Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mercè de Frias"'
Autor:
Maria J. Blanco-Prieto, Miguel A. Campanero, Dolors Colomer, Joan Gil, Gaël Roué, Mercè de Frias, Janny A. Villa-Pulgarin, Ander Estella-Hermoso de Mendoza, Consuelo Gajate, Janis de la Iglesia-Vicente, Faustino Mollinedo
Supplementary Data from In vitro and In vivo Selective Antitumor Activity of Edelfosine against Mantle Cell Lymphoma and Chronic Lymphocytic Leukemia Involving Lipid Rafts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb4dc2f3d768d1429e65e103d55b907
https://doi.org/10.1158/1078-0432.22442483
https://doi.org/10.1158/1078-0432.22442483
Autor:
Maria J. Blanco-Prieto, Miguel A. Campanero, Dolors Colomer, Joan Gil, Gaël Roué, Mercè de Frias, Janny A. Villa-Pulgarin, Ander Estella-Hermoso de Mendoza, Consuelo Gajate, Janis de la Iglesia-Vicente, Faustino Mollinedo
Purpose: Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) remain B-cell malignancies with limited therapeutic options. The present study investigates the in vitro and in vivo effect of the phospholipid ether edelfosine (1-O-octadecyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1424193ed353f8009e2c4a362c09355
https://doi.org/10.1158/1078-0432.c.6519200.v1
https://doi.org/10.1158/1078-0432.c.6519200.v1
Autor:
Mercè de Frias, Daniel Iglesias-Serret, Ana M. Cosialls, Llorenç Coll-Mulet, Antonio F. Santidrián, Diana M. González-Gironès, Esmeralda de la Banda, Gabriel Pons, Joan Gil
Publikováno v:
Haematologica, Vol 94, Iss 12 (2009)
Background The phosphatidylinositol-3-kinase/Akt pathway has been described to be critical in the survival of chronic lymphocytic leukemia cells. In this study we analyzed the effect of two selective chemical inhibitors of Akt (Akti-1/2 and A-443654)
Externí odkaz:
https://doaj.org/article/b17dc3945ebd491d8f5bd27f0e230eb1
Autor:
Antonio F. Santidrián, Ana M. Cosialls, Llorenç Coll-Mulet, Daniel Iglesias-Serret, Mercè de Frias, Diana M. González-Gironès, Clara Campàs, Alicia Domingo, Gabriel Pons, Joan Gil
Publikováno v:
Haematologica, Vol 92, Iss 12 (2007)
Background and Objectives The potential anticancer agent 1-(2-chlorophenyl-N-methylpropyl)-3-isoquinolinecarboxamide (PK11195), a translocator protein (18KDa) (TSPO) ligand, facilitates the induction of cell death by a variety of cytotoxic and chemot
Externí odkaz:
https://doaj.org/article/c8ae7d34cb924644b8793eaf896ba511
Autor:
Georgina Sorrosal, Juan F. Espinosa-Parrilla, Marco Pugliese, Javier Bustos, Mercè de Frias, Clara Campàs
Publikováno v:
Advances in Neuroimmune Biology. 4:187-204
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central nervous system (CNS) that causes significant disability. Immunosuppressive and immunomodulatory drugs have been designed for years to treat MS, as it was consid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cddfd099ccb514ad7fe23ad71ac6c2b
https://doi.org/10.3233/nib-130066
https://doi.org/10.3233/nib-130066
Autor:
Mercè de Frias, Joan Gil, Ana M. Cosialls, Gabriel Pons, Anna Menoyo, Javier Grau, Llorenç Coll-Mulet, Antonio F. Santidrian, Eva González-Barca, Daniel Iglesias-Serret, Alicia Domingo
Publikováno v:
British Journal of Haematology. 142:793-801
Chronic lymphocytic leukaemia (CLL) is the commonest form of leukaemia in adults in Western countries. We performed multiplex ligation-dependent probe amplification (MLPA) analysis in 50 CLL patients to identify multiple genomic CLL-specific targets,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e5cee138eb227c1d009638bd7e166a
https://doi.org/10.1111/j.1365-2141.2008.07268.x
https://doi.org/10.1111/j.1365-2141.2008.07268.x
Autor:
Montserrat Barragán, Mercè de Frias, Llorenç Coll-Mulet, Alicia Domingo, Daniel Iglesias-Serret, Clara Campàs, Gabriel Pons, Esther Castaño, Lyubomir T. Vassilev, Joan Gil, Ana M. Cosialls, Alberto Fernández de Sevilla, Antonio F. Santidrian
Publikováno v:
Blood. 107:4109-4114
B-cell chronic lymphocytic leukemia (B-CLL) is characterized by the accumulation of long-lived CD5+ B lymphocytes. Several drugs currently used in the therapy of B-CLL act, at least partially, through activation of the p53 pathway. Recently, nongenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79f0c3b3fb8b5f9646f5d187956ba14
https://doi.org/10.1182/blood-2005-08-3273
https://doi.org/10.1182/blood-2005-08-3273
Autor:
Andrew Saunders, Eric Van Den Neste, Pierre Zachee, Ann Janssens, Bruno Cazin, Eva González-Barca, Jaime Pérez de Oteyza, María José Terol, Clara Campàs, Vincent Levy, Mercè de Frias
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose Acadesine has shown in vitro to selectively induce apoptosis in B cells from chronic lymphocytic leukemia (CLL) patients. We conducted a phase I/II open-label clinical study, to determine the safety and tolerability of acadesine given intrave
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e8ae692ac15bd0792db31c21f342f9
https://pubmed.ncbi.nlm.nih.gov/23228986
https://pubmed.ncbi.nlm.nih.gov/23228986
Autor:
Camila Rubio-Patiño, Llorenç Coll-Mulet, Ana M. Cosialls, Daniel Iglesias-Serret, Alberto Fernández de Sevilla, Joan Gil, Mercè de Frias, Alba Pérez-Perarnau, Esmeralda de la Banda, Diana M. González-Gironès, Gabriel Pons
Publikováno v:
Epigenetics. 6(10)
Histone deacetylases (HDACs) play a key role in the regulation of acetylation status not only of histones but also of many other non-histone proteins involved in cell cycle regulation, differentiation or apoptosis. Therefore, histone deacetylase inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709e22bb06be1c72763e2e61bf66f0ad
https://pubmed.ncbi.nlm.nih.gov/21931276
https://pubmed.ncbi.nlm.nih.gov/21931276
Autor:
Mercè de Frias, Joan Gil, Antonio F. Santidrian, Ana M. Cosialls, Benoit Viollet, Eva González-Barca, Llorenç Coll-Mulet, Diana M. González-Gironès, Verena Labi, Daniel Iglesias-Serret, Gabriel Pons, Clara Campàs, Andreas Villunger, Esther Alonso, Adalberto Benito
Publikováno v:
Blood. 116(16)
5-Aminoimidazole-4-carboxamide riboside or acadesine (AICAR) induces apoptosis in chronic lymphocytic leukemia (CLL) cells. A clinical study of AICAR is currently being performed in patients with this disease. Here, we have analyzed the mechanisms in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32aeba92932456e09eb8e5b6af667fd0
https://pubmed.ncbi.nlm.nih.gov/20664053
https://pubmed.ncbi.nlm.nih.gov/20664053