Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Merced M. Leiker"'
Publikováno v:
Stem Cells International, Vol 2016 (2016)
A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injec
Externí odkaz:
https://doaj.org/article/9cf178ae2bff44daa17baeaf5e7a3484
Autor:
Gen Suzuki, Brian R Weil, Merced M Leiker, Amanda E Ribbeck, Rebeccah F Young, Thomas R Cimato, John M Canty
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113009 (2014)
Cardiosphere-derived cells (CDCs) improve ventricular function and reduce fibrotic volume when administered via an infarct-related artery using the "stop-flow" technique. Unfortunately, myocyte loss and dysfunction occur globally in many patients wit
Externí odkaz:
https://doaj.org/article/284f92a0ce214e119953e16fb3e7a9a8
Autor:
Maria Rodríguez-Gonzalez, Bruce R. Troen, Merced M Leiker, Manhui Pang, Zachary Sheridan, Norma J. Nowak, Jonathan E. Bard, Kenneth L. Seldeen, Mireya Hernandez
Publikováno v:
Aging (Albany NY)
Vitamin D insufficiency (serum 25-OH vitamin D < 30 ng/ml) affects 70-80% of the general population, yet the long-term impacts on physical performance and the progression of sarcopenia are poorly understood. We therefore followed 6-month-old male C57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64473c75ce8fe496aa0b159f9d2c49e
https://doi.org/10.18632/aging.101471
https://doi.org/10.18632/aging.101471
Autor:
Yonas Redae, Andrew Dynka, Aref Shahini, Kenneth L. Seldeen, Stelios T. Andreadis, Merced M Leiker, Ramkumar Thiyagarajan, Nika Rajabian, Bruce R. Troen
Publikováno v:
Nutrition
Objectives Nicotinamide adenine dinucleotide (NAD+), an essential cofactor for mitochondrial function, declines with aging, which may lead to impaired physical performance. Nicotinamide riboside (NR), a NAD+ precursor, restores cellular NAD+ levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fd33f3f432c3c099676bb60cb607ee
https://doi.org/10.1016/j.nut.2021.111189
https://doi.org/10.1016/j.nut.2021.111189
Autor:
Manhui Pang, Ginger Lasky, Merced M Leiker, Bruce R. Troen, Kirkwood E. Personius, Kenneth L. Seldeen
Publikováno v:
The Journals of Gerontology: Series A. 73:429-437
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365e2d48b7e1392c180e74f49f4f2c25
https://doi.org/10.1093/gerona/glx120
https://doi.org/10.1093/gerona/glx120
Autor:
Bruce R. Troen, Reem Nagi Berman, Ramkumar Thiyagarajan, Merced M Leiker, Yonas Redae, Kenneth L. Seldeen
Publikováno v:
Mech Ageing Dev
Frailty syndrome increases the risk for disability and mortality, and is a major health concern amidst the geriatric shift in the population. High intensity interval training (HIIT), which couples bursts of vigorous activity interspersed with active
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb10af77957d1dc11e1477990d4e7d47
https://europepmc.org/articles/PMC9841971/
https://europepmc.org/articles/PMC9841971/
Autor:
Kenneth L. Seldeen, Yonas Redae, Merced M Leiker, Ramkumar Thiyagarajan, Bruce R. Troen, Reem Nagi Berman
Publikováno v:
J Vis Exp
High intensity interval training (HIIT) is emerging as a therapeutic approach to prevent, delay, or ameliorate frailty. In particular short session HIIT, with regimens less than or equal to 10 min is of particular interest as several human studies fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6984bed21b4095584bb19877a39228
https://pubmed.ncbi.nlm.nih.gov/30774134
https://pubmed.ncbi.nlm.nih.gov/30774134
Publikováno v:
Circulation Research. 117:634-644
Rationale: Allogeneic bone marrow–derived mesenchymal stem cells (MSCs) and cardiosphere-derived cells (CDCs) have each entered clinical trials, but a direct comparison of these cell types has not been performed in a large animal model of hibernati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd6656b841d55cf94c72deba81f15630
https://doi.org/10.1161/circresaha.115.306850
https://doi.org/10.1161/circresaha.115.306850
Publikováno v:
Stem Cells International, Vol 2016 (2016)
Stem Cells International
Stem Cells International
A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbff4ebe77de7ff0b89a245793ee9e81
Publikováno v:
Circulation Research. 117
Objective: Virtually all large animal studies of cell-based therapy have employed young donor-recipient pairs. Since aging may impact the reparative ability of allogeneic cardiosphere-derived cells (CDCs), we tested whether CDCs from an aged donor pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd6a690ca5ca03b8418ad4e0ec583fde
https://doi.org/10.1161/res.117.suppl_1.154
https://doi.org/10.1161/res.117.suppl_1.154