Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mercedes, Lobera"'
Autor:
Paul A. Wilson, Sara Santos Franco, Liu He, Nicholas W. Galwey, Jackie Meakin, Rebecca McIntyre, Simon M. McHugh, Michael A. Nolan, Sarah L. Spain, Thaddeus Carlson, Mercedes Lobera, Justin P. Rubio, Bill Davis, Linda C. McCarthy
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prior
Externí odkaz:
https://doaj.org/article/379c1f72bac84bec9638d701c7a4dcef
Autor:
Simon M. McHugh, Bill Davis, Liu He, Jackie Meakin, Paul A. Wilson, Sara Santos Franco, Thaddeus J. Carlson, Mercedes Lobera, Linda McCarthy, Justin P. Rubio, Sarah L. Spain, Rebecca E. McIntyre, Michael A. Nolan, Nicholas Galwey
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258316 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prior
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a51219a1299e5099e5290fcffc62fa
https://doaj.org/article/9579a389fd9d4fd68176d966c4cda4dc
https://doaj.org/article/9579a389fd9d4fd68176d966c4cda4dc
Autor:
Xiaoxia Song, Feng Ren, Qian Liu, Yafei Huang, Wei Cai, Zhijun Xiang, Jia-Ning Xiang, Tang Ting, Qianqian Wu, Yingli Ma, Xichen Lin, Mercedes Lobera, Guifeng Zhang, Ling Zhou, Liming Shao, Ting Yang, Stewart Leung, Liuqing Yang, Wang Yonghui, Lisa A. Orband-Miller
Publikováno v:
ACS Medicinal Chemistry Letters. 9:120-124
Biaryl amides as new RORγt modulators were discovered. The crystal structure of biaryl amide agonist 6 in complex with RORγt ligand binding domain (LBD) was resolved, and both “short” and “long” inverse agonists were obtained by removing fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a87da15f60b2a1ed850fe7080392df
https://doi.org/10.1021/acsmedchemlett.7b00476
https://doi.org/10.1021/acsmedchemlett.7b00476
Autor:
Scott B. Snapper, Shomir Ghosh, Diane Mathis, Christophe Benoist, Ray Jupp, Ashlee M. Earl, Liza Konnikova, David Zemmour, Adriana Ortiz-Lopez, Dennis L. Kasper, Dalia Burzyn, Abigail Manson McGuire, Sungwhan F. Oh, Naama Geva-Zatorsky, Mercedes Lobera, Jianfei Yang, Esen Sefik
Publikováno v:
Science. 349:993-997
Gut microbes make T cells keep the peace Our guts harbor trillions of microbial inhabitants, some of which regulate the types of immune cells that are present in the gut. For instance, Clostridium species of bacteria induce a type of T cell that prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe4372d523ec4990b3505e7d4946062
https://doi.org/10.1126/science.aaa9420
https://doi.org/10.1126/science.aaa9420
Autor:
Jerome Ritz, Patrick Blanco, Di Jiang, Corey Cutler, Tohti Amet, Sophie Paczesny, Kelli P. A. MacDonald, Hong Wei Chu, Giorgos Bakoyannis, Jianfei Yang, Katelyn Paz, Kate H. Gartlan, Brad Griesenauer, Jonathan S. Serody, Mercedes Lobera, Ryan Flynn, Joseph H. Antin, Eduardo Espada, John Koreth, Liangyi Liu, David S. Wilkes, Jing Du, Wei Li, Robert J. Soiffer, Bruce R. Blazar, Edouard Forcade, Geoffrey R. Hill
Publikováno v:
JCI Insight. 2
Chronic graft-versus-host disease (cGvHD) remains a major complication of allogeneic stem cell transplantation requiring novel therapies. CD146 and CCR5 are expressed by activated T cells and associated with increased T cell migration capacity and Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82fd0adce3520fb473c21b1849356214
https://doi.org/10.1172/jci.insight.92111
https://doi.org/10.1172/jci.insight.92111
Autor:
Rachel R. Caspi, Wambui S. Wandu, Lin Lu, Jianfei Yang, Mercedes Lobera, Igal Gery, Guangpu Shi, Biying Xu, So Jin Bing, Cancan Lyu, Samuel J. H. Hinshaw
Publikováno v:
European journal of immunology. 48(11)
Experimental autoimmune uveitis (EAU), an animal model for severe intraocular inflammatory eye diseases, is mediated by both Th1 and Th17 cells. Here, we examined the capacity of TMP778, a selective inhibitor of RORγt, to inhibit the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae44479733caf73f8bd6bea589409dc3
https://pubmed.ncbi.nlm.nih.gov/30218573
https://pubmed.ncbi.nlm.nih.gov/30218573
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec65053b42fd78ff43551db09ab31607
https://doi.org/10.4049/jimmunol.1302190
https://doi.org/10.4049/jimmunol.1302190
Autor:
Suzan Lazo, Alexandra Pourzia, Shawn F. Johnson, Mercedes Lobera, Jessica A. Castrillon, Ruben D. Carrasco, Anthony Letai, Jennifer L. Guerriero, Scott Davis, Sara Schad, Michael A. Nolan, Alaba Sotayo, Roderick T. Bronson, Holly Ponichtera
Publikováno v:
Nature. 543(7645)
Although the main focus of immuno-oncology has been manipulating the adaptive immune system, harnessing both the innate and adaptive arms of the immune system might produce superior tumour reduction and elimination. Tumour-associated macrophages ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34768c6f8fd70143a789df5f5c75138d
https://pubmed.ncbi.nlm.nih.gov/28552905
https://pubmed.ncbi.nlm.nih.gov/28552905
Autor:
Hugo M. Vargas, Yang Xu, Jerry Siu, Janet Buys, Michelle Horner, Jian Lin, Ashis Saha, Han Xu, Michele McElvain, Anurag Sharadendu, Scot Middleton, Roland Burli, Yael Marantz, Dalia Segal, Kevin Salyers, Mercedes Lobera, Dilara Mccauley, Srinivas Chereku, Xiang Yu, Nili Schutz, Michael Schrag
Publikováno v:
ACS Medicinal Chemistry Letters. 2:97-101
We have discovered novel benzofuran-based S1P1 agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P1 agonist with >1000× selectivity over S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8291efcc95ecdaf3a6ce8e57343599
https://doi.org/10.1021/ml100227q
https://doi.org/10.1021/ml100227q
Publikováno v:
The Journal of Organic Chemistry. 68:6451-6454
EtAlCl(2)-induced cyclization of chiral gamma,delta-unsaturated ketones 11c and 17b takes place mainly from the expected face. The selectivity is modest for 11c (60:40) in which the large substituent is a primary alkyl group and the medium substituen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654cf0f8b277d89384c519e7671235ee
https://doi.org/10.1021/jo034561v
https://doi.org/10.1021/jo034561v