Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Mercedes A, Gacad"'
1
Identification of a competitive binding component in vitamin D-resistant new world primate cells with a low affinity but high capacity for 1,25-dihydroxyvitamin D3
Autor: Mercedes A. Gacad, John S. Adams
Publikováno v: Journal of Bone and Mineral Research. 8:27-35
Monkeys in a number of different New World primate genera express a form of compensated target organ resistance to steroid hormones, including 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Characterization of these phenotypes has previously relied upon th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727b17d259cae780ae6080183c1d20f8
https://doi.org/10.1002/jbmr.5650080105
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2
Substrate and Enzyme Trafficking as a Means of Regulating 1,25-Dihydroxyvitamin D Synthesis and Action: The Human Innate Immune Response
Autor: Jonathan P. Ride, Shaoxing Wu, Robert L. Modlin, Songyang Ren, Hong Chen, Martin Hewison, Mercedes A. Gacad, Rene F. Chun, John S. Adams, Philip T. Liu, Lisa Nguyen
Publikováno v: Journal of Bone and Mineral Research. 22:V20-V24
Tissue availability of the active vitamin D metabolite, 1,25-dihydroxyvitamin D [1,25(OH)(2)D] is dependent on expression of the activating enzyme 1alpha-hydroxylase (CYP27b1) and its catabolic counterpart 24-hydroxylase (CYP24). The activity of thes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4783f64eeca16ba1e49503021d288b85
https://doi.org/10.1359/jbmr.07s214
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3
Adenosine 5′-Triphosphate-Dependent Vitamin D Sterol Binding to Heat Shock Protein-70 Chaperones
Autor: Mercedes A. Gacad, Rene F. Chun, John S. Adams, Martin Hewison
Publikováno v: Endocrinology. 146:5540-5544
Chaperone proteins in the heat shock protein-70 family possess endogenous ATP binding and ATPase activity and interact with intracellular protein substrates in an ATP-dependent manner; the hydrolysis of ATP to ADP results in an increase in the affini
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::555b69c36ba920af3c77e5270f217ffd
https://doi.org/10.1210/en.2005-0579
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4
Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
Autor: Carlos Encinas, Julia Barsony, Hong Chen, Rene F. Chun, Songyang Ren, Martin Hewison, Lisa Nguyen, Shaoxing Wu, Mercedes A. Gacad, John S. Adams
Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. :461-465
Using vitamin D-resistant New World primates as model of natural diversity for sterol/steroid action and metabolism, two families of novel intracellular vitamin D regulatory proteins have been discovered and their human homologs elucidated. The first
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ccd9c98e6c8dc964cd6a3a30387687
https://doi.org/10.1016/j.jsbmb.2004.03.016
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5
Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo
Autor: Shaoxing Wu, Songyang Ren, Hong Chen, J. Barsony, Lisa Nguyen, Rene F. Chun, John S. Adams, Mercedes A. Gacad
Publikováno v: Journal of Cellular Biochemistry. 88:308-314
We undertook an investigation of an outbreak of rachitic bone disease in the Emperor Tamarin New World primate colony at the Los Angeles Zoo in the mid-1980s. The disease phenotype resembled that observed in humans with an inactivating mutation of th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::100f7cbbe108e602c56948cd4e51934f
https://doi.org/10.1002/jcb.10333
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7
Proteins in the Heat Shock-70 Family Specifically Bind 25-Hydroxyvitamin D3and 17β-Estradiol1
Autor: John S. Adams, Mercedes A. Gacad
Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:1264-1267
Most New World primates evolved to express a form of compensated resistance to steroid hormones from the gonads and adrenal glands as well as to the hydroxylated vitamin D3 prohormone, 25-hydroxyvitamin D3 (25OHD3), and the vitamin D hormone 1,25-dih
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae85cf6385fd4152b9334a21fa4cce92
https://doi.org/10.1210/jcem.83.4.4725
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8
Functional Characterization and Purification of an Intracellular Vitamin D-binding Protein in Vitamin D-resistant New World Primate Cells
Autor: John S. Adams, Thomas R. Lebon, Mercedes A. Gacad, Hong Chen, Jonathan E. Arbelle
Publikováno v: Journal of Biological Chemistry. 272:8433-8440
Most genera of New World primates exhibit resistance to vitamin D. These monkeys harbor high circulating concentrations of the prohormone 25-hydroxyvitamin D and the active vitamin D hormone 1,25-dihydroxyvitamin D. Previous work from this laboratory
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::704955e19691bdcb5e1808a6137a522f
https://doi.org/10.1074/jbc.272.13.8433
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9
Vitamin D and gonadal steroid-resistant New World primate cells express an intracellular protein which competes with the estrogen receptor for binding to the estrogen response element
Autor: Hong Chen, Jonathan E. Arbelle, John S. Adams, Elizabeth A. Allegretto, Mercedes A. Gacad
Publikováno v: Journal of Clinical Investigation. 99:669-675
New World primates (NWP) exhibit a form of compensated resistance to vitamin D and other steroid hormones, including 17beta-estradiol. One postulated cause of resistance is that NWP cells overexpress one or more proteins which block hormone action by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6040a3134911593ef290d3d13ce548
https://doi.org/10.1172/jci119210
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10
Absence of thyroid hormone resistance in vitamin D-;resistant new world primates
Autor: Mercedes A. Gacad, Jonathan E. Arbelle, John S. Adams, Carole A. Spencer
Publikováno v: American Journal of Primatology. 32:215-222
New World primates express a form of sterol/steroid resistance resulting from the presence of a 58-60 kDa intracellular protein (IDBP) which competes with nuclear receptor proteins for binding of vitamin D metabolites and sex steroids. As the thyroid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dbaeb85193d964f80979316bffaabf7
https://doi.org/10.1002/ajp.1350320308
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