Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Mercedes Alfonso-Prieto"'
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Acrylamide (ACR) is formed during food processing by Maillard reaction between sugars and proteins at high temperatures. It is also used in many industries, from water waste treatment to manufacture of paper, fabrics, dyes and cosmetics. Unfortunatel
Externí odkaz:
https://doaj.org/article/25190fba0fa14b9ba1e0c84163c23689
Autor:
Cristina Ortiz, Sabine Klein, Winfried H. Reul, Fernando Magdaleno, Stefanie Gröschl, Peter Dietrich, Robert Schierwagen, Frank E. Uschner, Sandra Torres, Christoph Hieber, Caroline Meier, Nico Kraus, Olaf Tyc, Maximilian Brol, Stefan Zeuzem, Christoph Welsch, Marco Poglitsch, Claus Hellerbrand, Mercedes Alfonso-Prieto, Fabio Mira, Ulrich auf dem Keller, Anja Tetzner, Andrew Moore, Thomas Walther, Jonel Trebicka
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112059- (2023)
Summary: Development of liver fibrosis is paralleled by contraction of hepatic stellate cells (HSCs), the main profibrotic hepatic cells. Yet, little is known about the interplay of neprilysin (NEP) and its substrate neuropeptide Y (NPY), a potent en
Externí odkaz:
https://doaj.org/article/5733bb5802fd4f15923c9bfe812518bf
Publikováno v:
Frontiers in Physics, Vol 10 (2022)
G-protein signaling pathways mediate communication across cell membranes. The first steps of this communication occur at the cell membrane, where upon receiving an external signal –the binding of an agonist ligand– the membrane-embedded G-Protein
Externí odkaz:
https://doaj.org/article/1906fc95ab93403ca8be5ba013c4a44a
Autor:
Victor A. Streltsov, Sukanya Luang, Alys Peisley, Joseph N. Varghese, James R. Ketudat Cairns, Sebastien Fort, Marcel Hijnen, Igor Tvaroška, Ana Ardá, Jesús Jiménez-Barbero, Mercedes Alfonso-Prieto, Carme Rovira, Fernanda Mendoza, Laura Tiessler-Sala, José-Emilio Sánchez-Aparicio, Jaime Rodríguez-Guerra, José M. Lluch, Jean-Didier Maréchal, Laura Masgrau, Maria Hrmova
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Enzyme substrates and products often diffuse too rapidly to assess the catalytic implications of these movements. Here, the authors characterise the structural basis of product and substrate diffusion for an exo-hydrolase and discover a substrate-pro
Externí odkaz:
https://doaj.org/article/393023e627f645a0b2087690681cc2f6
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Hybrid Molecular Mechanics/Coarse-Grained (MM/CG) simulations help predict ligand poses in human G protein-coupled receptors (hGPCRs), the most important protein superfamily for pharmacological applications. This approach allows the description of th
Externí odkaz:
https://doaj.org/article/6a5c86fe5c2f413194c0a585bbca024b
Publikováno v:
Journal of Science: Advanced Materials and Devices, Vol 2, Iss 1, Pp 15-21 (2017)
Human bitter taste receptors (hTAS2Rs) are the second largest group of chemosensory G-protein coupled receptors (25 members). hTAS2Rs are expressed in many tissues (e.g. tongue, gastrointestinal tract, respiratory system, brain, etc.), performing a v
Externí odkaz:
https://doaj.org/article/b980a2a0b74f4920bc7a6a71124ab2ee
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Human G-protein coupled receptors (GPCRs) convey a wide variety of extracellular signals inside the cell and they are one of the main targets for pharmaceutical intervention. Rational drug design requires structural information on these receptors; ho
Externí odkaz:
https://doaj.org/article/15b34549da2344b5b738d41b6f98524d
Autor:
Fabrizio Fierro, Eda Suku, Mercedes Alfonso-Prieto, Alejandro Giorgetti, Sven Cichon, Paolo Carloni
Publikováno v:
Frontiers in Molecular Biosciences, Vol 4 (2017)
Human G-protein coupled receptors (hGPCRs) constitute a large and highly pharmaceutically relevant membrane receptor superfamily. About half of the hGPCRs' family members are chemosensory receptors, involved in bitter taste and olfaction, along with
Externí odkaz:
https://doaj.org/article/02f2eb9919d5481bbaa1eb38a039417e
Autor:
Mercedes Alfonso-Prieto, Irene Cuxart, Gabrielle Potocki-Véronèse, Isabelle André, Carme Rovira
Publikováno v:
ACS catalysis 13, 4283-4289 (2023). doi:10.1021/acscatal.3c00451
The unknown human gut bacterium mannoside phosphorylase (UhgbMP) is involved in the metabolization of eukaryotic N-glycans lining the intestinal epithelium, a factor associated with the onset and symptoms of inflammatory bowel diseases. In contrast w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b98e387cacf2179b8f83412c94b630d
https://doi.org/10.1021/acscatal.3c00451
https://doi.org/10.1021/acscatal.3c00451
Publikováno v:
Journal of chemical information and modeling 63(10), 2911-2917 (2023). doi:10.1021/acs.jcim.3c00380
Atomistic-level investigation of olfactory receptors (ORs) is a challenging task due to the experimental/computational difficulties in the structural determination/prediction for members of this family of G-protein coupled receptors. Here, we have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dd512a172afeb5bdbbc4579cfa5f6b5
https://doi.org/10.1101/2023.02.22.529484
https://doi.org/10.1101/2023.02.22.529484
