Safety, tolerability, and immunogenicity of the novel antituberculous vaccine RUTI: randomized, placebo-controlled phase II clinical trial in patients with latent tuberculosis infection.

Autor: Andre S Nell, Eva D'lom, Patrick Bouic, Montserrat Sabaté, Ramon Bosser, Jordi Picas, Mercè Amat, Gavin Churchyard, Pere-Joan Cardona

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89612 (2014)

To evaluate the safety, tolerability and immunogenicity of three different doses (5, 25 and 50 µg) of the novel antituberculous vaccine RUTI compared to placebo in subjects with latent tuberculosis infection.Double-blind, randomized, placebo-control

Externí odkaz: https://doaj.org/article/80e8b01b80824ba6942419e1240dd216

Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors

Autor: Raquel F. Reinoso, Graham Warrellow, Elena Calaf, Francisco Caturla, Mercè Amat

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 16:3605-3608

The preparation of the sulfoxide analogues 7, 8, and 9 and their enantiomerically pure forms is discussed as well as their ability to act as prodrugs of the potent and selective sulfone-containing COX-2 inhibitors 1, 2, and 3. Sulfoxide derivatives 7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b876e6fbb26321f1b86a8f3fc2c379a
https://doi.org/10.1016/j.bmcl.2006.03.101

Ontogeny of L-Alanine Uptake in Plasma Membrane Vesicles from Rat Liver

Autor: Mercè Amat, Antonio Felipe, J Casado, Marçal Pastor-Anglada

Publikováno v: PEDIATRIC RESEARCH
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Alanine uptake into liver plasma membrane vesicles was studied at different stages of postnatal rat development. Before weaning, alanine hepatic uptake showed lower values for the global KM than after weaning (0.34, 0.77, 1.45, and 1.61 mM for 1-, 15

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3efda6519a1205442c3412b3c3fe6b
https://doi.org/10.1203/00006450-199507000-00014

Evolution of leukotriene B4, peptide leukotrienes, and interleukin-8 plasma concentrations in patients at risk of acute respiratory distress syndrome and with acute respiratory distress syndrome: mortality prognostic study

Autor: Artur Oliver, Jordi Fontcuberta, Juan-Francisco Mayoral, Miquel Barcons, Mercè Amat, Jordi Mancebo, José Mateo, Luis M. Vilá

Publikováno v: Critical care medicine. 28(1)

To compare the evolution of plasma concentrations of leukotriene (LT) B4, LTC4, LTD4, and interleukin (IL)-8 in patients with acute respiratory distress syndrome (ARDS) and in patients at risk of ARDS and to assess the value of these mediators in pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e557ccd4c70dd04b52043f3a40f484ef
https://pubmed.ncbi.nlm.nih.gov/10667541

RUTI Vaccination Enhances Inhibition of Mycobacterial Growth ex vivo and Induces a Shift of Monocyte Phenotype in Mice

Autor: Satria A. Prabowo, Hannah Painter, Andrea Zelmer, Steven G. Smith, Karin Seifert, Merce Amat, Pere-Joan Cardona, Helen A. Fletcher

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Tuberculosis (TB) is a major global health problem and there is a dire need for an improved treatment. A strategy to combine vaccination with drug treatment, termed therapeutic vaccination, is expected to provide benefit in shortening treatment durat

Externí odkaz: https://doaj.org/article/d1b8f6ee23b645918e6826ead877968d