Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Mercè Canal"'
Autor:
Terence W O'Neill, Neil Pendleton, Antony Payton, Asri Maharani, Altug Didikoglu, Maria Mercè Canal
Publikováno v:
BMJ Open, Vol 13, Iss 3 (2023)
Objectives Exposures in utero and during infancy may impact the development of diseases later in life. They may be linked with development of frailty, although the mechanism is unclear. This study aims to determine the associations between early life
Externí odkaz:
https://doaj.org/article/e298a4dddaa14dd28c78ebddd609ac9b
Autor:
Asri Maharani, Altug Didikoglu, Terence W O'Neill, Neil Pendleton, Maria Mercè Canal, Antony Payton
Publikováno v:
Maharani, A, Didikoglu, A, O'Neill, T, Pendleton, N, Canal Corretger, M M & Payton, A 2023, ' Education mediating the associations between early life factors and frailty: a cross-sectional study of the UK Biobank ', BMJ Open, vol. 13, no. 3, e057511 . https://doi.org/10.1136/bmjopen-2021-057511
ObjectivesExposures in utero and during infancy may impact the development of diseases later in life. They may be linked with development of frailty, although the mechanism is unclear. This study aims to determine the associations between early life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0883994a9a6f576edf2cb57c03fe60e
https://doi.org/10.1136/bmjopen-2021-057511
https://doi.org/10.1136/bmjopen-2021-057511
Autor:
Altug Didikoglu, Benjamin Walker, Asri Maharani, Neil Pendleton, Maria Mercè Canal, Antony Payton, Jon Gibson, Timothy Brown
Publikováno v:
Didikoglu, A, Walker, B, Maharani, A, Pendleton, N, Canal, M M, Payton, A, Gibson, J & Brown, T 2022, ' Associations between chronotype and employment status in a longitudinal study of an elderly population ', Chronobiology International, vol. 39, no. 8, pp. 1118-1131 . https://doi.org/10.1080/07420528.2022.2071158
Individuals with an 'evening' chronotype tend to sleep and wake later than people described to be 'morning' type if given a free choice. Since early awakening times, due to school and occupation, may be more challenging for those with evening chronot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7471d34fcc2bb3a08cb44880e1b3494b
https://research.manchester.ac.uk/en/publications/7a4ebb5e-02f8-4bf9-acb7-cc07142b87cb
https://research.manchester.ac.uk/en/publications/7a4ebb5e-02f8-4bf9-acb7-cc07142b87cb
Publikováno v:
Age and Ageing. 50:i12-i42
Introduction In elderly populations, sleep quality deteriorates and sleep time shifts towards earlier times. These sleep characteristics have been associated with cardiovascular, metabolic and psychiatric disorders, cognitive decline and mortality. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0436b0f5891785000a4d62de1e2d26b
https://doi.org/10.1093/ageing/afab030.10
https://doi.org/10.1093/ageing/afab030.10
Autor:
Antony Payton, Nisha Nair, Altug Didikoglu, Neil Pendleton, Maria Mercè Canal, Andrew C Robinson, Federico Roncaroli
Publikováno v:
Didikoglu, A, Nair, N, Robinson, A C, Roncaroli, F, Pendleton, N, Payton, A & Canal, M M 2021, ' The effect of season of birth on brain epigenome-wide DNA methylation of older adults ', Journal of Developmental Origins of Health and Disease, pp. 1-11 . https://doi.org/10.1017/S2040174421000453
Perinatal light exposure predisposes towards health and behaviour in adulthood. Season of birth is associated with psychiatric, allergic, cardiovascular and metabolic problems. It has been proposed that early-life environmental light disrupts the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47394dc28e35da59ae1dbf9a9fbc9e4
https://pubmed.ncbi.nlm.nih.gov/34308828
https://pubmed.ncbi.nlm.nih.gov/34308828
Autor:
Frédéric M. Vaz, Kia J. Langford-Smith, Claire O'Leary, Stewart Rust, Karen Tylee, Maria Mercè Canal, Arunabha Ghosh, Frits A. Wijburg, Simon Jones, Andy Vail, Brian W. Bigger, Helen Parker, Michelle Hepburn, Daniel Weisberg, Catherine Breen, J. Ed Wraith
Publikováno v:
