Výsledky vyhledávání - "Mercedes Pérez-Hernández"

Akademický článek

Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Autor: Ana Peñalver, José A. Campos-Sandoval, Eduardo Blanco, Carolina Cardona, Laura Castilla, Mercedes Martín-Rufián, Guillermo Estivill-Torrús, Raquel Sánchez-Varo, Francisco J. Alonso, Mercedes Pérez-Hernández, María I. Colado, Antonia Gutiérrez, Fernando Rodríguez de Fonseca, Javier Márquez

Publikováno v: Frontiers in Molecular Neuroscience, Vol 10 (2017)

Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor and glutamatergic transmiss

Externí odkaz: https://doaj.org/article/ba71ec299ea24689ae9bf5ff3af5f342

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Changes in brain kynurenine levels via gut microbiota and gut‐barrier disruption induced by chronic ethanol exposure in mice

Autor: Luis Alou Cervera, María Isabel Colado, Esther O'Shea, Pablo Giménez-Gómez, David Martín-Hernández, María Luisa Gómez-Lus Centelles, María Dolores Gutiérrez-López, Mercedes Pérez-Hernández, Javier R. Caso

Publikováno v: FASEB J

Inflammatory processes have been shown to modify tryptophan (Trp) metabolism. Gut microbiota appears to play a significant role in the induction of peripheral and central inflammation. Ethanol (EtOH) exposure alters gut permeability, but its effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da98021475aad6b8968a77e388a89f5b
https://doi.org/10.1096/fj.201900491rr

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Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens

Autor: Pablo Giménez-Gómez, Esther O'Shea, María Isabel Colado, Rebeca Vidal, Mercedes Pérez-Hernández, María Dolores Gutiérrez-López, Cristina Abuin-Martínez

Publikováno v: Neuropharmacology. 135:581-591

Recent research suggests that ethanol (EtOH) consumption behaviour can be regulated by modifying the kynurenine (KYN) pathway, although the mechanisms involved have not yet been well elucidated. To further explore the implication of the kynurenine pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9a645667336f6de3150ba82dd22110
https://doi.org/10.1016/j.neuropharm.2018.04.016

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Addiction and the kynurenine pathway: A new dancing couple?

Autor: María Isabel Colado, Cristina Abuin-Martínez, Mercedes Pérez-Hernández, Esther O'Shea, Pablo Giménez-Gómez, Leticia Gil de Biedma-Elduayen, Nuria Morales-Puerto, María Dolores Gutiérrez-López, Rebeca Vidal

Publikováno v: Pharmacology & Therapeutics. 223:107807

Drug use poses a serious threat to health systems throughout the world and the number of consumers rises relentlessly every year. The kynurenine pathway, main pathway of tryptophan degradation, has drawn interest in this field due to its relationship

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef0988d669184b9f66c96b2262a880b9
https://doi.org/10.1016/j.pharmthera.2021.107807

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3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) produces edema due to BBB disruption induced by MMP-9 activation in rat hippocampus

Autor: Ana Rubio-Araiz, María Dolores Gutiérrez-López, María Isabel Colado, Mercedes Pérez-Hernández, Esther O'Shea, María Encarnación Fernández-Valle, Rebeca Vidal

Publikováno v: Neuropharmacology. 118:157-166

The recreational drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier (BBB) integrity in rats through an early P2X7 receptor-mediated event which induces MMP-9 activity. Increased BBB permeability often causes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c0309ddf2e634c422b01d901f89d91
https://doi.org/10.1016/j.neuropharm.2017.03.019

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Increased kynurenine concentration attenuates serotonergic neurotoxicity induced by 3,4-methylenedioxymethamphetamine (MDMA) in rats through activation of aryl hydrocarbon receptor

Autor: Cristina Abuin-Martínez, María Dolores Gutiérrez-López, María Isabel Colado, N. Morales-Puerto, Rebeca Vidal, Esther O'Shea, Pablo Giménez-Gómez, Mercedes Pérez-Hernández

Publikováno v: Neuropharmacology. 187:108490

3,4-Methylenedioxymethamphetamine (MDMA) is an amphetamine derivative that has been shown to produce serotonergic damage in the brains of primates, including humans, and of rats. Tryptophan, the precursor of serotonin, is primarily degraded through t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c9bdd2aa4d6f5a33541d79f101afe12
https://doi.org/10.1016/j.neuropharm.2021.108490

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Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model

Autor: María Auxiliadora Aracil-Fernández, Mercedes Pérez-Hernández, María Isabel Colado, María Dolores Gutiérrez-López, Jorge Manzanares, Mª Salud García-Gutiérrez, Consuelo Guerri, Francesca Porcu, Esther O'Shea, Ana Rubio-Araiz

Publikováno v: Addiction Biology. 22:1103-1116

Inflammatory cytokines and reactive oxygen species are reported to be involved in blood-brain barrier (BBB) disruption. Because there is evidence that ethanol (EtOH) induces release of free radicals, cytokines and inflammatory mediators we examined B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73d3a86545b6d19df9f72a999abb917c
https://doi.org/10.1111/adb.12376

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Glutaminase and MMP-9 Downregulation in Cortex and Hippocampus of LPA1 Receptor Null Mice Correlate with Altered Dendritic Spine Plasticity

Autor: Mercedes Martín-Rufián, Fernando Rodríguez de Fonseca, José A. Campos-Sandoval, Carolina Cardona, Ana Peñalver, Mercedes Pérez-Hernández, Francisco J. Alonso, Guillermo Estivill-Torrús, Antonia Gutierrez, Javier Márquez, Raquel Sanchez-Varo, María Isabel Colado, Eduardo Blanco, Laura Castilla

Publikováno v: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Repositorio Abierto de la UdL
Universitad de Lleida
Recercat. Dipósit de la Recerca de Catalunya
instname
Frontiers in Molecular Neuroscience, Vol 10 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30df4433a27178d3b34800ed2b8fba7f
https://doi.org/10.3389/fnmol.2017.00278

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3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) disrupts blood-brain barrier integrity through a mechanism involving P2X7 receptors

Autor: Mercedes Pérez-Hernández, Francesca Porcu, Erika Borcel, Ana Rubio-Araiz, Esther O'Shea, María Dolores Gutiérrez-López, Andres A. Urrutia, María Isabel Colado

Publikováno v: The International Journal of Neuropsychopharmacology. 17:1243-1255

The recreational drug 3,4-methylenedioxymethamphetamine (MDMA; 'ecstasy') produces a neuro-inflammatory response in rats characterized by an increase in microglial activation and IL-1β levels. The integrity of the blood-brain barrier (BBB) is import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be3b64399154c7c97d2adadbc573caa
https://doi.org/10.1017/s1461145714000145

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