Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Meral Tuncbilek"'
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 23:585-598
Background: Cancer cells restrain apoptotic and senescence pathways through intracellular heat shock protein 70 (Hsp 70). These cells aid stimulus-independent growth, and their higher metabolism rate requires Hsps. Hsps compensate abnormally increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca0faaaba3e1c94d7207608dc4babf0
https://doi.org/10.2174/1871520622666220905122346
https://doi.org/10.2174/1871520622666220905122346
Publikováno v:
Acta Chimica Slovenica, Vol 64, Iss 3, Pp 621-632 (2017)
A series of 6-(4-substituted phenyl)-9-(tetrahydropyran-2-yl)purines 3–9, 6-(4-substituted phenyl)purines 10–16, 9-((4-substituted phenyl)sulfonyl)-6-(4-substituted phenyl)purines 17–32 were prepared and screened initially for their in vitro an
Externí odkaz:
https://doaj.org/article/b51e5510129644baa97c0a1714b060aa
Autor:
Meral Tuncbilek, Hind M Osman
Publikováno v:
Current medicinal chemistry. 29(15)
Background: Entrectinib is a highly potent ATP-competitive and selective inhibitor of tyrosine kinases - Trk A B C, ALK, and ROS1. It was developed by Roche and initially approved in Japan in 2019 to treat pediatric and adult patients with NTRK fusio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ed7059596c4fddba704818a02f824a
https://pubmed.ncbi.nlm.nih.gov/34521321
https://pubmed.ncbi.nlm.nih.gov/34521321
Autor:
Meral Tuncbilek, M. Fatih Polat
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 40(3)
Antimetabolites, which are metabolic antagonists used in the treatment of cancer and viral diseases by replacing metabolites, inhibit the action of metabolic enzymes and disrupt the pathways of synthesis of structural units necessary for the formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7644b12271295971e7eae176bd3f8d
https://pubmed.ncbi.nlm.nih.gov/33416028
https://pubmed.ncbi.nlm.nih.gov/33416028
Publikováno v:
Acta Chimica Slovenica, Vol 67, Iss 1, Pp 70-82 (2020)
A series of new 6,9-disubstituted purine analogs with 4-substituted piperazine at C-6 and 4-substituted benzyl at N-9 were designed and synthesized in four steps. All synthesized compounds (7-26) were screened initially for their in vitro anticancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22a3173620be8ddddcac4e90cb40d4b
https://aperta.ulakbim.gov.tr/record/5573
https://aperta.ulakbim.gov.tr/record/5573
Autor:
Zeynep Demir, Meral Tuncbilek, Rengul Cetin Atalay, Ebru Bilget Guven, Canan Kazak, Süheyla Özbey
Publikováno v:
European Journal of Medicinal Chemistry
Kazak, Canan/0000-0003-2475-8775; Guven, Ebru Bilget/0000-0001-9734-9679; Cetin-Atalay, Rengul/0000-0003-2408-6606 WOS: 000348003500058 PubMed: 25462277 Novel 9-(substituted amino/piperazinoethyl)adenines (4-12), 6-(substituted piperazino/amino)purin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dfb6c873d9d35f0900ce31b294b4c67
https://doi.org/10.1016/j.ejmech.2014.10.080
https://doi.org/10.1016/j.ejmech.2014.10.080
Autor:
Duygu Altiparmak, Ebru Bilget Guven, Meral Tuncbilek, Rengul Cetin-Atalay, Asligul Kucukdumlu
Publikováno v:
Bioorganic and Medicinal Chemistry Letters
New nucleoside derivatives with nitrogen substitution at the C-6 position were prepared and screened initially for their in vitro anticancer bioactivity against human epithelial cancer cells (liver Huh7, colon HCT116, breast MCF7) by the NCI-sulforho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffe596fa66a16f4357ad13abaab7351
https://pubmed.ncbi.nlm.nih.gov/29326016
https://pubmed.ncbi.nlm.nih.gov/29326016
Publikováno v:
Acta Chimica Slovenica
Acta Chimica Slovenica, Vol 64, Iss 3, Pp 621-632 (2017)
Acta Chimica Slovenica, Vol 64, Iss 3, Pp 621-632 (2017)
A series of 6-(4-substituted phenyl)-9-(tetrahydropyran-2-yl)purines 3 – 9 , 6-(4-substituted phenyl)purines 10 – 16 , 9-((4-substituted phenyl)sulfonyl)-6-(4-substituted phenyl)purines 17 – 32 were prepared and screened initially for their in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1b2a9bf0f1dfbf4c95240857cbe3842
https://hdl.handle.net/11693/37007
https://hdl.handle.net/11693/37007
Autor:
Canan Kus, Gulgun Ayhan-Kylcygila, Meral Tuncbilek, Nurten Altanlar, Tulay Coban, Benay Can-Eke, Mumtaz Iscan
Publikováno v:
Letters in Drug Design & Discovery. 6:374-379
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a57ba6e96cfdc48cd835b23956e944
https://doi.org/10.2174/1570180810906050374
https://doi.org/10.2174/1570180810906050374
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1693-1700
A series of 8,9-disubstituted adenines (4, 5, 8), 6-substituted aminopurines (10-13) and 9-(p-fluorobenzyl/cyclopentyl)-6-substituted aminopurines (16, 17, 19-30) have been prepared and the antimicrobial activities of these compounds against Staphylo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b9f66101fada1c6f1fc62960d6904a
https://doi.org/10.1016/j.bmc.2008.12.050
https://doi.org/10.1016/j.bmc.2008.12.050