Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Merav D Shmueli"'
Autor:
Ron Benyair, Sai Srinivas Panapakkam Giridharan, Pilar Rivero-Ríos, Junya Hasegawa, Emily Bristow, Eeva-Liisa Eskelinen, Merav D Shmueli, Vered Fishbain-Yoskovitz, Yifat Merbl, Lisa M Sharkey, Henry L. Paulson, Phyllis I Hanson, Samarjit Patnaik, Ismael Al-Ramahi, Juan Botas, Juan Marugan, Lois S. Weisman
Publikováno v:
Autophagy Reports, Vol 2, Iss 1 (2023)
Many neurodegenerative diseases, including Huntington’s disease (HD) and Alzheimer’s disease (AD), occur due to an accumulation of aggregation-prone proteins, which results in neuronal death. Studies in animal and cell models show that reducing t
Externí odkaz:
https://doaj.org/article/025cf5e3def14b5b85e8e1ea105c7f8c
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109864 (2014)
The von Hippel-Lindau (VHL) cancer syndrome is associated with mutations in the VHL gene. The pVHL protein is involved in response to changes in oxygen availability as part of an E3-ligase that targets the Hypoxia-Inducible Factor for degradation. pV
Externí odkaz:
https://doaj.org/article/cb535ab30b754af6acfaa31c0bd580bb
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66333 (2013)
Loss of function mutations in the von Hippel-Lindau (pVHL) tumor suppressor protein are tumorigenic. In silico analysis of the structure and folding of WT pVHL identified in its core an aromatic tetrahedron, essential for stabilizing the protein. The
Externí odkaz:
https://doaj.org/article/bd8abed363e5477ab7446ecf974ee645
Autor:
Aaron Javitt, Merav D. Shmueli, Matthias P. Kramer, Aleksandra A. Kolodziejczyk, Ivan J. Cohen, Lihi Radomir, Daoud Sheban, Iris Kamer, Kevin Litchfield, Elizabeta Bab-Dinitz, Oranit Zadok, Vanessa Neiens, Adi Ulman, Hila Wolf-Levy, Avital Eisenberg-Lerner, Assaf Kacen, Michal Alon, Ana Toste Rêgo, Elvira Stacher-Priehse, Michael Lindner, Ina Koch, Jair Bar, Charles Swanton, Yardena Samuels, Yishai Levin, Paula C. A. da Fonseca, Eran Elinav, Nir Friedman, Silke Meiners, Yifat Merbl
Publikováno v:
Nature Cancer. 4:629-647
Autor:
Danping Zheng, Gayatree Mohapatra, Lara Kern, Yiming He, Merav D. Shmueli, Rafael Valdés-Mas, Aleksandra A. Kolodziejczyk, Tomasz Próchnicki, Matilde B. Vasconcelos, Lena Schorr, Franziska Hertel, Ye Seul Lee, Miguel Camacho Rufino, Emmanuelle Ceddaha, Sandy Shimshy, Ryan James Hodgetts, Mally Dori-Bachash, Christian Kleimeyer, Kim Goldenberg, Melina Heinemann, Noa Stettner, Alon Harmelin, Hagit Shapiro, Jens Puschhof, Minhu Chen, Richard A. Flavell, Eicke Latz, Yifat Merbl, Suhaib K. Abdeen, Eran Elinav
Publikováno v:
Nature Immunology. 24:585-594
Autor:
Assaf Kacen, Aaron Javitt, Matthias P. Kramer, David Morgenstern, Tomer Tsaban, Merav D. Shmueli, Guo Ci Teo, Felipe da Veiga Leprevost, Eilon Barnea, Fengchao Yu, Arie Admon, Lea Eisenbach, Yardena Samuels, Ora Schueler-Furman, Yishai Levin, Alexey I. Nesvizhskii, Yifat Merbl
Publikováno v:
Nature Biotechnology. 41:239-251
Post-translational modification (PTM) of antigens provides an additional source of specificities targeted by immune responses to tumors or pathogens, but identifying antigen PTMs and assessing their role in shaping the immunopeptidome is challenging.
Autor:
Ronen Levy, Tal Alter Regev, Wayne Paes, Nofar Gumpert, Sapir Cohen Shvefel, Osnat Bartok, Maria Dayan-Rubinov, Michal Alon, Merav D. Shmueli, Yishai Levin, Yifat Merbl, Nicola Ternette, Yardena Samuels
Publikováno v:
Mol Cell Proteomics
Posttranslational spliced peptides (PTSPs) are a unique class of peptides that have been found to be presented by HLA class-I molecules in cancer. Thus far, no consensus has been reached on the proportion of PTSPs in the immunopeptidome, with estimat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be4d61799b3cbba8e4cb19a32a9347e
https://europepmc.org/articles/PMC10119686/
https://europepmc.org/articles/PMC10119686/
Publikováno v:
The FEBS Journal
Histones constitute the primary protein building blocks of the chromatin and play key roles in the dynamic control of chromatin compaction and epigenetic regulation. Histones are regulated by intricate mechanisms that alter their functionality and st
Autor:
Daoud Sheban, Tom Shani, Roey Maor, Alejandro Aguilera-Castrejon, Nofar Mor, Bernardo Oldak, Merav D. Shmueli, Avital Eisenberg-Lerner, Jonathan Bayerl, Jakob Hebert, Sergey Viukov, Guoyun Chen, Assaf Kacen, Vladislav Krupalnik, Valeriya Chugaeva, Shadi Tarazi, Alejandra Rodríguez-delaRosa, Mirie Zerbib, Adi Ulman, Solaiman Masarwi, Meital Kupervaser, Yishai Levin, Efrat Shema, Yael David, Noa Novershtern, Jacob H. Hanna, Yifat Merbl
Publikováno v:
Molecular Cell
The fidelity of the early embryonic program is underlined by tight regulation of the chromatin. Yet, how the chromatin is organized to prohibit the reversal of the developmental program remains unclear. Specifically, the totipotency-to-pluripotency t
Autor:
Rohit Kumar, Julia Herber, Peter Jedlicka, Jakob Klotz, Jasenka Rudan Njavro, Bastian Dislich, Peer-Hendrik Kuhn, Regina Feederle, Stephan A. Müller, Marcus Conrad, Andreas Vlachos, Stylianos Michalakis, Stefan F. Lichtenthaler, Johanna Wanngren, Wolfgang Wurst, Thomas Koeglsperger, Merav D. Shmueli
Publikováno v:
Rudan Njavro, Jasenka; Klotz, Jakob; Dislich, Bastian; Wanngren, Johanna; Shmueli, Merav D; Herber, Julia; Kuhn, Peer-Hendrik; Kumar, Rohit; Koeglsperger, Thomas; Conrad, Marcus; Wurst, Wolfgang; Feederle, Regina; Vlachos, Andreas; Michalakis, Stylianos; Jedlicka, Peter; Müller, Stephan A; Lichtenthaler, Stefan F (2020). Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1. FASEB journal, 34(2), pp. 2465-2482. Federation of American Societies for Experimental Biology 10.1096/fj.201902347R
The FASEB journal 34(2), 2465-2482 (2020). doi:10.1096/fj.201902347R
The FASEB journal 34(2), 2465-2482 (2020). doi:10.1096/fj.201902347R
The protease beta-site APP cleaving enzyme 1 (BACE1) has fundamental functions in the nervous system. Its inhibition is a major therapeutic approach in Alzheimer's disease, because BACE1 cleaves the amyloid precursor protein (APP), thereby catalyzing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c80633f97dde48d1236523da32d643