The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology

Autor: Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions. As NKG2DLs are upregulated on tumor cells but tumors can subvert the NKG2

Externí odkaz: https://doaj.org/article/1adb248fdaf140c9b28258767763461f

Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1

Autor: Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Nicolás Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raúl Germán Spallanzani, Agustín Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is

Externí odkaz: https://doaj.org/article/7fcc502be5bf4a60b9407ff51b56cfca

Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.

Autor: Carolina Inés Domaica, Mercedes Beatriz Fuertes, Ignacio Uriarte, María Victoria Girart, Jessica Sardañons, Dorina Ileana Comas, Daniela Di Giovanni, María Isabel Gaillard, Liliana Bezrodnik, Norberto Walter Zwirner

Publikováno v: PLoS ONE, Vol 7, Iss 12, p e51677 (2012)

Two populations of human natural killer (NK) cells can be identified in peripheral blood. The majority are CD3(-)CD56(dim) cells while the minority exhibits a CD3(-)CD56(bright) phenotype. In vitro evidence indicates that CD56(bright) cells are precu

Externí odkaz: https://doaj.org/article/a069c881cd3c4465b0bced471eebf02e

Leveraging NKG2D Ligands in Immuno-Oncology

Autor: Norberto Walter Zwirner, Mercedes Beatriz Fuertes, Carolina Ines Domaica

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

Immune checkpoint inhibitors (ICI) revolutionized the field of immuno-oncology and opened new avenues towards the development of novel assets to achieve durable immune control of cancer. Yet, the presence of tumor immune evasion mechanisms represents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d79da142c76e1e4721742c07a7d4d8
https://doi.org/10.3389/fimmu.2021.713158

Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

Autor: Carolina Ines Domaica, Kenneth W. Hance, Constanza Lauché, Kevin P. Madauss, Florencia Secchiari, Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Fernando Alberto Goldbaum, Maria Cecilia Santilli, Nicolas Gilio, Sol Yanel Nuñez, Norberto Walter Zwirner, Evangelina Almada, Adrián Friedrich, Vanesa Zylberman, Mercedes Beatriz Fuertes, Jessica Mariel Sierra, Israel S. Gloger, Raul German Spallanzani, María Victoria Regge, Nicolás Torres, Romina Paola Pardo

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a807302989d0c0cff85e03dae050930d
https://jitc.bmj.com/content/8/1/e000233.full