Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Mercedes Lachén"'
Autor:
Mercedes Lachén-Montes, Paz Cartas-Cejudo, Adriana Cortés, Elena Anaya-Cubero, Erika Peral, Karina Ausín, Ramón Díaz-Peña, Joaquín Fernández-Irigoyen, Enrique Santamaría
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 394 (2024)
Alzheimer’s disease (AD) is a neurodegenerative olfactory disorder affecting millions of people worldwide. Alterations in the hexosamine- or glucose-related pathways have been described through AD progression. Specifically, an alteration in glucosa
Externí odkaz:
https://doaj.org/article/6e5775ae53e0466c91ac6350056218d1
Autor:
Paz Cartas-Cejudo, Mercedes Lachén-Montes, Isidro Ferrer, Joaquín Fernández-Irigoyen, Enrique Santamaría
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-20 (2023)
Highlights Quantitative proteomics is a useful approach to biochemically characterize the pathological neurodegeneration that occurs at the level of olfactory areas. Alteration in the olfactory tract proteostasis is more severe in AD than in PD. Prot
Externí odkaz:
https://doaj.org/article/51a1490cd1804b4fa047cd854eafeefd
Autor:
Mercedes Lachén-Montes, Naroa Mendizuri, Karina Ausín, Miriam Echaide, Ester Blanco, Luisa Chocarro, María de Toro, David Escors, Joaquín Fernández-Irigoyen, Grazyna Kochan, Enrique Santamaría
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over the SARS-CoV-2 proteome at olf
Externí odkaz:
https://doaj.org/article/27fdd8bdba5c49dea85533b66498d642
Autor:
Fabíola Zambom-Ferraresi, Fabricio Zambom-Ferraresi, Joaquín Fernández-Irigoyen, Mercedes Lachén-Montes, Paz Cartas-Cejudo, Juan José Lasarte, Noelia Casares, Secundino Fernández, Bernardo Abel Cedeño-Veloz, Enrique Maraví-Aznar, Maria Itziar Uzcanga-Lacabe, Arkaitz Galbete, Enrique Santamaría, Nicolás Martínez-Velilla
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
The aim of this article is to present the research protocol for a prospective cohort study that will assess the olfactory function and the effect of an intervention based on olfactory training in healthy very old adults (≥75 years old). A convenien
Externí odkaz:
https://doaj.org/article/47bc288459bc4762bfe6d651735d778c
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Like other RNA viruses, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in host cells, continuously modulating the molecular environment. It encodes 28 multifunctional proteins that induce an imbalance in the metabolic and pro
Externí odkaz:
https://doaj.org/article/ea8ed10fc29143169387032e3b23e9bb
Autor:
Mercedes Lachén-Montes, Andrea González-Morales, María Victoria Zelaya, Estela Pérez-Valderrama, Karina Ausín, Isidro Ferrer, Joaquín Fernández-Irigoyen, Enrique Santamaría
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Abstract Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysi
Externí odkaz:
https://doaj.org/article/29858517ff7646809eb90c4f31b52069
Autor:
Paz Cartas-Cejudo, Adriana Cortés, Mercedes Lachén-Montes, Elena Anaya-Cubero, Joaquín Fernández-Irigoyen, Enrique Santamaría
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 7, Pp 1997-1998 (2025)
Externí odkaz:
https://doaj.org/article/b790212e1aa449d7b064f99b18ae011b
Autor:
Deeptarup Biswas, Neha Kumari, Mercedes Lachén-Montes, Sampurna Dutta, Ishita Agrawal, Debabrata Samanta, Sanjyot Vinayak Shenoy, Ankit Halder, Joaquín Fernández-Irigoyen, Advait Rahul Padhye, Enrique Santamaría, Sanjeeva Srivastava
Publikováno v:
Journal of Proteome Research. 22:1043-1055
Post-translational modifications (PTMs) are one of the compulsive and predominant biological processes that regulate the diverse molecular mechanism, modulate the onset of disease, and are the reason behind the functional diversity of proteins. Despi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5c6684412967a14e54772b0c152d6d
https://doi.org/10.1021/acs.jproteome.2c00244
https://doi.org/10.1021/acs.jproteome.2c00244
Autor:
Pol Andrés-Benito, África Flores, Sara Busquet-Areny, Margarita Carmona, Karina Ausín, Paz Cartas-Cejudo, Mercedes Lachén-Montes, José Antonio Del Rio, Joaquín Fernández-Irigoyen, Enrique Santamaría, Isidro Ferrer
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 7; Pages: 6559
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with WT mice, tau-KO mice display
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d859df2b516c1a1d0ae80e4595387aa
Autor:
Paz Cartas-Cejudo, Mercedes Lachén-Montes, Isidro Ferrer, Joaquín Fernández-Irigoyen, Enrique Santamaría
Background: Smell impairment is one of the earliest features in Alzheimer’s (AD) and Parkinson’s diseases (PD). Due to sex differences exist in terms of smell and olfactory structures as well as in the prevalence and manifestation of both neurolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe13b88b2aef4a9494968ff136a9ee2d
https://doi.org/10.21203/rs.3.rs-2373739/v1
https://doi.org/10.21203/rs.3.rs-2373739/v1
