, Finn P. Maloney, Felix R. M. Beinlich, Foldit Players, University of Michigan students, Zoran Popović, David Baker, Firas Khatib, James C. A. Bardwell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-2 (2016)
Nature Communications 7: Article number:12549 (2016); Published 16 September 2016; Updated 25 October 2016 The original version of this Article contained an error in the spelling of a member of the University of Michigan students Consortium, Sam Lee,
Externí odkaz:
https://doaj.org/article/1232003cb40a496181d47d61db72f8c2