Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Mercedes Giralt"'
Autor:
Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Kevin Aguilar, Anna Escrig, Mercedes Giralt, Richard D. Palmiter, Juan Hidalgo
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Abstract Background Interleukin-6 (IL-6) is a pleiotropic cytokine that controls numerous physiological processes both in basal and neuroinflammatory conditions, including the inflammatory response to experimental autoimmune encephalomyelitis (EAE).
Externí odkaz:
https://doaj.org/article/aa6ec45c2d8d462f8f3b346cfb5ade88
Autor:
Anna Escrig, Amalia Molinero, Brenda Méndez, Mercedes Giralt, Gemma Comes, Paula Sanchis, Olaya Fernández-Gayol, Lydia Giménez-Llort, Christoph Becker-Pauly, Stefan Rose-John, Juan Hidalgo
Publikováno v:
Cells, Vol 9, Iss 7, p 1605 (2020)
Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems per se, are risk factors for AD, and cytokines such as int
Externí odkaz:
https://doaj.org/article/f0119cf623424638a6775d70f1955022
Autor:
Paula Sanchis, Olaya Fernández-Gayol, Gemma Comes, Anna Escrig, Mercedes Giralt, Richard D. Palmiter, Juan Hidalgo
Publikováno v:
Cells, Vol 9, Iss 2, p 330 (2020)
Background: Interleukin-6 (IL-6) is a pleiotropic and multifunctional cytokine that plays a critical role in induction of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). Although EAE has always been consider
Externí odkaz:
https://doaj.org/article/a5c7e7a834704924b6613252eeb8614c
Autor:
Amalia Molinero, Antonio Fernandez-Perez, Aina Mogas, Mercedes Giralt, Gemma Comes, Olaya Fernandez-Gayol, Mario Vallejo, Juan Hidalgo
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173675 (2017)
The aim of the present work was to further explore the physiological roles of muscle-derived IL-6. Adult-floxed and conditional skeletal muscle IL-6 knock out male and female mice were used to study energy expenditure (indirect calorimetry at rest an
Externí odkaz:
https://doaj.org/article/a13d43cf1ffa49109f09d0da2b06c28c
Autor:
Javier Carrasco, Milena Penkowa, Mercedes Giralt, Jordi Camats, Amalia Molinero, Iain L. Campbell, Richard D. Palmiter, Juan Hidalgo
Publikováno v:
Neurobiology of Disease, Vol 13, Iss 1, Pp 22-36 (2003)
We evaluated the physiological relevance of metallothionein-III (MT-III) in the central nervous system following damage caused by a focal cryolesion onto the cortex by studying Mt3-null mice. In normal mice, dramatic astrogliosis and microgliosis and
Externí odkaz:
https://doaj.org/article/8f9a25f27563409a83d67ccb1338e788
Autor:
Mercedes Giralt, Milena Penkowa, Joaquı́n Hernández, Amalia Molinero, Javier Carrasco, Natalia Lago, Jordi Camats, Iain L. Campbell, Juan Hidalgo
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 3, Pp 319-338 (2002)
Transgenic expression of IL-6 under the control of the GFAP gene promoter (GFAP-IL6 mice) in the CNS causes significant damage and alters the expression of many genes, including the metallothionein (MT) family, especially in the cerebellum. The cross
Externí odkaz:
https://doaj.org/article/7be510ecd7cc4dd0886de28be7c8477e
Autor:
Gemma Comes, Yasmina Manso, Anna Escrig, Olaya Fernandez-Gayol, Paula Sanchis, Amalia Molinero, Mercedes Giralt, Javier Carrasco, Juan Hidalgo
Publikováno v:
International Journal of Molecular Sciences, Vol 18, Iss 2, p 251 (2017)
The mouse model of Alzheimer’s disease (AD), Tg2576 mice (APP), has provided valuable information, such as the role of the metallothionein (MT) family in their behavioral and amyloidosis phenotypes. In this study, we further characterize the role o
Externí odkaz:
https://doaj.org/article/b55113948334475cbea5c55aedb36b7f
Publikováno v:
Brain Sciences, Vol 6, Iss 2, p 15 (2016)
Interleukin-6 (IL-6) is a multifunctional cytokine that not only plays major roles in the immune system, but also serves as a coordinator between the nervous and endocrine systems. IL-6 is produced in multiple cell types in the CNS, and in turn, many
Externí odkaz:
https://doaj.org/article/b3fe2159e6ea4e48870e252c91234aa5
Autor:
Carla Canal, Amalia Molinero, Juan Hidalgo, Joel Vizueta, Anna Escrig, Olaya Fernández-Gayol, Gemma Comes, Paula Sanchis, Mercedes Giralt
Publikováno v:
Glia. 68:999-1016
Traumatic brain injury (TBI) is a major health problem with high rates of mortality and morbidity worldwide. The response of the brain to TBI is orchestrated by a number of cytokines, including interleukin-6 (IL-6). IL-6 is a major cytokine in the ce
Autor:
Mercedes Giralt, Amalia Molinero, Christoph Becker-Pauly, Juan Hidalgo, Gemma Comes, Stefan Rose-John, Alejandro Montilla, Carla Canal, Anna Escrig, Paula Sanchis, Olaya Fernández-Gayol, Lydia Giménez-Llort
Publikováno v:
Brain, Behavior, and Immunity. 82:145-159
Alzheimer's disease (AD) is the most commonly diagnosed dementia but its underlying pathological mechanisms still unclear. Neuroinflammation and secretion of cytokines such as interleukin-6 (IL-6) accompany the main hallmarks of the disease: amyloid