Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Mercedes Rincon"'
Autor:
Meng-Han Wu, Felipe Valenca-Pereira, Francesca Cendali, Emily L. Giddings, Catherine Pham-Danis, Michael C. Yarnell, Amanda J. Novak, Tonya M. Brunetti, Scott B. Thompson, Jorge Henao-Mejia, Richard A. Flavell, Angelo D’Alessandro, M. Eric Kohler, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Mitochondrial respiration is essential for the survival and function of T cells used in adoptive cellular therapies. However, strategies that specifically enhance mitochondrial respiration to promote T cell function remain limited. Here, we
Externí odkaz:
https://doaj.org/article/d0884f5a1b81480bad4290e7a5d667fa
Autor:
Shanti Choudhary, Michelle LaCasse, Ratan Kumar Choudhary, Mercedes Rincon, Donald C. Beitz, Eric D. Testroet
Publikováno v:
Animals, Vol 13, Iss 6, p 1101 (2023)
Mitochondrial complex I inhibitor (iC1) is a methylation-controlled J protein (MCJ) that decreases cellular respiration by inhibiting oxidative phosphorylation. Recent rodent studies showed that loss or inhibition of iC1 was associated with preventin
Externí odkaz:
https://doaj.org/article/10b37d2695ca485099a776d9ff261af3
Autor:
Emily L. Giddings, Devin P. Champagne, Meng-Han Wu, Joshua M. Laffin, Tina M. Thornton, Felipe Valenca-Pereira, Rachel Culp-Hill, Karen A. Fortner, Natalia Romero, James East, Phoebe Cao, Hugo Arias-Pulido, Karatatiwant S. Sidhu, Brian Silverstrim, Yoonseok Kam, Shana Kelley, Mark Pereira, Susan E. Bates, Janice Y. Bunn, Steven N. Fiering, Dwight E. Matthews, Robert W. Robey, Domink Stich, Angelo D’Alessandro, Mercedes Rincon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Drug efflux through ABC transporters is a common mechanism leading to chemoresistance in cancer. Here, the authors show that mitochondrial respiration provides ATP to allow ABC transporters activity so mitochondrial respiration inhibition overcomes c
Externí odkaz:
https://doaj.org/article/96cc5e262fc1481b86eceff834f1a9ce
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 337 (2022)
The inhibition of Glycogen Synthase Kinase 3 β (GSK3β) by Ser9 phosphorylation affects many physiological processes, including the immune response. However, the consequences of GSK3β inhibition by alternative Ser389 phosphorylation remain poorly c
Externí odkaz:
https://doaj.org/article/aa766c72066b40d18d6653903f655204
Autor:
Elizabeth Ann Bonney, Kendall Krebs, Jihye Kim, Kirtika Prakash, Blake L. Torrance, Laura Haynes, Mercedes Rincon
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Respiratory diseases adversely affect infants and are the focus of efforts to develop vaccinations and other modalities to prevent disease. The infant immune system differs from that of older children and adults in many ways that are as yet ill under
Externí odkaz:
https://doaj.org/article/9f064a6e270a4641a765e9e64500849a
Publikováno v:
International Journal of Biological Sciences, Vol 8, Iss 9, Pp 1281-1290 (2012)
The incidence and severity of chronic lung diseases is growing and affects between 100 and 150 million people worldwide and is associated with a significant rate of mortality. Unfortunately, the initial cause that triggers most chronic lung diseases
Externí odkaz:
https://doaj.org/article/a5f7ecb5d2b24894a6811c7381254547
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1656 (2018)
Stat3 as a transcription factor regulating gene expression in lymphocytes during the immune response is well known. However, since the pioneering studies discovering the presence of Stat3 in mitochondria and its role in regulating mitochondrial metab
Externí odkaz:
https://doaj.org/article/074d386e5330472ca658533a473f97a9
Autor:
Mercedes Rincon
Publikováno v:
International Journal of Biological Sciences, Vol 8, Iss 9, Pp 1225-1226 (2012)
Externí odkaz:
https://doaj.org/article/bfe74d714c0b4ef79e388584be9c647e
Autor:
Ian T. Stancil, Jacob E. Michalski, Corinne E. Hennessy, Kristina L. Hatakka, Ivana V. Yang, Jonathan S. Kurche, Mercedes Rincon, David A. Schwartz
Publikováno v:
Sci Transl Med
Chronic disease results from the failure of tissues to maintain homeostasis. In the lung, coordinated repair of the epithelium is essential for preserving homeostasis. In animal models and human lung disease, airway epithelial cells mobilize in respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2da2f6e5d8daa8074812a2a63d7ba836
https://europepmc.org/articles/PMC9981332/
https://europepmc.org/articles/PMC9981332/
Publikováno v:
Cancer Research. 83:5131-5131
Breast cancer is the most common form of cancer and the second cancer-causing death in females. Although remission rates are high if detected early, survival rates drop substantially when breast cancer becomes metastatic. The most common sites of met