Výsledky vyhledávání - "Mercedes F Rivera-Kweh"

Akademický článek

Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(null) Mice.

Autor: Irina M Velsko, Sasanka S Chukkapalli, Mercedes F Rivera-Kweh, Hao Chen, Donghang Zheng, Indraneel Bhattacharyya, Pandu R Gangula, Alexandra R Lucas, Lakshmyya Kesavalu

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129795 (2015)

The American Heart Association supports an association between periodontal disease (PD) and atherosclerotic vascular disease (ASVD) but does not as of yet support a causal relationship. Recently, we have shown that major periodontal pathogens Porphyr

Externí odkaz: https://doaj.org/article/ab90c8678825468f98713f0ddfbbee7e

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Akademický článek

Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE null Mice.

Autor: Sasanka S Chukkapalli, Irina M Velsko, Mercedes F Rivera-Kweh, Donghang Zheng, Alexandra R Lucas, Lakshmyya Kesavalu

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143291 (2015)

Periodontal disease (PD) develops from a synergy of complex subgingival oral microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). To investigate how a polybacterial microbiome infection influences atheroscleroti

Externí odkaz: https://doaj.org/article/f70a6a4c3faf4fd794165401227f0e31

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Global TLR2 and 4 deficiency in mice impacts bone resorption, inflammatory markers and atherosclerosis to polymicrobial infection

Autor: Sasanka S. Chukkapalli, Irina M. Velsko, Mercedes F. Rivera-Kweh, Alexandra Lucas, Hannu Larjava, Lakshmyya Kesavalu

Publikováno v: Molecular Oral Microbiology. 32:211-225

Summary Toll-like-receptors (TLRs) play a significant role in the generation of a specific innate immune response against invading pathogens. TLR2 and TLR4 signaling contributes to infection-induced inflammation in periodontal disease (PD) and athero

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e75dac0b87911f332de723e910bedb
https://doi.org/10.1111/omi.12165

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Periodontal Pathogens Invade Gingiva and Aortic Adventitia and Elicit Inflammasome Activation in αvβ6 Integrin-Deficient Mice

Autor: Irina M. Velsko, Sasanka S. Chukkapalli, Donghang Zheng, Mercedes F. Rivera-Kweh, Ikramuddin Aukhil, Alexandra Lucas, Hannu Larjava, Lakshmyya Kesavalu

Publikováno v: Infection and Immunity. 83:4582-4593

The American Heart Association supports an association between periodontal diseases and atherosclerosis but not a causal association. This study explores the use of the integrin β6 −/− mouse model to study the causality. We investigated the abil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83de45ea4e9f65277b3764539867d615
https://doi.org/10.1128/iai.01077-15

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Periodontitis in Rats Induces Systemic Oxidative Stress That Is Controlled by Bone-Targeted Antiresorptives

Autor: Irina M. Velsko, Sasanka S. Chukkapalli, L. Shannon Holliday, Sehkar Oktay, Mercedes F. Rivera-Kweh, Lakshmyya Kesavalu

Publikováno v: Journal of Periodontology. 86:137-145

Periodontitis is a chronic, polymicrobial inflammatory disease that degrades connective tissue and alveolar bone and results in tooth loss. Oxidative stress has been linked to the onset of periodontal tissue breakdown and systemic inflammation, and t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b9dbd909c68e2b7b3b386aa68691dc
https://doi.org/10.1902/jop.2014.140302

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Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms

Autor: Lakshmyya Kesavalu, Irina M. Velsko, Edward Kar Leung Chan, Premakumari Venkatesh, Thomas G. Gleason, Sasanka S. Chukkapalli, Ravi K. Ghanta, Seyed Hossein Aalaei-Andabili, Paul VanRyzin, Julie A. Phillippi, Mercedes F. Rivera-Kweh, Thomas M. Beaver

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 875
International Journal of Molecular Sciences, Vol 18, Iss 4, p 875 (2017)
International Journal of Molecular Sciences

Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e026c42c06382423510702ccd6382d

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Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

Autor: Irina M. Velsko, Prashasnika Gehlot, S. John Calise, Edward K. L. Chan, Indraneel Bhattacharyya, Joseph Holoshitz, Lakshmyya Kesavalu, Sasanka S. Chukkapalli, Mercedes F. Rivera-Kweh, Minoru Satoh

Publikováno v: Arthritis Research & Therapy

Background It has been previously hypothesized that oral microbes may be an etiological link between rheumatoid arthritis (RA) and periodontal disease. However, the mechanistic basis of this association is incompletely understood. Here, we investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8052081cb0249a76f54299867a06aa43
https://doi.org/10.1186/s13075-016-1056-4

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Abstract 14157: Periodontal Microbiome Induces Inflammation and Atherosclerosis in Hyperlipidemic Atherogenic Apoe Null Mice

Autor: Donghang Zheng, Sasanka S. Chukkapalli, Alexandra Lucas, Mercedes F. Rivera-Kweh, Irina M. Velsko, Kesavalu Lakshmyya

Publikováno v: Circulation. 132

Introduction: Periodontal disease (PD) is a polymicrobial dysbiotic chronic inflammatory disease produced by a complex subgingival microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (ASVD). American Heart Association

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49c0bf7bcbd0cb854b878f6cd71e0e75
https://doi.org/10.1161/circ.132.suppl_3.14157

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Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoEnull Mice

Autor: Alexandra Lucas, Irina M. Velsko, Lakshmyya Kesavalu, Mercedes F. Rivera-Kweh, Donghang Zheng, Sasanka S. Chukkapalli

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0143291 (2015)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae57f41b76ef10d452f2a956dd928f74
http://europepmc.org/articles/PMC4664240

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Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers

Autor: Hao Chen, Alexandra Lucas, Irina M. Velsko, Donghang Zheng, Pandu R. Gangula, Mercedes F. Rivera-Kweh, Sasanka S. Chukkapalli, Lakshmyya Kesavalu, Indraneel Bhattacharyya

Publikováno v: Pathogens and disease. 73(3)

Tannerella forsythia is a Gram-negative anaerobic organism that inhabits the subgingival cavity and initiates connective tissue destruction and alveolar bone resorption in periodontal disease (PD). PD is a chronic immunoinflammatory disease and has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b7c43a4aa193380033003d72d63d17e
https://pubmed.ncbi.nlm.nih.gov/25663343

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