Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mercy, Ramanjulu"'
Autor:
William Fried, Mrityunjay Tyagi, Leonid Minakhin, Gurushankar Chandramouly, Taylor Tredinnick, Mercy Ramanjulu, William Auerbacher, Marissa Calbert, Timur Rusanov, Trung Hoang, Nikita Borisonnik, Robert Betsch, John J. Krais, Yifan Wang, Umeshkumar M. Vekariya, John Gordon, George Morton, Tatiana Kent, Tomasz Skorski, Neil Johnson, Wayne Childers, Xiaojiang S. Chen, Richard T. Pomerantz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The DNA damage response (DDR) protein DNA Polymerase θ (Polθ) is synthetic lethal with homologous recombination (HR) factors and is therefore a promising drug target in BRCA1/2 mutant cancers. We discover an allosteric Polθ inhibitor (Pol
Externí odkaz:
https://doaj.org/article/a588334634d94054a3dac469d64b47e7
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-11 (2020)
Abstract Background The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP m
Externí odkaz:
https://doaj.org/article/3bd2ff0d998342d19730ea8e87c87f91
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/0885133593dd45429fe0ee1d3c01dcf3
Autor:
Wayne E. Childers, Paul M. Dunman, Benjamin E. Blass, Magid Abou-Gharbia, Jeffrey D. Rothstein, Lizhen Wu, Svetlana Vidensky, John Gordon, Lori A. Knackstedt, Mercy Ramanjulu
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 378:51-59
Cocaine use disorder currently lacks Food and Drug Administration–approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17aa1fbd57dd9f15bede5511d390fd2b
https://doi.org/10.1124/jpet.121.000532
https://doi.org/10.1124/jpet.121.000532
Autor:
Lori A, Knackstedt, Lizhen, Wu, Jeffrey, Rothstein, Svetlana, Vidensky, John, Gordon, Mercy, Ramanjulu, Paul, Dunman, Benjamin, Blass, Wayne, Childers, Magid, Abou-Gharbia
Publikováno v:
J Pharmacol Exp Ther
Cocaine use disorder currently lacks Food and Drug Administration–approved treatments. In rodents, the glutamate transporter-1 (GLT-1) is downregulated in the nucleus accumbens after cocaine self-administration, and increasing the expression and fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2a5481c2900a3ff0c98f936df011b5c
https://pubmed.ncbi.nlm.nih.gov/33986035
https://pubmed.ncbi.nlm.nih.gov/33986035
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-11 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-11 (2020)
Background The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d817cfabd4ac2c43f1e1db51ab056b18
https://doi.org/10.1186/s13024-019-0350-4
https://doi.org/10.1186/s13024-019-0350-4
Autor:
Jamallamudi Rajasekhar, Wayne E. Childers, Shalini Paliwal, John W. Ellingboe, Ramreddy Bobbala, L. Krishnakanth Reddy, Pravin Iyer, George Morton, Boruwa Joshodeep, Magid Abou-Gharbia, John Gordon, Premkumar Arumugam, Tangirala Raghuram, Sayan Mitra, Rajashekar Reddy Nimmareddy, Mahesh Yanamandra, Savithiri Shivakumar, Pratima Srivastava, Benjamin E. Blass, Mercy Ramanjulu, Konda Venkataramanaiah
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(13)
The synthesis of steroid hormones is critical to human physiology and improper regulation of either the synthesis of these key molecules or activation of the associated receptors can lead to disease states. This has led to intense interest in develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354c82121aa58b627ad47925cbf73334
https://pubmed.ncbi.nlm.nih.gov/29803730
https://pubmed.ncbi.nlm.nih.gov/29803730
Autor:
Wayne E. Childers, Mahesh Yanamandra, Boruwa Joshodeep, Premkumar Arumugam, Pravin Iyer, Shalini Paliwal, John W. Ellingboe, Tangirala Raghuram, Savithiri Shivakumar, Mercy Ramanjulu, Benjamin E. Blass, John Gordon, Konda Venkataramanaiah, Rajashekar Reddy Nimmareddy, Sayan Mitra, Jamallamudi Rajasekhar, Magid Abou-Gharbia, Pratima Srivastava, George Morton
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(23)
Metabolic Syndrome, also referred to as 'Syndrome X' or 'Insulin Resistance Syndrome,' remains a major, unmet medical need despite over 30years of intense effort. Recent research suggests that there may be a causal link between this condition and abn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666d32618bba9d60a5758e048c0f3e4d
https://pubmed.ncbi.nlm.nih.gov/27789139
https://pubmed.ncbi.nlm.nih.gov/27789139
Autor:
Stevan W. Djuric, Rose Mathew, Richard Labaudiniere, Paul Joseph Cox, John E. Souness, Ken M. Page, Joanne Uhl, Bruce Miller, Christopher Hulme, Fu Chih Huang, Mercy Ramanjulu, Kevin J. Moriarty, Jeffrey Travis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3053-3058
This communication describes the synthesis and in vitro and in vivo evaluation of a novel potent series of phosphodiesterase type (IV) (PDE4) inhibitors. Several of the compounds presented possess low nanomolar IC50's for PDE4 inhibition and excellen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfa39770c13424996daf7b71d8543a0
https://doi.org/10.1016/s0960-894x(98)00572-1
https://doi.org/10.1016/s0960-894x(98)00572-1
Autor:
Mercy Ramanjulu, Ann Y. Liauw, Thomas P. Maduskuie, Jere E. Meredith, Jeffrey N. Higaki, Robert Zaczek, Barbara Cordell, Arthur H. Roach, Dietmar A. Seiffert, David Robertson, Padmaja Kasireddy-Polam, Lorin A. Thompson, Marcie A. Glicksman, Stephen E. Mercer, Andrew P. Combs, Richard E. Olson, Rui-Qin Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
The synthesis, evaluation, and structure-activity relationships of a series of succinoyl lactam inhibitors of the Alzheimer's disease gamma-secretase are described. Beginning with a screening hit with broad proteinase activity, optimization provided
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15589f134d4cb016d3cf88127c79f08f
https://pubmed.ncbi.nlm.nih.gov/16473009
https://pubmed.ncbi.nlm.nih.gov/16473009