Monoaminergic and histaminergic strategies and treatments in brain diseases

Autor: Giuseppe Di Giovanni, Dubravka Svob Strac, Montse Sole, Mercedes Unzeta, Keith Francis Tipton, Dorotea Mück-Šeler, Irène Bolea, Laura Della Corte, Matea Nikolac Perkovic, Nela Pivac, Ilse Julia Smolders, Anna Stasiak, Wieslawa Agnieszka Fogel, Philippe De Deurwaerdère

Publikováno v: Frontiers in Neuroscience, Vol 10 (2016)

The monoaminergic systems are the target of several drugs for the treatment of mood, motor and cognitive disorders as well as neurological conditions. In most cases, advances have occurred through serendipity, except for Parkinson’s disease where t

Externí odkaz: https://doaj.org/article/ca03d10c8f154678a9908f3f996bd1dd

CYP-Dependent Metabolism of PF9601N, A New Monoamine Oxidase-B Inhibitor, by C57BL / 6 Mouse and Human Liver Microsomes

Autor: Stefania Dragoni, Giada Materozzi, Federica Pessina, Maria Frosini, José Luis Marco, Mercedes Unzeta, Giampietro Sgaragli, Massimo Valoti

Publikováno v: Journal of Pharmacy & Pharmaceutical Sciences, Vol 10, Iss 4 (2007)

Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine. Subsequently, this has promote

Externí odkaz: https://doaj.org/article/1d8dd3524db449249fb1aa6b3db3ce96

Inhibition of semicarbazide-sensitive amine oxidase reduces atherosclerosis in apolipoprotein E-deficient mice

Autor: Mercedes Unzeta, Tse-Ya Yu, Lee-Ming Chuang, Mao-Shin Lin, Hsien-Li Kao, Christopher J. Weston, Montse Solé, Yu I. Li, Shu-Huei Wang, Chi-Sheng Hung, Feng-Chiao Tsai, Yuh-Lien Chen, Hung-Yuan Li

Publikováno v: Translational Research. 197:12-31

Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0c29ee3d417d4d754beb85f3b8ed48
https://doi.org/10.1016/j.trsl.2018.03.001

Synthesis, biological evaluation, and molecular modeling of nitrile-containing compounds: Exploring multiple activities as anti-Alzheimer agents

Autor: Rona R. Ramsay, José Marco-Contelles, Eleanor J. Summers, Ana M. F. Oliveira-Campos, Ana Neca, M. Carmo Carreiras, M. Luísa Mateus, Paula Agostinho, Irene Bolea, Daniel Silva, Mercedes Unzeta, M. Luisa Jimeno, Eduarda Mendes, Telma Reis, Magdalena Majekova, Ana C. Jacinto

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Based on the monoamine oxidase (MAO) inhibition properties of aminoheterocycles with a carbonitrile group we have carried out a systematic exploration to discover new classes of carbonitriles endowed with dual MAO and AChE inhibitory activities, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdcde5cd566b32f17276c69d9c0fd09
http://hdl.handle.net/10261/194870

Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD

Autor: Mercedes Unzeta, Núria Casals, Dolores Siedlecki-Wullich, Alfredo J. Miñano-Molina, Rut Fadó, José Rodríguez-Alvarez, Montse Solé, Judit Català-Solsona, Cristina Fábregas, Wenwen Cheng, Carlos A. Saura

Publikováno v: Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
eNeuro
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

Altres ajuts: This work was partially supported by grants from the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas Grant CB06/05/0042, the Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4295cbf35abb33e3825624f59d89d2e9
https://doi.org/10.1523/eneuro.0218-19.2020