Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

Autor: Lars Binkle-Ladisch, Andy Pironet, Andrea Zaliani, Chantal Alcouffe, Daniel Mensching, Undine Haferkamp, Anne Willing, Marcel S. Woo, Alexandre Erdmann, Timm Jessen, Stephen D. Hess, Philip Gribbon, Ole Pless, Rudi Vennekens, Manuel A. Friese

Publikováno v: iScience, Vol 27, Iss 12, Pp 111425- (2024)

Summary: Neurodegeneration in central nervous system disorders is linked to dysregulated neuronal calcium. Direct inhibition of glutamate-induced neuronal calcium influx, particularly via N-methyl-D-aspartate receptors (NMDAR), has led to adverse eff

Externí odkaz: https://doaj.org/article/7c4743fbba874384a913ff92e62451a3

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

Autor: Binkle-Ladisch, Lars, Pironet, Andy, Zaliani, Andrea, Alcouffe, Chantal, Mensching, Daniel, Haferkamp, Undine, Willing, Anne, Woo, Marcel S., Erdmann, Alexandre, Jessen, Timm, Hess, Stephen D., Gribbon, Philip, Pless, Ole, Vennekens, Rudi, Friese, Manuel A.

Publikováno v: In iScience 20 December 2024 27(12)

Prediction of key milk biomarkers in dairy cows through milk mid-infrared spectra and international collaborations

Autor: C. Grelet, T. Larsen, M.A. Crowe, D.C. Wathes, C.P. Ferris, K.L. Ingvartsen, C. Marchitelli, F. Becker, A. Vanlierde, J. Leblois, U. Schuler, F.J. Auer, A. Köck, L. Dale, J. Sölkner, O. Christophe, J. Hummel, A. Mensching, J.A. Fernández Pierna, H. Soyeurt, M. Calmels, R. Reding, M. Gelé, Y. Chen, N. Gengler, F. Dehareng

Publikováno v: Journal of Dairy Science, Vol 107, Iss 3, Pp 1669-1684 (2024)

ABSTRACT: At the individual cow level, suboptimum fertility, mastitis, negative energy balance, and ketosis are major issues in dairy farming. These problems are widespread on dairy farms and have an important economic impact. The objectives of this

Externí odkaz: https://doaj.org/article/ce689e1d98a64dbd945ccb7366c5b436

Proposed automated contrast-enhanced microscopical method for evaluating air void structure in compacted asphalt concrete mixtures

Autor: Beyene, Mengesha, Elwardany, Michael, Youtcheff, Jack, Mensching, David, Myers, Leslie

Publikováno v: In Construction and Building Materials 15 March 2024 419

Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders

Autor: Abarca-Barriga, Hugo, Al-Haddad, Christiane, Berman, Jeffrey L., Bothun, Erick D., Capasso, Jenina, Chacon-Camacho, Oscar Francisco, Chang, Lan, Christiansen, Stephen P., Ciccarelli, Maria Laura, Cordonnier, Monique, Cox, Gerald F., Curry, Cynthia J., Dagi, Linda R., Lee Dahm, Thomas, David, Karen L., Davitt, Bradley V., De Berardinis, Teresa, Demer, Joseph L., Désir, Julie, D’Esposito, Fabiana, Drack, Arlene V., Eggenberger, Eric, Elder, James E., Elliott, Alexandra T., Epley, K. David, Feldman, Hagit Baris, Ferreira, Carlos R., Flaherty, Maree P., Fulton, Anne B., Gerth-Kahlert, Christina, Gottlob, Irene, Grill, Stephen, Halliday, Dorothy J., Hanisch, Frank, Hay, Eleanor, Heidary, Gena, Holder, Christopher, Horton, Jonathan C., Iannaccone, Alessandro, Isenberg, Sherwin J., Johnston, Suzanne C., Kahana, Alon, Katowitz, James A., Kazlas, Melanie, Kerr, Natalie C., Kimonis, Virginia, Ko, Melissa W., Koc, Feray, Larsen, Dorte Ancher, Lay-Son, Guillermo, Ledoux, Danielle M., Levin, Alex V., Levy, Richard L., Lyons, Christopher J., Mackey, David A., Magli, Adriano, Mantagos, Iason S., Marti, Candice, Maystadt, Isabelle, McKenzie, Fiona, Menezes, Manoj P., Mikail, Claudia N., Miller, David T., Miller, Kathryn Bisceglia, Mills, Monte D., Miyana, Kaori, Moller, H.U., Mullineaux, Lisa, Nishimura, Julie K., Noble, A. Gwendolyn, Pandey, Pramod Kumar, Pavone, Piero, Penzien, Johann, Petersen, Robert, Phalen, James A., Poduri, Annapurna, Polo, Claudia R., Prasov, Lev, Ramos, Feliciano J., Ramos-Caceres, Maria, Robb, Richard M., Rossillion, Béatrice, Sahin, Mustafa, Singer, Harvey S., Smith, Lois E.H., Sorkin, Jeffrey A., Soul, Janet S., Staffieri, Sandra E., Stalker, Heather J., Stasheff, Steven F., Strassberg, Sonya, Strominger, Mitchell B., Taranath, Deepa Ajay, Thomas, Ioan Talfryn, Traboulsi, Elias I., Ugrin, Maria Cristina, VanderVeen, Deborah K., Vincent, Andrea L., Vogel G, Marlene C., Wabbels, Bettina, Wong, Agnes M.F., Woods, C. Geoffrey, Wu, Carolyn, Yang, Edward, Yeung, Alison, Young, Terri L., Zenteno, Juan C., Zubcov-Iwantscheff, Alexandra A., Zwaan, Johan, Jurgens, Julie A., Barry, Brenda J., Chan, Wai-Man, MacKinnon, Sarah, Whitman, Mary C., Matos Ruiz, Paola M., Pratt, Brandon M., England, Eleina M., Pais, Lynn, Lemire, Gabrielle, Groopman, Emily, Glaze, Carmen, Russell, Kathryn A., Singer-Berk, Moriel, Di Gioia, Silvio Alessandro, Lee, Arthur S., Andrews, Caroline, Shaaban, Sherin, Wirth, Megan M., Bekele, Sarah, Toffoloni, Melissa, Bradford, Victoria R., Foster, