The interplay between NF-kappaB and E2F1 coordinately regulates inflammation and metabolism in human cardiac cells.

Autor: Xavier Palomer, David Álvarez-Guardia, Mercy M Davidson, Tung O Chan, Arthur M Feldman, Manuel Vázquez-Carrera

Publikováno v: PLoS ONE, Vol 6, Iss 5, p e19724 (2011)

Pyruvate dehydrogenase kinase 4 (PDK4) inhibition by nuclear factor-κB (NF-κB) is related to a shift towards increased glycolysis during cardiac pathological processes such as cardiac hypertrophy and heart failure. The transcription factors estroge

Externí odkaz: https://doaj.org/article/304fbede2b5345609576dd025b629f32

Supplementary Table 1 from Arsenic Induced Mitochondrial DNA Damage and Altered Mitochondrial Oxidative Function: Implications for Genotoxic Mechanisms in Mammalian Cells

Autor: Tom K. Hei, Mercy M. Davidson, Evelyn Hernandez-Rosa, Sarah X.L. Huang, Michael A. Partridge

Supplementary Table 1 from Arsenic Induced Mitochondrial DNA Damage and Altered Mitochondrial Oxidative Function: Implications for Genotoxic Mechanisms in Mammalian Cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ede00bd48d6407fbc66e9ed79be812b
https://doi.org/10.1158/0008-5472.22368240.v1

SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation

Autor: Xavier Palomer, Javier Pizarro-Delgado, Manuel Vázquez-Carrera, A Planavila, Irene Miguel-Escalada, Francesc Villarroya, M. Silvia Román-Azcona, Raquel García, J. Francisco Nistal, Brenda Valenzuela-Alcaraz, Emma Barroso, Jorge Ferrer, Fatima Crispi, Mercy M. Davidson, Álvaro Sepúlveda-Martínez

Publikováno v: Signal Transduction and Targeted Therapy
Dipòsit Digital de la UB
Universidad de Barcelona
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-10 (2020)

Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b561c897191d82f3f8492e4ab6e63cb
http://hdl.handle.net/10044/1/79328

PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells

Autor: Xavier Palomer, Manuel Vázquez-Carrera, Eva Capdevila-Busquets, Emma Barroso, Laia Salvadó, Gaia Botteri, Walter Wahli, Liliane Michalik, Mercy M. Davidson

Publikováno v: International Journal of Cardiology. 174:110-118

Background: Chronic endoplasmic reticulum (ER) stress contributes to the apoptotic cell death in the myocardium, thereby playing a critical role in the development of cardiomyopathy. ER stress has been reported to be induced after high-fat diet feedi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59ecaf798e6bff353b3a63b1e8293e2
https://doi.org/10.1016/j.ijcard.2014.03.176

Sex differences in exercise-induced physiological myocardial hypertrophy are modulated by oestrogen receptor beta

Autor: Jan-Åke Gustafsson, Christina Westphal, Renée Ventura-Clapier, Carola Schubert, Joachim Leber, Maryline Moulin, Elke Dworatzek, Vera Regitz-Zagrosek, Angelika Kusch, Duska Dragun, Daniela Fliegner, Shokoufeh Mahmoodzadeh, Mercy M. Davidson, Georgios Kararigas

Publikováno v: Cardiovascular Research. 102:418-428

Aims Oestrogen receptor alpha (ERα) and beta (ERβ) are involved in the regulation of pathological myocardial hypertrophy (MH). We hypothesize that both ER are also involved in physiological MH. Therefore, we investigated the role of ER in exercise-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8bd2103ae6a4b359ef56269ca041f54
https://doi.org/10.1093/cvr/cvu065