Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Mercy Gohil"'
Autor:
Sangya Agarwal, Angela Aznar Gomez, Tong Da, Shunichiro Kuramitsu, Weimin Kong, Pranali Ravikumar, Mercy Gohil, Megan M. Davis, Joseph A. Fraietta, Gabriela Plesa, David L. Porter, Regina M. Young, Carl H. June
Publikováno v:
Cancer Research. 82:5571-5571
The field of cancer immunotherapy has led to successful treatments such as monoclonal antibodies (MAb), inhibitory receptor (IR) blockade, and adoptive cell transfer (ACT). ACT modified to express chimeric antigen receptors (CARs) can redirect T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b43678d2f8847cb3cbde40b8d7921083
https://doi.org/10.1158/1538-7445.am2022-5571
https://doi.org/10.1158/1538-7445.am2022-5571
Autor:
Vivek, Narayan, Julie S, Barber-Rotenberg, In-Young, Jung, Simon F, Lacey, Andrew J, Rech, Megan M, Davis, Wei-Ting, Hwang, Priti, Lal, Erica L, Carpenter, Shannon L, Maude, Gabriela, Plesa, Neha, Vapiwala, Anne, Chew, Michael, Moniak, Ronnie A, Sebro, Michael D, Farwell, Amy, Marshall, Joan, Gilmore, Lester, Lledo, Karen, Dengel, Sarah E, Church, Tyler D, Hether, Jun, Xu, Mercy, Gohil, Thomas H, Buckingham, Stephanie S, Yee, Vanessa E, Gonzalez, Irina, Kulikovskaya, Fang, Chen, Lifeng, Tian, Kyle, Tien, Whitney, Gladney, Christopher L, Nobles, Hayley E, Raymond, Elizabeth O, Hexner, Donald L, Siegel, Frederic D, Bushman, Carl H, June, Joseph A, Fraietta, Bruce L, Levine
Publikováno v:
Nature medicine. 28(4)
Chimeric antigen receptor (CAR) T cells have demonstrated promising efficacy, particularly in hematologic malignancies. One challenge regarding CAR T cells in solid tumors is the immunosuppressive tumor microenvironment (TME), characterized by high l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a7bb7fa879c20cb8e11ab244db1c24b2
https://pubmed.ncbi.nlm.nih.gov/35411068
https://pubmed.ncbi.nlm.nih.gov/35411068
Autor:
Matthew E. Johnson, Renee M. Cotton, E. John Wherry, Shannon A. Carty, Andrew D. Wells, Lauren B. Banks, Martha S. Jordan, Mercy Gohil, Erietta Stelekati, Gary A. Koretzky
Publikováno v:
The Journal of Immunology. 200:82-91
T cell differentiation requires appropriate regulation of DNA methylation. In this article, we demonstrate that the methylcytosine dioxygenase ten-eleven translocation (TET)2 regulates CD8+ T cell differentiation. In a murine model of acute viral inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25296991fdcc33c42d1979300b6941a2
https://doi.org/10.4049/jimmunol.1700559
https://doi.org/10.4049/jimmunol.1700559
Autor:
Joseph A. Fraietta, C. June, January Salas-Mckee, Anne Lamontagne, Andrew D. Fesnak, Don L. Siegel, Vanessa E. Gonzalez, Mercy Gohil, Julie K. Jadlowsky, Whitney L. Gladney, Edward A. Stadtmauer, Jun Xu, Mark M. Davis, Bruce L. Levine, Simon F. Lacey
Publikováno v:
Cytotherapy. 22:S35-S36
Background & Aim NY-ESO-1 is a cancer testis antigen with ectopic expression on multiple myeloma (MM), melanoma and sarcoma but restricted expression on normal tissues, rendering it a good candidate target for cancer immunotherapy. We recently report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390cb4d4f80b9be5fd6fdc5294fce8a4
https://doi.org/10.1016/j.jcyt.2020.03.027
https://doi.org/10.1016/j.jcyt.2020.03.027
Autor:
A. Dai, Simon F. Lacey, Vanessa E. Gonzalez, Don L. Siegel, Kathleen M. Haines, Jun Xu, Aarti Jain, Regina M. Young, K. Gabunia, Fang Chen, Irina Kulikovskaya, John Scholler, R.M. Leskowitz, N. Koterba, Anne Chew, J.S. McKee, Carl H. June, D. Hasenmayer, B.L. Levine, J. Rojas Levine, Gabriela Plesa, S. Mackey, Mark M. Davis, Minnal Gupta, Mercy Gohil, P. Eby
Publikováno v:
Cytotherapy. 23:S160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3534cfc857936eae15ab5636c25a340
https://doi.org/10.1016/s1465324921005491
https://doi.org/10.1016/s1465324921005491
Autor:
