Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mercy Otteng"'
Autor:
Zhong Li, Judy Lucas, Jonathan D. Bloom, Russell Dushin, Hao Liu, Mercy Otteng, Mark Johnson, Thomas Nittoli, Jeremy I. Levin, Andrea Olland, Jennifer M. Golas, Christoph W. Zapf, Erik Vogan, Antonia A. Nikitenko, Frank Boschelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4602-4607
An extension of our previously reported series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. Addition of a second methyl group to the tether provided analogs that show increased potency in binding as well as cell-proliferation ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292118865b349b233211d45dbcb33006
https://doi.org/10.1016/j.bmcl.2011.05.102
https://doi.org/10.1016/j.bmcl.2011.05.102
Autor:
Charles Ingalls, Christoph W. Zapf, Hao Liu, Thomas Nittoli, Judy Lucas, Erik Vogan, Jamie L. McBean, Russell Dushin, Mercy Otteng, Jeremy I. Levin, Frank Boschelli, Yongbo Hu, Jennifer M. Golas, Bloom Jonathan David
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3411-3416
A novel series of macrocyclic ortho-aminobenzamide Hsp90 inhibitors is reported. In continuation of our research in this area, macrocyclic amides and lactams were explored to reduce the risk of hERG liabilities. This effort culminated in the discover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e86ec59ece02b676d71192cfd60f61
https://doi.org/10.1016/j.bmcl.2011.03.112
https://doi.org/10.1016/j.bmcl.2011.03.112
Autor:
Hwei-Ru Tsou, Mercy Otteng, Tritin Tran, M. Brawner Floyd Jr., Marvin Reich, Gary Birnberg, Kristina Kutterer, Semiramis Ayral-Kaloustian, Malini Ravi, Ramaswamy Nilakantan, Mary Grillo, John P. McGinnis, Sridhar K. Rabindran
Publikováno v:
Journal of Medicinal Chemistry; May2008, Vol. 51 Issue 12, p3507-3525, 19p