Výsledky vyhledávání - "Mercedes Villarroya"

Chromaffin cells as a model to evaluate mechanisms of cell death and neuroprotective compounds

Autor: Mercedes Villarroya, Manuela G. López, Cristóbal de los Ríos, María F. Cano-Abad

Publikováno v: Pflügers Archiv - European Journal of Physiology. 470:187-198

In this review, we show how chromaffin cells have contributed to evaluate neuroprotective compounds with diverse mechanisms of action. Chromaffin cells are considered paraneurons, as they share many common features with neurons: (i) they synthesize,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd3bd7290812fcf9deca4127aa5cea8
https://doi.org/10.1007/s00424-017-2044-5

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Enzymatic and solid-phase synthesis of new donepezil-based L- and D-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia

Autor: María Isabel Rodríguez-Franco, Mariana P. Arce, Santiago Conde, Concepción Pérez, Mercedes Villarroya, Rafael León, Leticia Monjas, Javier Egea, Carmen Gil, Manuela G. López

Publikováno v: European Journal of Medicinal Chemistry, 130, 60-72. ELSEVIER MASSON, CORPORATION OFFICE
Digital.CSIC. Repositorio Institucional del CSIC
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Supplementary data associated with this article can be found in the online version, at http://dx.doi.org/10.1016/j.ejmech.2017.02. 034. These data include MOL files and InChiKeys of the most important compounds described in this article.
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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6a73f5f93f64a23841effd0f66659a1
http://hdl.handle.net/10261/148915

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PP2A Ligand ITH12246 Protects against Memory Impairment and Focal Cerebral Ischemia in Mice

Autor: Mercedes Villarroya, Laura González-Lafuente, Francisco J. Martínez-Sanz, Martín Estrada, Abdelouahid Samadi, Cristóbal de los Ríos, María Isabel Rodríguez-Franco, José Marco-Contelles, Rocío Lajarín-Cuesta, Alejandro Romero, Silvia Lorrio, Manuela G. López

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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ITH12246 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8] naphthyridine-3-carboxylate) is a 1,8-naphthyridine described to feature an interesting neuroprotective profile in in vitro models of Alzheimer's disease. These effects were proposed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca2e954f75cb49b94b7784eeb4d957e
https://doi.org/10.1021/cn400050p

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Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives

Autor: M. Carmo Carreiras, José Marco-Contelles, Manuela G. López, Alejandro Romero, Cristóbal de los Ríos, María-Luisa Jimeno, Abdelouahid Samadi, Daniel Silva, Eduarda Mendes, Mourad Chioua, Mercedes Villarroya

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The synthesis and pharmacological analyses of a number of pyrazolo[3,4-b]quinoline and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives are reported. We have synthesized the diversely substituted tacrine analogues 1-6, by Friedländer-type react

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bedc248c0793e9a9bd238c5fffaed45a
https://doi.org/10.1016/j.ejmech.2011.05.068

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Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

Autor: José Marco-Contelles, Laura González-Lafuente, Maria Dolores Martin-de-Saavedra, Abdelouahid Samadi, Mourad Chioua, Agatha Bastida, Mercedes Villarroya, Laura del Barrio, Cristóbal de los Ríos, Luis Gandía, Inés Colmena, Carolina Valderas, Manuela G. López, Alejandro Romero

Publikováno v: Bioorganic & Medicinal Chemistry. 19:122-133

The synthesis, biological assessment, and molecular modelling of new tacrine analogues 11–22 is described. Compounds 11–22 have been obtained by Friedlander-type reaction of 2-aminopyridine-3-carbonitriles 1–10 with cyclohexanone or 1-benzyl-4-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5737e5b235a58b5a7587e61d947e3b77
https://doi.org/10.1016/j.bmc.2010.11.040

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Synthesis, Inhibitory Activity of Cholinesterases, and Neuroprotective Profile of Novel 1,8-Naphthyridine Derivatives

Autor: Isabel Iriepa, Antonio G. García, Alejandro Romero, Mercedes Villarroya, José Marco-Contelles, Manuela G. López, Ignacio Moraleda, Rafael León, Abdelouahid Samadi, Enrique Gálvez, Cristóbal de los Ríos, Javier Egea

Publikováno v: Journal of Medicinal Chemistry. 53:5129-5143

1,8-Naphthyridine derivatives related to 17 (ITH4012), a neuroprotective compound reported by our research group, have been synthesized. In general, they have shown better inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6760f2aee0249d0cf6e8101a27f9d0cf
https://doi.org/10.1021/jm901902w

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New tacrine-dihydropyridine hybrids that inhibit acetylcholinesterase, calcium entry, and exhibit neuroprotection properties

Autor: Xavier Barril, Antonio G. García, Oscar Huertas, F. Javier Luque, Mercedes Villarroya, Rafael León, Cristóbal de los Ríos, Manuela G. López, José Marco-Contelles

Publikováno v: Bioorganic & Medicinal Chemistry. 16:7759-7769

In this communication, we describe the synthesis and biological evaluation of tacripyrimedones 1-5, a series of new tacrine-1,4-dihydropyridine hybrids bearing the general structure of 11-amino-12-aryl-3,3-dimethyl-3,4,5,7,8,9,10,12-octahydrodibenzo[

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d2311a67c2cc2830f527b8b2f51c30
https://doi.org/10.1016/j.bmc.2008.07.005

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Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death

Autor: Mercedes Villarroya, Rafael León, José Marco-Contelles, Cristóbal de los Ríos, Antonio G. García, Manuela G. López

Publikováno v: European Journal of Medicinal Chemistry. 43:668-674

The synthesis and pharmacology of 6-amino-1,4-dihydropyridines, such as ethyl 6-amino-4-aryl-5-cyano-1,4-dihydro-2-methyl-3-pyridinecarboxylic acids ( 3 – 16 ) and 2-amino-4-aryl-7,7-dimethyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinenitriles ( 17 –

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72cec7506898fc0dc49d39739cb3fa4
https://doi.org/10.1016/j.ejmech.2007.06.001

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Comparative phytotoxicity assays of the herbicide alloxydim and its main identified photoproduct in cereal and broadleaves crops

Autor: Beatriz Sevilla-Morán, M. Inés Santín-Montanyá, José Luis Alonso-Prados, Pilar Sandín-España, Mercedes Villarroya-Ferruz

Publikováno v: Repositorio de Resultados de Investigación del INIA
INIA: Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA

When herbicides are sprayed in the field, a proportion of the herbicide falls onto leaves and soil surfaces, where it can be exposed to sunlight, generating photoproducts that can be more toxic and/or persistent than the parent substance and affect h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8279f4df5d2ecd1777cd693e2a7bbea
https://hdl.handle.net/20.500.12792/4144

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