E. Fox, Don L. Siegel, Mercy Gohil, A. Dai, D. Holland, Mark M. Davis, Edward Pequignot, Kathleen M. Haines, Jun Xu, B.L. Levine, I. Sassoon, Gabriela Plesa, Aarti Jain, F. Alvarado, Julie K. Jadlowsky
Publikováno v:
Cytotherapy. 23:S178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1aa77020c73f324416eabbf208635a
https://doi.org/10.1016/s1465324921005831
https://doi.org/10.1016/s1465324921005831
Autor:
Iulian Pruteanu-Malinici, Alina C. Boesteanu, Noelle V. Frey, Felipe Bedoya, Jennifer Brogdon, Don L. Siegel, Changfeng Zhang, F. Brad Johnson, Megan M. Davis, Edward Pequignot, Regina M. Young, Simon F. Lacey, Yan Wang, David L. Porter, Roddy S. O’Connor, Carl H. June, Sadik H. Kassim, Wei-Ting Hwang, David E Ambrose, Lifeng Tian, Joseph A. Fraietta, Corin L. Dorfmeier, Stefan Lundh, Bruce L. Levine, Jun Xu, Hans Bitter, Fang Chen, Irina Kulikovskaya, Nicholas Wilcox, Mercy Gohil, Harit Parakandi, Alexander C. Huang, E. John Wherry, Li Liu, J. Joseph Melenhorst, Elena Orlando, Minnal Gupta
Publikováno v:
Nature Medicine. 27:561-561
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fdbbc013a9884b7f454f421a988e602
https://doi.org/10.1038/s41591-021-01248-2
https://doi.org/10.1038/s41591-021-01248-2
Autor:
R.M. Leskowitz, Julie K. Jadlowsky, Gabriela Plesa, Anne Chew, Simon F. Lacey, Don L. Siegel, Andrew D. Fesnak, January Salas-Mckee, Mercy Gohil, Mark M. Davis, Whitney L. Gladney, Elizabeth O. Hexner, Jun Xu, A. Dai, Carl H. June
Publikováno v:
Cytotherapy. 22:S35
Background & Aim Data from a recent clinical trial at the University of Pennsylvania (UPenn) demonstrate the safety of NYCE T cells, which are autologous, patient-derived T cells transduced with lentivirus to express NY-ESO-1 T cell receptor and mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d402823310fe8b40a0ac10d9eb26d49d
https://doi.org/10.1016/j.jcyt.2020.03.026
https://doi.org/10.1016/j.jcyt.2020.03.026
Autor:
Simon F. Lacey, Jamie E. DeNizio, Shantan Reddy, Rahul M. Kohli, Stefan Lundh, Irina Kulikovskaya, Jennifer J.D. Morrissette, Shelley L. Berger, Joseph A. Fraietta, Morgan A. Sammons, Yangbing Zhao, Alexandria P. Cogdill, Mercy Gohil, Marvin H. Gee, David L. Porter, Yan Wang, Enrique Lin-Shiao, Christopher L. Nobles, Xiaojun Liu, J. Joseph Melenhorst, Martha S. Jordan, David E Ambrose, Bruce L. Levine, Shannon A. Carty, Michael Kalos, Regina M. Young, Katherine A. Alexander, Frederic D. Bushman, Katherine T. Marcucci, Farzana Nazimuddin, Minnal Gupta, John K. Everett, Carl H. June, Jun Xu, K. Christopher Garcia, Fang Chen, Young Hwang, Tyler J. Reich
Cancer immunotherapy based on genetically redirecting T cells has been used successfully to treat B cell malignancies1-3. In this strategy, the T cell genome is modified by integration of viral vectors or transposons encoding chimaeric antigen recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d9594ff7433f45db65c0b1c37925dc
https://europepmc.org/articles/PMC6320248/
https://europepmc.org/articles/PMC6320248/
Autor:
Lifeng Tian, Joseph A. Fraietta, Jun Xu, Hans Bitter, Carl H. June, Iulian Pruteanu-Malinici, Edward Pequignot, Alina C. Boesteanu, Roddy S. O’Connor, Changfeng Zhang, Noelle V. Frey, Corin L. Dorfmeier, F. Brad Johnson, Simon F. Lacey, Nicholas Wilcox, Bruce L. Levine, Sadik H. Kassim, Stefan Lundh, Harit Parakandi, E. John Wherry, Megan M. Davis, J. Joseph Melenhorst, Regina M. Young, David L. Porter, Wei-Ting Hwang, Yan Wang, Felipe Bedoya, Alexander C. Huang, David E Ambrose, Li Liu, Mercy Gohil, Jennifer Brogdon, Elena Orlando, Don L. Siegel, Fang Chen, Irina Kulikovskaya, Minnal Gupta
Tolerance to self-antigens prevents the elimination of cancer by the immune system1,2. We used synthetic chimeric antigen receptors (CARs) to overcome immunological tolerance and mediate tumor rejection in patients with chronic lymphocytic leukemia (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab21abca5e0308fecf5fa6ee68f9d55
https://europepmc.org/articles/PMC6117613/
https://europepmc.org/articles/PMC6117613/