Complement factor H contributes to mortality in humans and mice with bacterial meningitis

Autor: E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement fac

Externí odkaz: https://doaj.org/article/709758e90fc34fbda773f3104d709fc5

Detrimental role for CCAAT/enhancer binding protein δ in blood-borne brain infection

Autor: JanWillem Duitman, Mercedes Valls Serón, JooYeon Engelen-Lee, Matthijs C. Brouwer, C. Arnold Spek, Diederik van de Beek

Publikováno v: BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-6 (2016)

Abstract Background The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus (S.) pneumoniae. CCAAT/enhancer binding protein δ is a transcription factor that has recently been hypothesized to play a de

Externí odkaz: https://doaj.org/article/342fc2bc92ef4ebda145aef0a41ce1c2

Microglial Activation After Systemic Stimulation With Lipopolysaccharide and Escherichia coli

Autor: Inge C. M. Hoogland, Dunja Westhoff, Joo-Yeon Engelen-Lee, Jeroen Melief, Mercedes Valls Serón, Judith H. M. P. Houben-Weerts, Inge Huitinga, David J. van Westerloo, Tom van der Poll, Willem A. van Gool, Diederik van de Beek

Publikováno v: Frontiers in Cellular Neuroscience, Vol 12 (2018)

Background: Microglial activation after systemic infection has been suggested to mediate sepsis-associated delirium. A systematic review of animal studies suggested distinct differences between microglial activation after systemic challenge with live

Externí odkaz: https://doaj.org/article/91a8d9dfa4fe468c8723a19ba8fe8c93

Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis

Autor: Mercedes Valls Serón, Arie van der Ende, Diederik van de Beek, Matthijs C. Brouwer, Michael W.T. Tanck, Ben Schmand, Anne T. Kloek

Publikováno v: Acta Neuropathologica Communications
Acta neuropathologica communications, 9(1):4. BioMed Central
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-10 (2021)
Kloek, A T, Seron, M V, Schmand, B, Tanck, M W T, van der Ende, A, Brouwer, M C & van de Beek, D 2021, ' Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis ', Acta neuropathologica communications, vol. 9, no. 1, 4 . https://doi.org/10.1186/s40478-020-01100-7

Background Patients with pneumococcal meningitis are at risk for death and neurological sequelae including cognitive impairment. Functional genetic polymorphisms of macrophage migration inhibitory factor (MIF) alleles have shown to predict mortality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3848f30e50ba7e2e543195e3dc19f5d3
https://pubmed.ncbi.nlm.nih.gov/33407905

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Autor: Anne von Gottberg, Jan H. Veldink, Wouter van Rheenen, Nynke Y. Rots, Lars Ängquist, Anne L. Wyllie, Lisette C. P. G. M. de Groot, Hester J. Bootsma, Ellen A. Nohr, Lene Fogt Lundbo, Rebecca A. Gladstone, Susan A. Nzenze, Thomas Benfield, Aeilko H. Zwinderman, Julian C. Knight, Jeffrey N. Weiser, Krzysztof Trzciński, Nicholas J. Croucher, Shabir Madhi, Mignon du Plessis, Thorkild I. A. Sørensen, Tara C. Mills, Bart Ferwerda, Elisabeth A. M. Sanders, Nicole E. Wheeler, Diederik van de Beek, Philip H. C. Kremer, Jeffrey C. Barrett, Alexander J. Mentzer, Stephen D. Bentley, Matthijs C. Brouwer, Mercedes Valls Serón, Nathalie van der Velde, Alienke J. Wijmega-Monsuur, Leonard H. van den Berg, Arie van der Ende, Zitta Barrella Harboe, Natasja M. van Schoor, Julian Parkhill, John A. Lees

Publikováno v: Nature Communications, 10:2176. Nature Publishing Group
Nature Communications 10 (2019) 1
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Seron, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzcinski, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Angquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1):2176. Nature Publishing Group UK
Nature Communications
Nature communications, 10(1):2176. Nature Publishing Group
Lees, J A, Ferwerda, B, Kremer, P H C, Wheeler, N E, Serón, M V, Croucher, N J, Gladstone, R A, Bootsma, H J, Rots, N Y, Wijmega-Monsuur, A J, Sanders, E A M, Trzciński, K, Wyllie, A L, Zwinderman, A H, van den Berg, L H, van Rheenen, W, Veldink, J H, Harboe, Z B, Lundbo, L F, de Groot, L C P G M, van Schoor, N M, van der Velde, N, Ängquist, L H, Sørensen, T I A, Nohr, E A, Mentzer, A J, Mills, T C, Knight, J C, du Plessis, M, Nzenze, S, Weiser, J N, Parkhill, J, Madhi, S, Benfield, T, von Gottberg, A, van der Ende, A, Brouwer, M C, Barrett, J C, Bentley, S D & van de Beek, D 2019, ' Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis ', Nature Communications, vol. 10, no. 1, 2176 . https://doi.org/10.1038/s41467-019-09976-3
Nature Communications, 10(1)

Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee6d7584fa83d9ebe796545bc02603c
https://www.repository.cam.ac.uk/handle/1810/294917