Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Meredith, O'Keeffe"'
Autor:
Ethan P. Oxley, Nadia J. Kershaw, Cynthia Louis, Katharine J. Goodall, Maximilian M. Garwood, Skye Min Jee Ho, Veronica T.F. Voo, Hae-Young Park, Josephine Iaria, Lilian L.L. Wong, Ariel G. Lebenbaum, Stephanie Wiranata, Ee Shan Pang, Emily S.J. Edwards, Damian B. D’Silva, Jacinta Hansen, Menno C. van Zelm, Meredith O’Keeffe, P. Mark Hogarth, Nicole M. Haynes, Nicholas D. Huntington, Ian P. Wicks, Ross A. Dickins
Publikováno v:
Cell Reports, Vol 43, Iss 10, Pp 114834- (2024)
Summary: T cell surface CTLA4 sequesters the costimulatory ligands CD80 and CD86 on antigen-presenting cells (APCs) to prevent autoimmunity. Therapeutic immunosuppression by recombinant CTLA4-immunoglobulin (Ig) fusion proteins, including abatacept,
Externí odkaz:
https://doaj.org/article/6c8609b2d6c447c2abb2c3c69d1e33ba
Autor:
Rajan Venkatraman, Katherine R. Balka, Wilson Wong, Jananipriya Sivamani, Zoe Magill, Kirsteen M. Tullett, Rachael M. Lane, Tahnee L. Saunders, Maximilien Tailler, Peter J. Crack, Linda M. Wakim, Mireille H. Lahoud, Kate E. Lawlor, Benjamin T. Kile, Meredith O’Keeffe, Dominic De Nardo
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110693- (2024)
Summary: The cGAS-STING pathway responds to cytosolic DNA to elicit host immunity to infection. The activation of stimulator of interferon genes (STING) can trigger a number of critical cellular responses including inflammation, noncanonical autophag
Externí odkaz:
https://doaj.org/article/4f6ffb7d172c46ffbb14376dc21aae1e
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
Runqiu Song, Mariam Bafit, Kirsteen M. Tullett, Peck Szee Tan, Mireille H. Lahoud, Meredith O’Keeffe, Anthony W. Purcell, Asolina Braun
Publikováno v:
Methods and Protocols, Vol 7, Iss 2, p 20 (2024)
The generation of bone-marrow-derived dendritic cells is a widely used approach in immunological research to study antigen processing and presentation, as well as T-cell activation responses. However, the initial step of isolating the bone marrow can
Externí odkaz:
https://doaj.org/article/542cc4b101824deaaea3f74857518e9f
Autor:
Winfrey Hoo, Ms, Jennifer Payne, Dr, Julien Tailhades, Dr, Jemma Gullick, Ms, Rachel Cass, Ms, Ee Shan Pang, Dr, Meredith O'Keeffe, Dr, Felix Ellett, Dr, Alex Fulcher, Dr, Daniel Irima, Dr, Anton Peleg, Professor, Max Cryle, Dr
Publikováno v:
Journal of Global Antimicrobial Resistance, Vol 31, Iss , Pp S24- (2022)
Externí odkaz:
https://doaj.org/article/1074261ebcba4d90934a75af0f41ffdc
Autor:
Ee Shan Pang, Ghazal Daraj, Katherine R. Balka, Dominic De Nardo, Christophe Macri, Hubertus Hochrein, Kelly-Anne Masterman, Peck S. Tan, Angus Shoppee, Zoe Magill, Nazneen Jahan, Mariam Bafit, Yifan Zhan, Benjamin T. Kile, Kate E. Lawlor, Kristen J. Radford, Mark D. Wright, Meredith O’Keeffe
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Stimulator of Interferon Genes (STING) is a cytosolic sensor of cyclic dinucleotides (CDNs). The activation of dendritic cells (DC) via the STING pathway, and their subsequent production of type I interferon (IFN) is considered central to eradicating
Externí odkaz:
https://doaj.org/article/70cc408876864abf9485d6da1eda5714
Autor:
Kirsteen M Tullett, Peck Szee Tan, Hae-Young Park, Ralf B Schittenhelm, Nicole Michael, Rong Li, Antonia N Policheni, Emily Gruber, Cheng Huang, Alex J Fulcher, Jillian C Danne, Peter E Czabotar, Linda M Wakim, Justine D Mintern, Georg Ramm, Kristen J Radford, Irina Caminschi, Meredith O'Keeffe, Jose A Villadangos, Mark D Wright, Marnie E Blewitt, William R Heath, Ken Shortman, Anthony W Purcell, Nicos A Nicola, Jian-Guo Zhang, Mireille H Lahoud
Publikováno v:
eLife, Vol 9 (2020)
The dendritic cell receptor Clec9A facilitates processing of dead cell-derived antigens for cross-presentation and the induction of effective CD8+ T cell immune responses. Here, we show that this process is regulated by E3 ubiquitin ligase RNF41 and
Externí odkaz:
https://doaj.org/article/ce7301ac4e2c47ffba46b495f1882e5b
The Influence of Antibiotic Resistance on Innate Immune Responses to Staphylococcus aureus Infection
Publikováno v:
Antibiotics, Vol 11, Iss 5, p 542 (2022)
Staphylococcus aureus (S. aureus) causes a broad range of infections and is associated with significant morbidity and mortality. S. aureus produces a diverse range of cellular and extracellular factors responsible for its invasiveness and ability to
Externí odkaz:
https://doaj.org/article/7eee7247aa57436e834e8d811d5b5538
Autor:
Tabinda Hussain, Angela Nguyen, Carmel Daunt, Daniel Thiele, Ee Shan Pang, Jasmine Li, Aidil Zaini, Meredith O’Keeffe, Colby Zaph, Nicola L. Harris, Kylie M. Quinn, Nicole L. La Gruta
Publikováno v:
The Journal of Immunology. 210:297-309
CD8 virtual memory T (TVM) cells are Ag-naive CD8 T cells that have undergone partial differentiation in response to common γ-chain cytokines, particularly IL-15 and IL-4. TVM cells from young individuals are highly proliferative in response to TCR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::757c2983290e9ea21a345cb9db0beeac
https://doi.org/10.4049/jimmunol.2200316
https://doi.org/10.4049/jimmunol.2200316
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Malaria remains a serious threat to global health. Sustained malaria control and, eventually, eradication will only be achieved with a broadly effective malaria vaccine. Yet a fundamental lack of knowledge about how antimalarial immunity is acquired
Externí odkaz:
https://doaj.org/article/85efeda2197649e788b5ba6abf8ada4d