Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Mercedes Griera-Merino"'
1
Tripeptides as Integrin-Linked Kinase Modulating Agents Based on a Protein–Protein Interaction with α-Parvin
Autor: Manuel Rodríguez-Puyol, Javier García-Marín, Sergio de Frutos, Ramón Alajarín, Juan J. Vaquero, Mercedes Griera-Merino, Diego Rodríguez-Puyol, Alejandra Matamoros-Recio
Publikováno v: e_Buah Biblioteca Digital Universidad de Alcalá
instname
ACS Medicinal Chemistry Letters
Integrin-linked kinase (ILK) has emerged as a controversial pseudokinase protein that plays a crucial role in the signaling process initiated by integrin-mediated signaling. However, ILK also exhibits a scaffolding protein function inside cells, cont
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a480163747e797ecdeb2ada9caae324
https://doi.org/10.1021/acsmedchemlett.1c00183
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2
MO610: A Graphene-Based Bioactive Compound Reduces Adipogenesis and Increases Lipolysis Via Integrin-Beta1 Interaction: A New Therapeutical Approach Against Obesity
Autor: Mercedes Griera-Merino, María del Prado Lavin-Lopez, Sofía Campillo de Blas, Elena Gutiérrez-Calabrés, Laura Calleros, Martin Martinez, Jose Martinez, Manuel Rodriguez-Puyol, Diego Rodríguez-Puyol, Sergio De Frutos García
Publikováno v: Nephrology Dialysis Transplantation. 37
BACKGROUND AND AIMS Type 2 diabetes and obesity are metabolic disorders related to kidney risk and associated with white adipose tissue (WAT) hypertrophy, which is based in a pro-adipogenic transdifferentiation of the adipocytes and their precursors
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26915109f17d232e4a7e90e195983538
https://doi.org/10.1093/ndt/gfac076.003
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3
P0980IMPLICATIONS OF ADIPOSE EARLY DOWNREGULATION OF INTEGRIN-LINKED KINASE (ILK) IN THE DEVELOPMENT OF METABOLIC SYNDROME IN MICE
Autor: Laura Calleros, Diego García-Ayuso, Mercedes Griera-Merino, Manuel Rodríguez-Puyol, Sergio De Frutos García, Diego Rodríguez-Puyol, Sofía Campillo de Blas, Lourdes Bohorquez Magro, Marta Barrionuevo-González, Elena Gutiérrez-Calabrés
Publikováno v: Nephrology Dialysis Transplantation. 35
Background and Aims Insulin resistance (IR)-related metabolic disorders, such as diabetes type 2 and obesity, are linked to renal and cardiovascular risk. Unfortunately, they lack a better prognosis before their full establishment. An important mecha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::540b2ebec08845a3c588dad0a5755924
https://doi.org/10.1093/ndt/gfaa142.p0980
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4
P0675LEUCOCYTE PODOSOME FORMATION AND ADHESION TO ENDOTHELIUM IS MEDIATED BY INTEGRIN LINKED KINASE IN CHRONIC KIDNEY DISEASE (CKD)
Autor: Elena Gutiérrez-Calabrés, Sergio De Frutos García, Mercedes Griera-Merino, David Vaillo, Diego García Ayuso, Laura Calleros, Sofía Campillo de Blas, M. Rodriguez-Puyol, Lourdes Bohorquez Magro, Diego Rodríguez-Puyol
Publikováno v: Nephrology Dialysis Transplantation. 35
Background and Aims Patients with CKD have a higher risk of developing cardiovascular diseases. Protein-bound uremic toxins, such as p-cresol (pc) and indoxyl-sulfate (IS), are retention solutes, poorly removed during hemodialysis. They lead to endot
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8be63bb1a4e3f31260ada77d1ada5bdb
https://doi.org/10.1093/ndt/gfaa142.p0675
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5
P0020THE NEPHRO-PROTECTIVE ROUTE OF CGMP DOES NOT COMPENSATE NPRHOGENIC DIABETES INSIPIDUS, BOTH CONDITIONS MEDIATED BY RENAL INTEGRIN LINKED KINASE (ILK)
Autor: Laura Calleros, Mercedes Griera-Merino, Lourdes Bohorquez Magro, Diego Rodríguez-Puyol, Diego García-Ayuso, Marta Barrionuevo-González, Sergio De Frutos García, Elena Gutiérrez-Calabrés, Sofía Campillo de Blas, M. Rodriguez-Puyol
Publikováno v: Nephrology Dialysis Transplantation. 35
Background and Aims Renal ILK transgenic deletion on mice (cKD-ILK) address basal polyuria compatible with nephrogenic diabetes insipidus (NDI), due to disrupted tubular water channel aquaporin 2 (AQP2) AQP2 expression and vesicular trafficking to th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::161d0d63581973142db3fbb9c7817ffb
