Výsledky vyhledávání - "Merdad Parsey"

Abstract CT203: Report of a first-in-human study of the first-in-class fatty acid synthase (FASN) inhibitor TVB-2640

Autor: Daniel D. Von Hoff, William McCulloch, Manish Patel, Valentina Zhukova-Harrill, Suzanne F. Jones, Merdad Parsey, Andrew Brenner, George Kemble, Jeffrey R. Infante, Howard A. Burris

Publikováno v: Cancer Research. 75:CT203-CT203

FASN inhibition is a novel approach to cancer treatment involving the selective disruption of palmitate biosynthesis that, in tumor cells, causes changes in cell signaling, sensitivity to chemotherapeutic agents, and apoptosis in addition to other ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25fa294f3c45ee1efce5ae19fc509781
https://doi.org/10.1158/1538-7445.am2015-ct203

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CD40 Contributes to Lethality in Acute Sepsis: In Vivo Role for CD40 in Innate Immunity

Autor: Jeffrey A. Gold, Satomi Hoshino, Michael D. Weiden, Doris B. Tse, Anna Nolan, Merdad Parsey, Yoshihiko Hoshino, Herman Yee

Sepsis induces an early inflammatory cascade initiated by the innate immune response. This often results in the development of multisystem organ failure. We examined the role of CD40, a costimulatory molecule that is integral in adaptive immunity, by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c8779c48274c8b1a44356f1ce3f768
https://europepmc.org/articles/PMC155725/