Ghosh, A, Rust, S, Langford-Smith, K, Weisberg, D, Canal, M, Breen, C, Hepburn, M, Tylee, K, Vaz, F M, Vail, A, Wijburg, F, O'Leary, C, Parker, H, Wraith, E, Bigger, B W & Jones, S A 2021, ' High dose genistein in Sanfilippo syndrome : a randomised controlled trial ', Journal of Inherited Metabolic Disease . https://doi.org/10.1002/jimd.12407
Journal of inherited metabolic disease, 44(5), 1248-1262. Springer Netherlands
Journal of inherited metabolic disease, 44(5), 1248-1262. Springer Netherlands
The aim of this study was to evaluate the efficacy of high dose genistein aglycone in Sanfilippo syndrome (mucopolysaccharidosis type III). High doses of genistein aglycone have been shown to correct neuropathology and hyperactive behaviour in mice,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0a0d45660f2650ae6248545f665d9a0
https://www.research.manchester.ac.uk/portal/en/publications/high-dose-genistein-in-sanfilippo-syndrome(03230acd-691f-45e2-8555-54aa6956085b).html
https://www.research.manchester.ac.uk/portal/en/publications/high-dose-genistein-in-sanfilippo-syndrome(03230acd-691f-45e2-8555-54aa6956085b).html
Autor:
G Campoy, Xavier Gasull, Elena Feinstein, Joan Romaní-Aumedes, David L. Williamson, Leticia Pérez-Sisqués, Núria Martín-Flores, J Solana, Sara Fernández-García, H-Y Man, Manuel J. Rodriguez, Esther García-García, Artur Llobet, Mercè Masana, Jordi Alberch, Mercè Canal, JP Gilbert, Nuria Sánchez-Fernández, David Soto, Cristina Malagelada
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Background RTP801/REDD1 is a stress-regulated protein whose upregulation is necessary and sufficient to trigger neuronal death in in vitro and in vivo models of Parkinson's and Huntington's diseases and is up regulated in compromised neurons in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8b735542b9f3d11f5a5b7c7adb12480
http://hdl.handle.net/2445/177519
http://hdl.handle.net/2445/177519
Publikováno v:
Early Human Development
Didikoglu, A, Maharani, A, Pendleton, N, Canal, M & Payton, A 2021, ' Early life factors and COVID-19 infection in England: A prospective analysis of UK Biobank participants ', Early Human Development, vol. 155, 105326 . https://doi.org/10.1016/j.earlhumdev.2021.105326
Didikoglu, A, Maharani, A, Pendleton, N, Canal, M & Payton, A 2021, ' Early life factors and COVID-19 infection in England: A prospective analysis of UK Biobank participants ', Early Human Development, vol. 155, 105326 . https://doi.org/10.1016/j.earlhumdev.2021.105326
This study aims to examine whether maternal smoking, birth weight, birth month and breastfeeding are associated with COVID-19 infection and hospitalisation. Maternal smoking was positively associated with COVID-19 infection. Breastfeeding was negativ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89779ad4feda02a9a4ec0542102ebbd
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97160 (2014)
Early life programming has important consequences for future health and wellbeing. A key new aspect is the impact of perinatal light on the circadian system. Postnatal light environment will program circadian behavior, together with cell morphology a
Externí odkaz:
https://doaj.org/article/eec4dcf24086429fb254fc07ada97109
Autor:
Andrew C Robinson, Antony Payton, Maria Mercè Canal, Steven Bradburn, Chris Murgatroyd, Neil Pendleton, Altug Didikoglu, Bethany Hulme
Publikováno v:
Hulme, B, Didikoglu, A, Bradburn, S, Robinson, A, Canal, M, Payton, A, Pendleton, N & Murgatroyd, C 2020, ' Epigenetic regulation of BMAL1 with sleep disturbances and Alzheimer’s Disease ', Journal of Alzheimer's Disease . https://doi.org/10.3233/JAD-200634
Background:An early symptom of Alzheimer’s disease (AD) is a disturbance of the circadian rhythm that is associated with disrupted sleep/wake cycles.Objective:To investigate if BMAL1, a key gene that drives the circadian cycle, is epigenetically re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2d2a920dd74ce91cf14d067bbc9d43
https://e-space.mmu.ac.uk/626514/
https://e-space.mmu.ac.uk/626514/