Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Merav Fichman"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141061 (2015)
CYP3A4 is recognized as the main enzyme involved in the metabolism of drugs and xenobiotics in the human body and its inhibition may lead to undesirable consequences. Stilbenes, including resveratrol, belong to a group of dietary health-promoting com
Externí odkaz:
https://doaj.org/article/ac4e3561463a4afa89c687f0c51957e6
Publikováno v:
Applied Clay Science. :241-247
The adsorption of organic pollutants to a novel adsorbent–polyvinyl-pyridine- co -styrene–montmorillonite nanocomposite was quantified and modeled. To elucidate the adsorption mechanisms, experimental methods and QSAR analysis were combined, sear
Autor:
Kevin Ryan, Min Ting Liu, Zita Peterlin, Hiroaki Matsunami, Stuart Firestein, Jianghai Ho, Merav Fichman, Tali Yarnitzky, Masha Y. Niv, Yadi Li
Publikováno v:
ACS Chemical Biology
The mammalian odorant receptors (ORs) form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niche
Autor:
Yael Marantz, Alexander Heifetz, Dora Warshaviak, Silvia Noiman, Boaz Inbal, Maya Topf, Merav Fichman, Oren M. Becker, Zvi Naor, Noa Avisar, Sharon Shacham, Ori Kalid, Shay Bar-Haim
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 57:51-86
G-protein coupled receptors (GPCRs) are a major group of drug targets for which only one x-ray structure is known (the nondrugable rhodopsin), limiting the application of structure-based drug discovery to GPCRs. In this paper we present the details o
Publikováno v:
Applied and environmental microbiology. 78(22)
We previously found that a short exposure of Staphylococcus aureus to subinhibitory (SI) doses of epigallocatechin gallate (EGCG) results in increased cell wall thickness, adaptation, and enhanced tolerance to cell-wall-targeted antibiotics. In this
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0141061 (2015)
PLoS ONE, Vol 10, Iss 10, p e0141061 (2015)
CYP3A4 is recognized as the main enzyme involved in the metabolism of drugs and xenobiotics in the human body and its inhibition may lead to undesirable consequences. Stilbenes, including resveratrol, belong to a group of dietary health-promoting com
Autor:
Yael Marantz, I. Sela, Y. Markus, M. Strajbl, G. Golan, Ori Kalid, Alina Shitrit, I. Bloch, B. Inbal, Hanoch Senderowitz, Efrat Ben-Zeev, D. Rivenzon-Segal, Merav Fichman, Shay Bar-Haim
Publikováno v:
Current topics in medicinal chemistry. 10(6)
In silico drug discovery is a complex process requiring flexibility and ingenuity in method selection and a careful validation of work protocols. GPCR in silico drug discovery poses additional challenges due to the paucity of crystallographic data. T
Autor:
Oren M. Becker, Merav Fichman, Alexander Heifetz, Chen Dongli, Michael Kauffman, Dhanoa Dale S, Yael Marantz, Srinivasa Rao Cheruku, Sharon Shacham, Raphael Nudelman, Silvia Noiman, Anurag Sharadendu, Pradyumna Mohanty
Publikováno v:
Journal of medicinal chemistry. 49(11)
We report the discovery of a novel, potent, and selective amidosulfonamide nonazapirone 5-HT1A agonist for the treatment of anxiety and depression, which is now in Phase III clinical trials for generalized anxiety disorder (GAD). The discovery of 20m
Autor:
Merav Fichman, Oren M. Becker, Sharon Shacham, Dora Warshaviak, Shay Bar-Haim, Silvia Noiman, Boaz Inbal, Ori Kalid, Alexander Heifetz, Yael Marantz
The application of structure-based in silico methods to drug discovery is still considered a major challenge, especially when the x-ray structure of the target protein is unknown. Such is the case with human G protein-coupled receptors (GPCRs), one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d507cf343de0fe9320a4ed5905da87dd
https://europepmc.org/articles/PMC509175/
https://europepmc.org/articles/PMC509175/