Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Mercedes, Garayoa"'
Autor:
Andrea Díaz-Tejedor, Javier Rodríguez-Ubreva, Laura Ciudad, Mauro Lorenzo-Mohamed, Marta González-Rodríguez, Bárbara Castellanos, Janet Sotolongo-Ravelo, Laura San-Segundo, Luis A. Corchete, Lorena González-Méndez, Montserrat Martín-Sánchez, María-Victoria Mateos, Enrique M. Ocio, Mercedes Garayoa, Teresa Paíno
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 9, p 4718 (2024)
Multiple myeloma is a malignancy characterized by the accumulation of malignant plasma cells in bone marrow and the production of monoclonal immunoglobulin. A hallmark of cancer is the evasion of immune surveillance. Histone deacetylase inhibitors ha
Externí odkaz:
https://doaj.org/article/1dd5602bc30b4b36a56ce6c19c284a7a
Autor:
Antonio Garcia-Gomez, Tianlu Li, Carlos de la Calle-Fabregat, Javier Rodríguez-Ubreva, Laura Ciudad, Francesc Català-Moll, Gerard Godoy-Tena, Montserrat Martín-Sánchez, Laura San-Segundo, Sandra Muntión, Xabier Morales, Carlos Ortiz-de-Solórzano, Julen Oyarzabal, Edurne San José-Enériz, Manel Esteller, Xabier Agirre, Felipe Prosper, Mercedes Garayoa, Esteban Ballestar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Mesenchymal stromal cells (MSCs) have been shown to support multiple myeloma (MM) development. Here, MSCs isolated from the bone marrow of MM patients are shown to have altered DNA methylation patterns and a methyltransferase inhibitor reverts MM-ass
Externí odkaz:
https://doaj.org/article/97c0cd9d38aa419d8042bda6761115e0
Autor:
Esperanza M Algarín, Andrea Díaz-Tejedor, Pedro Mogollón, Susana Hernández-García, Luis A. Corchete, Laura San-Segundo, Montserrat Martín-Sánchez, Lorena González-Méndez, Marie Schoumacher, Sebastien Banquet, Laurence Kraus-Berthier, Ioana Kloos, Alix Derreal, Ensar Halilovic, Heiko Maacke, Norma C. Gutiérrez, María-Victoria Mateos, Teresa Paíno, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Externí odkaz:
https://doaj.org/article/512f9175196b4277b36f9d7dcf905aba
Autor:
Ana-Alicia López-Iglesias, Ana B. Herrero, Marta Chesi, Laura San-Segundo, Lorena González-Méndez, Susana Hernández-García, Irena Misiewicz-Krzeminska, Dalia Quwaider, Montserrat Martín-Sánchez, Daniel Primo, Teresa Paíno, P. Leif Bergsagel, Thomas Mehrling, Marcos González-Díaz, Jesús F. San-Miguel, María-Victoria Mateos, Norma C. Gutiérrez, Mercedes Garayoa, Enrique M. Ocio
Publikováno v:
Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-14 (2017)
Abstract Background Despite recent advances in the treatment of multiple myeloma (MM), the prognosis of most patients remains poor, and resistance to traditional and new drugs frequently occurs. EDO-S101 is a novel therapeutic agent conceived as the
Externí odkaz:
https://doaj.org/article/bfebf6dd497c42b797a071d86cc0e1d4
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Purpose: PIM kinases are a family of serine/threonine kinases recently proposed as therapeutic targets in oncology. In the present work, we have investigated the effects of the novel pan-PIM kinase inhibitor, PIM447, on myeloma cells and myeloma-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c4e842dd6ae86666bf855ccba83042
https://doi.org/10.1158/1078-0432.c.6526520.v1
https://doi.org/10.1158/1078-0432.c.6526520.v1
Autor:
Enrique M. Ocio, Mercedes Garayoa, María-Victoria Maetos, Norma C. Gutiérrez, Luis A. Corchete, Carlos Ortiz-de-Solorzano, David Corbacho, Montserrat Martín-Sánchez, Esperanza M. Algarín, Ana-Alicia López-Iglesias, Susana Hernández-García, Laura San-Segundo, Lorena González-Méndez, Antonio Garcia-Gomez, Teresa Paíno
Supplementary Figure 1. Evaluation of apoptosis and cell cycle in MM cell lines after PIM447 treatment. -Supplementary Figure 2. PIM447 very strongly synergizes with different antimyeloma agents in the RPMI-8226 cell line. -Supplementary Figure 3. Ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c679e19e1bf938a3b2b16c8ee51060
https://doi.org/10.1158/1078-0432.22467035
https://doi.org/10.1158/1078-0432.22467035
Autor:
Kenneth C. Anderson, Jesus F. San-Miguel, Faustino Mollinedo, Paul G. Richardson, M. Victoria Mateos, Glynn Faircloth, Gabriel Otero, Pablo Aviles, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Ciaran J. McMullan, Nicholas Mitsiades, Juan Carlos Montero, David Vilanova, Mercedes Garayoa, Consuelo Gajate, Patricia Maiso, Atanasio Pandiella, Enrique M. Ocio, Constantine S. Mitsiades
Supplementary Figure 7 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d93fdc70d1fc34c26e9e4000250f183
https://doi.org/10.1158/0008-5472.22375193
https://doi.org/10.1158/0008-5472.22375193
Autor:
Kenneth C. Anderson, Jesus F. San-Miguel, Faustino Mollinedo, Paul G. Richardson, M. Victoria Mateos, Glynn Faircloth, Gabriel Otero, Pablo Aviles, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Ciaran J. McMullan, Nicholas Mitsiades, Juan Carlos Montero, David Vilanova, Mercedes Garayoa, Consuelo Gajate, Patricia Maiso, Atanasio Pandiella, Enrique M. Ocio, Constantine S. Mitsiades
Supplementary Table 2 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0917c0040561e46d8186cc3a1ecd2b7d
https://doi.org/10.1158/0008-5472.22375178.v1
https://doi.org/10.1158/0008-5472.22375178.v1
Autor:
Kenneth C. Anderson, Jesus F. San-Miguel, Faustino Mollinedo, Paul G. Richardson, M. Victoria Mateos, Glynn Faircloth, Gabriel Otero, Pablo Aviles, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Ciaran J. McMullan, Nicholas Mitsiades, Juan Carlos Montero, David Vilanova, Mercedes Garayoa, Consuelo Gajate, Patricia Maiso, Atanasio Pandiella, Enrique M. Ocio, Constantine S. Mitsiades
Despite recent progress in its treatment, multiple myeloma (MM) remains incurable, thus necessitating identification of novel anti-MM agents. We report that the marine-derived cyclodepsipeptide Aplidin exhibits, at clinically achievable concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a48c44ed3fb2cbcb24cfd7d40c4b81e
https://doi.org/10.1158/0008-5472.c.6497732
https://doi.org/10.1158/0008-5472.c.6497732
Autor:
Kenneth C. Anderson, Jesus F. San-Miguel, Faustino Mollinedo, Paul G. Richardson, M. Victoria Mateos, Glynn Faircloth, Gabriel Otero, Pablo Aviles, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Ciaran J. McMullan, Nicholas Mitsiades, Juan Carlos Montero, David Vilanova, Mercedes Garayoa, Consuelo Gajate, Patricia Maiso, Atanasio Pandiella, Enrique M. Ocio, Constantine S. Mitsiades
Supplementary Figure 2 from Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749eeaca36fe80cd287474710cee0716
https://doi.org/10.1158/0008-5472.22375211
https://doi.org/10.1158/0008-5472.22375211