Zobrazeno 1 - 10 of 33 pro vyhledávání: '"Mercedes Del Rio‐Moreno"'
1
Akademický článek
Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing
Autor: Juan L. López‐Cánovas, Natalia Hermán‐Sánchez, Maria Trinidad Moreno‐Montilla, Mercedes del Rio‐Moreno, Emilia Alors‐Perez, Marina E. Sánchez‐Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de laMata, Justo P. Castaño, Manuel Rodriguez‐Perálvarez, Raúl M. Luque, Manuel D. Gahete
Publikováno v: Clinical and Translational Medicine, Vol 12, Iss 11, Pp n/a-n/a (2022)
Abstract Introduction Altered splicing landscape is an emerging cancer hallmark; however, the dysregulation and implication of the cellular machinery controlling this process (spliceosome components and splicing factors) in hepatocellular carcinoma (
Externí odkaz: https://doaj.org/article/44c65a5a43f5401cba4cff96e19ce370
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2
Akademický článek
Changes in Splicing Machinery Components Influence, Precede, and Early Predict the Development of Type 2 Diabetes: From the CORDIOPREV StudyResearch in context
Autor: Manuel D. Gahete, Mercedes del Rio-Moreno, Antonio Camargo, Juan F. Alcala-Diaz, Emilia Alors-Perez, Javier Delgado-Lista, Oscar Reyes, Sebastian Ventura, Pablo Perez-Martínez, Justo P. Castaño, José Lopez-Miranda, Raul M. Luque
Publikováno v: EBioMedicine, Vol 37, Iss , Pp 356-365 (2018)
Background: Type-2 diabetes mellitus (T2DM) is a major health problem with increasing incidence, which severely impacts cardiovascular disease. Because T2DM is associated with altered gene expression and aberrant splicing, we hypothesized that dysreg
Externí odkaz: https://doaj.org/article/1ae63e0c33a644fe99dec914e4ccb96e
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3
Akademický článek
Towards Understanding the Direct and Indirect Actions of Growth Hormone in Controlling Hepatocyte Carbohydrate and Lipid Metabolism
Autor: Mari C. Vázquez-Borrego, Mercedes del Rio-Moreno, Rhonda D. Kineman
Publikováno v: Cells, Vol 10, Iss 10, p 2532 (2021)
Growth hormone (GH) is critical for achieving normal structural growth. In addition, GH plays an important role in regulating metabolic function. GH acts through its GH receptor (GHR) to modulate the production and function of insulin-like growth fac
Externí odkaz: https://doaj.org/article/ffa59f080fb949c391d11548a29c2c32
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5
PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing
Autor: Juan L. López-Cánovas, Natalia Hermán-Sánchez, Mercedes del Rio-Moreno, Antonio C. Fuentes-Fayos, Araceli Lara-López, Marina E. Sánchez-Frias, Víctor Amado, Rubén Ciria, Javier Briceño, Manuel de la Mata, Justo P. Castaño, Manuel Rodriguez-Perálvarez, Raúl M. Luque, Manuel D. Gahete
Publikováno v: Experimental & Molecular Medicine. 55:132-142
Hepatocellular carcinoma (HCC) pathogenesis is associated with alterations in splicing machinery components (spliceosome and splicing factors) and aberrant expression of oncogenic splice variants. We aimed to analyze the expression and potential role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::587a69fb88aa6a3e004817e5b25b6f3a
https://doi.org/10.1038/s12276-022-00917-7
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6
Growth Hormone Accelerates Recovery From Acetaminophen-Induced Murine Liver Injury
Autor: Elissa Everton, Mercedes Del Rio-Moreno, Carlos Villacorta-Martin, Pushpinder Singh Bawa, Jonathan Lindstrom-Vautrin, Hiromi Muramatsu, Fatima Rizvi, Anna R. Smith, Ying Tam, Norbert Pardi, Rhonda Kineman, David J. Waxman, Valerie Gouon-Evans
Publikováno v: bioRxiv
Background and AimsAcetaminophen (APAP) overdose is the leading cause of acute liver failure, with one available treatment, N-acetyl cysteine (NAC). Yet, NAC effectiveness diminishes about ten hours after APAP overdose, urging for therapeutic alterna
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005a87698cc25a2897b9bdef04429dd
https://europepmc.org/articles/PMC10153200/
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8
Constitutively Active STAT5b Feminizes Mouse Liver Gene Expression
Autor: Dana Lau-Corona, Hong Ma, Cameron Vergato, Andre Sarmento-Cabral, Mercedes del Rio-Moreno, Rhonda D Kineman, David J Waxman
Publikováno v: Endocrinology
STAT5 is an essential transcriptional regulator of the sex-biased actions of growth hormone (GH) in the liver. Delivery of constitutively active STAT5 (STAT5CA) to male mouse liver using an engineered adeno-associated virus with high tropism for the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be35c8d519ea27393c42263d609f7d1b
https://pubmed.ncbi.nlm.nih.gov/35396838
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10
Dysregulation of the Splicing Machinery Is Associated to the Development of Nonalcoholic Fatty Liver Disease
Autor: Manuel de la Mata, Rhonda D. Kineman, Manuel Rodríguez-Perálvarez, Marina E. Sánchez-Frías, Raúl M. Luque, Gustavo Ferrín, Rafael Sánchez-Sánchez, Sandra González-Rubio, Sebastián Ventura, Manuel D. Gahete, Mercedes del Rio-Moreno, Justo P. Castaño, Oscar Reyes, Jose Lopez-Miranda, Emilia Alors-Perez
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 104:3389-3402
Context Nonalcoholic fatty liver disease (NAFLD) is a common obesity-associated pathology characterized by hepatic fat accumulation, which can progress to fibrosis, cirrhosis, and hepatocellular carcinoma. Obesity is associated with profound changes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d74e3c70e1be5b1edd455435232a7bd
https://doi.org/10.1210/jc.2019-00021
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