Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mercedes Tomé"'
Autor:
Simon Pernot, Mercedes Tomé, Isabel Galeano-Otero, Serge Evrard, Iker Badiola, Frederic Delom, Delphine Fessart, Tarik Smani, Geraldine Siegfried, Bruno O. Villoutreix, Abdel-Majid Khatib
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
The overexpression of the immunoinhibitory receptor programmed death-1 (PD1) on T-cells is involved in immune evasion in cancer. The use of anti-PD-1/PDL-1 strategy has deeply changed the therapies of cancers and patient survival. However, their effi
Externí odkaz:
https://doaj.org/article/90571bd8e03445089bd4c69afb1017e6
Autor:
Iván Durán-Díaz, Auxiliadora Sarmiento, Irene Fondón, Clément Bodineau, Mercedes Tomé, Raúl V. Durán
Publikováno v:
Entropy, Vol 26, Iss 2, p 165 (2024)
Immunohistochemistry is a powerful technique that is widely used in biomedical research and clinics; it allows one to determine the expression levels of some proteins of interest in tissue samples using color intensity due to the expression of biomar
Externí odkaz:
https://doaj.org/article/4b25ba6ef71a488084b8f0f90defa426
Autor:
Clément Bodineau, Mercedes Tomé, Sarah Courtois, Ana S. H. Costa, Marco Sciacovelli, Benoit Rousseau, Elodie Richard, Pierre Vacher, Carlos Parejo-Pérez, Emilie Bessede, Christine Varon, Pierre Soubeyran, Christian Frezza, Piedad del Socorro Murdoch, Victor H. Villar, Raúl V. Durán
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The metabolism of amino acids and the cellular energy sensor AMPK are both connected to mTORC1, but the pathway details have not been well defined. Here, the authors show that glutamine metabolism and mTORC1 have two regulatory connections with relev
Externí odkaz:
https://doaj.org/article/4b6d4a30886f478a8c8fe16da840f895
Autor:
Raffaele Nicastro, Hélène Gaillard, Laura Zarzuela, Marie-Pierre Péli-Gulli, Elisabet Fernández-García, Mercedes Tomé, Néstor García-Rodríguez, Raúl V Durán, Claudio De Virgilio, Ralf Erik Wellinger
Publikováno v:
eLife, Vol 11 (2022)
The essential biometal manganese (Mn) serves as a cofactor for several enzymes that are crucial for the prevention of human diseases. Whether intracellular Mn levels may be sensed and modulate intracellular signaling events has so far remained largel
Externí odkaz:
https://doaj.org/article/1ff9d19bbeca408a883f1177dc21884e
Autor:
Noemí Cabré, Fedra Luciano-Mateo, Douglas J. Chapski, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Helena Castañé, Elisabet Rodríguez-Tomàs, Marta París, Fàtima Sabench, Daniel Del Castillo, Josep M. del Bas, Mercedes Tomé, Clément Bodineau, Alejandro Sola-García, José López-Miranda, Alejandro Martín-Montalvo, Raúl V. Durán, Thomas M. Vondriska, Manuel Rosa-Garrido, Jordi Camps, Javier A. Menéndez, Jorge Joven
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7830 (2022)
The surgically induced remission of liver disease represents a model to investigate the signalling processes that trigger the development of nonalcoholic steatohepatitis with the aim of identifying novel therapeutic targets. We recruited patients wit
Externí odkaz:
https://doaj.org/article/98b8b7e9308e419daf0a83b1afd3442c
Autor:
Auxiliadora Sarmiento, Iván Durán-Díaz, Irene Fondón, Mercedes Tomé, Clément Bodineau, Raúl V. Durán
Publikováno v:
Entropy, Vol 24, Iss 4, p 546 (2022)
In many research laboratories, it is essential to determine the relative expression levels of some proteins of interest in tissue samples. The semi-quantitative scoring of a set of images consists of establishing a scale of scores ranging from zero o
Externí odkaz:
https://doaj.org/article/17f862d2a5384a828d0c8f46311730f2
Publikováno v:
Stem Cell Research, Vol 35, Iss , Pp - (2019)
Notch signalling regulates neural stem cell (NSC) proliferation, differentiation and survival for the correct development and functioning of the central nervous system. Overactive Notch2 signalling has been associated with poor prognosis of aggressiv
Externí odkaz:
https://doaj.org/article/ac5cef1c70944dfc85209ba33487ca15
Autor:
Elena Gómez-Marín, Melanija Posavec-Marjanović, Laura Zarzuela, Laura Basurto-Cayuela, José A Guerrero-Martínez, Gonzalo Arribas, Rosario Yerbes, María Ceballos-Chávez, Manuel Rodríguez-Paredes, Mercedes Tomé, Raúl V Durán, Marcus Buschbeck, José C Reyes
Publikováno v:
Nucleic Acids Research. 50:9838-9857
High mobility group (HMG) proteins are chromatin regulators with essential functions in development, cell differentiation and cell proliferation. The protein HMG20A is predicted by the AlphaFold2 software to contain three distinct structural elements
Autor:
Pascal Collin, Raúl V. Durán, Bogdan I. Iorga, Pierre Soubeyran, Abdel-Majid Khatib, Serge Evrard, Silvia Terés, Kahina Abbas, Fabienne Peyrot, Yves-Michel Frapart, Georgiana Surpateanu, Bernard Delpech, Odile Thoison, Jérôme Bignon, Maria Concepcion Garcia-Alvarez, Joanna Wdzieczak-Bakala, Lætitia Minder, Carmelo Di Primo, Clément Bodineau, Mercedes Tomé, Maxim Egorov, Marie-Julie Nokin, Tra-Ly Nguyen
The file contains supplementary results showing that ICSN3250 specifically inhibited mTORC1 pathway.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256c97c0889846af4088728142a53d42
https://doi.org/10.1158/0008-5472.22419362.v1
https://doi.org/10.1158/0008-5472.22419362.v1
Autor:
Pascal Collin, Raúl V. Durán, Bogdan I. Iorga, Pierre Soubeyran, Abdel-Majid Khatib, Serge Evrard, Silvia Terés, Kahina Abbas, Fabienne Peyrot, Yves-Michel Frapart, Georgiana Surpateanu, Bernard Delpech, Odile Thoison, Jérôme Bignon, Maria Concepcion Garcia-Alvarez, Joanna Wdzieczak-Bakala, Lætitia Minder, Carmelo Di Primo, Clément Bodineau, Mercedes Tomé, Maxim Egorov, Marie-Julie Nokin, Tra-Ly Nguyen
The mTOR is a central regulator of cell growth and is highly activated in cancer cells to allow rapid tumor growth. The use of mTOR inhibitors as anticancer therapy has been approved for some types of tumors, albeit with modest results. We recently r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e468b6ae475074a34cb8808fe4ce17db
https://doi.org/10.1158/0008-5472.c.6510359.v1
https://doi.org/10.1158/0008-5472.c.6510359.v1