Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Merav Socolovsky"'
Autor:
Daniel Hidalgo, Jacob Bejder, Ramona Pop, Kyle Gellatly, Yung Hwang, S. Maxwell Scalf, Anna E. Eastman, Jane-Jane Chen, Lihua Julie Zhu, Jules A. A. C. Heuberger, Shangqin Guo, Mark J. Koury, Nikolai Baastrup Nordsborg, Merav Socolovsky
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Maturing erythroblasts become smaller with every cell division. Here, the authors show that Epo stimulation promotes cell division and also generates larger red cells, and that this occurs in mouse and human cells, suggesting that red cell size could
Externí odkaz:
https://doaj.org/article/031bd812e42f4178b615be902c463c86
Autor:
A. Marieke Oudelaar, Robert A. Beagrie, Matthew Gosden, Sara de Ornellas, Emily Georgiades, Jon Kerry, Daniel Hidalgo, Joana Carrelha, Arun Shivalingam, Afaf H. El-Sagheer, Jelena M. Telenius, Tom Brown, Veronica J. Buckle, Merav Socolovsky, Douglas R. Higgs, Jim R. Hughes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The relationship between regulatory elements, chromatin interactions and gene expression during development remains poorly understood. Here the authors present Tiled-C, a low-input 3C approach to study genome architecture at high resolution, and appl
Externí odkaz:
https://doaj.org/article/a68d72c62d2d48089c3be17071099d2e
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 1 (2020)
Translating basic research to the clinic is a primary aim of Disease Models & Mechanisms, and the recent successes in hematopoiesis research provide a blueprint of how fundamental biological research can provide solutions to important clinical proble
Externí odkaz:
https://doaj.org/article/f59968b3be8d4317a4d685a38432e15f
Publikováno v:
PLoS Biology, Vol 10, Iss 8, p e1001383 (2012)
Erythropoietin (Epo)-induced Stat5 phosphorylation (p-Stat5) is essential for both basal erythropoiesis and for its acceleration during hypoxic stress. A key challenge lies in understanding how Stat5 signaling elicits distinct functions during basal
Externí odkaz:
https://doaj.org/article/1bfa8f29ca214760b8db113a4197eef1
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21192 (2011)
Erythropoiesis maintains a stable hematocrit and tissue oxygenation in the basal state, while mounting a stress response that accelerates red cell production in anemia, blood loss or high altitude. Thus, tissue hypoxia increases secretion of the horm
Externí odkaz:
https://doaj.org/article/2d1e88dd443f4927bf52770e7d30e2f2
Autor:
Ramona Pop, Jeffrey R Shearstone, Qichang Shen, Ying Liu, Kelly Hallstrom, Miroslav Koulnis, Joost Gribnau, Merav Socolovsky
Publikováno v:
PLoS Biology, Vol 8, Iss 9, p e1000484 (2010)
Hematopoietic progenitors undergo differentiation while navigating several cell division cycles, but it is unknown whether these two processes are coupled. We addressed this question by studying erythropoiesis in mouse fetal liver in vivo. We found t
Externí odkaz:
https://doaj.org/article/f5f582392f494394a3dadacd82bd92dd
Autor:
Merav Socolovsky, Michael Murrell, Ying Liu, Ramona Pop, Ermelinda Porpiglia, Andre Levchenko
Publikováno v:
PLoS Biology, Vol 5, Iss 10, p e252 (2007)
Tissue development is regulated by signaling networks that control developmental rate and determine ultimate tissue mass. Here we present a novel computational algorithm used to identify regulatory feedback and feedforward interactions between progen
Externí odkaz:
https://doaj.org/article/e16353b3e567477584809f74186d4946
Autor:
Merav Socolovsky
Publikováno v:
International Journal of Hematology. 116:163-173
Early erythroid progenitors known as CFU-e undergo multiple self-renewal cell cycles. The CFU-e developmental stage ends with the onset of erythroid terminal differentiation (ETD). The transition from CFU-e to ETD is a critical cell fate decision tha
Autor:
Christine Vogel, Gábor Balázsi, Alexander Löwer, Caifu Jiang, Amy K. Schmid, Morten Sommer, Laurence Yang, Christian Münch, Andrew Wang, Kavita Israni-Winger, Timo Mühlhaus, David L. Des Marais, Henrik Oster, Merav Socolovsky
Publikováno v:
Cell Systems. 13:195-200
Publikováno v:
Journal of visualized experiments : JoVE. (189)
Early erythroid progenitors were originally defined by their colony-forming potential in vitro and classified into burst-forming and colony-forming "units" known as BFU-e and CFU-e. Until recently, methods for the direct prospective and complete isol