https://doi.org/10.1093/ndt/gfaa142.p0020
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6
P0992PHARMACOLOGICAL UPREGULATION OF INTEGRIN-LINKED KINASE (ILK) REDUCES VISCERAL ADIPOSITY IN A METABOLIC SYNDROME MICE MODEL
Autor: Sofía Campillo de Blas, Mercedes Griera-Merino, Lourdes Bohorquez Magro, Manuel Rodríguez-Puyol, Laura Calleros, David Vaillo, Diego Rodríguez-Puyol, Diego García-Ayuso, Elena Gutiérrez-Calabrés, Sergio De Frutos García
Publikováno v: Nephrology Dialysis Transplantation. 35
Background and Aims Important mechanism associated to the development of Insulin resistance (IR) are dysregulation of lipid adjustment and excessive deposition of extracellular matrix (ECM) in the visceral white adipose tissue (WAT). The transgenic d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf7a9d6b426d9ed27647866e7ba449d7
https://doi.org/10.1093/ndt/gfaa142.p0992
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7
P0672CALPAINS 1 AND 2 ARE INCREASED DURING THE DEVELOPMENT OF CHRONIC KIDNEY DAMAGE IN MICE FED WITH AN ADENINE RICH DIET
Autor: Elena Gutiérrez-Calabrés, Manuel Rodríguez-Puyol, Sergio De Frutos García, Laura Calleros, Diego Rodríguez-Puyol, Mercedes Griera-Merino, Sofía Campillo de Blas, Diego García Ayuso, Lourdes Bohorquez Magro, David Vaillo
Publikováno v: Nephrology Dialysis Transplantation. 35
Background and Aims Calpains are intracellular cysteine proteases that play a critical role in cell remodeling, being involved in multiple biological processes linked to tissue damage and repair mechanisms. In addition, they are released into the cir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::941196c6b505d4039c6745eaff1f2708
https://doi.org/10.1093/ndt/gfaa142.p0672
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8
Tweak up-regulates endothelin-1 system in mouse and human endothelial cells
Autor: Patricia Martínez-Miguel, Alberto Ortiz, Susana López-Ongil, Manuel Rodríguez-Puyol, Diana Medrano-Andrés, Diego Rodríguez-Puyol, Mercedes Griera-Merino
Publikováno v: Cardiovascular Research. 113:207-221
Aim To analyse the ability of TWEAK to modify the endothelin system, particularly endothelin-1 (ET-1) and endothelin-converting enzyme-1 (ECE-1), studying the intracellular mechanisms implied. TNF-like weak inducer of apoptosis (TWEAK) is a member of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5275e46766b8d56fc04605c21954a81e
https://doi.org/10.1093/cvr/cvw239
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9
Experimental and DFT characterization, antioxidant and anticancer activities of a Cu(II)–irbesartan complex: structure–antihypertensive activity relationships in Cu(II)–sartan complexes
Autor: Mercedes Griera Merino, Evelina G. Ferrer, Patricia A.M. Williams, Carlos A. Franca, Manuel Rodríguez-Puyol, Laura Calleros, María Soledad Islas, Alicia Luengo, Luis Lezama
Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
The coordination compound of the antihypertensive ligand irbesartan (irb) with copper(II) (CuIrb) was synthesized and characterized by FTIR, FT-Raman, UV–visible, reflectance and EPR spectroscopies. Experimental evidence allowed the implementation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bda9c34591de3808a74d6d1482ecfcf
https://link.springer.com/article/10.1007/s00775-016-1384-5
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10
Improvement of the antihypertensive capacity of candesartan and trityl candesartan by their SOD mimetic copper(II) complexes
Autor: Manuel Rodríguez Puyol, Mercedes Griera Merino, Patricia A.M. Williams, Luis Lezama, Evelina G. Ferrer, Maria Alicia Cortes, Teófilo Rojo, María Soledad Islas
Two new complexes [Cu(Cand)(H2O)4] [1] and [Cu2(TCand)4(H2O)2]·4H2O [2] (Cand = candesartan; TCand = trityl candesartan) have been synthesized and thoroughly characterized. The FTIR, Raman, EPR and diffuse reflectance spectra of the solid compounds
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55603c4a8afbb8ac34f2ef6a5782249f
http://www.sciencedirect.com/science/article/pii/S0162013413000457
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