Výsledky vyhledávání - "Merci N. Best"

Extracellular Tau Oligomers Damage the Axon Initial Segment

Autor: Merci N. Best, Yunu Lim, Nina N. Ferenc, Nayoung Kim, Lia Min, Dora Bigler Wang, Kamyar Sharifi, Anna E. Wasserman, Sloane A. McTavish, Karsten H. Siller, Marieke K. Jones, Paul M. Jenkins, James W. Mandell, George S. Bloom

Publikováno v: Journal of Alzheimer's Disease. :1-17

Background: In Alzheimer’s disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating polarity and functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from ax

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57c51a31c705c4eed0b2c27031690427
https://doi.org/10.3233/jad-221284

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Bone Morphogenetic Protein (BMP) signaling regulates germline stem cell self-renewal in the newly formed Drosophila testis stem cell niche

Autor: Merci N Best, Ashley Fidler, Marieke K Jones, Matthew Wawersik

Bone morphogenetic proteins (BMPs) are a group of multifunctional cytokines and metabologens highly conserved in the transforming growth factor-β (TGF-β) superfamily. BMPs have an established role in controlling cell fate and tissue morphogenesis i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b97a6feae7d33cf8c9bfd5e94b0b38aa
https://doi.org/10.1101/2022.03.26.485802

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STEAM Programming as a Pathway to Foster Positive Academic Self-Efficacy and Positive Self-Concept

Autor: Merci N Best, Cheryl L. Dickter, Robin Best

Publikováno v: Journal of Research in STEM Education. 5:100-118

Multicultural individuals are underrepresented in the fields of science, technology, engineering, and mathematics (STEM). Therefore, the current study is focused on exploring STEAMtrix, a STEM out-of-school time (OST) education program that incorpora

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25979c802438ccaecaa29041003b75b9
https://doi.org/10.51355/jstem.2019.54

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Intraneuronal Tau Misfolding Induced by Extracellular Amyloid-β Oligomers

Autor: Merci N Best, Ammasi Periasamy, Zdenek Svindrych, George S. Bloom, Horst Wallrabe, Lauren K Rudenko, Karsten H. Siller, Matthew E. Seward

Publikováno v: J Alzheimers Dis

Abnormal folding and aggregation of the microtubule-associated protein, tau, is a hallmark of several neurodegenerative disorders, including Alzheimer's disease (AD). Although normal tau is an intrinsically disordered protein, it does exhibit tertiar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a7d527ca39b4f71917f1cf38278370
https://europepmc.org/articles/PMC7464573/

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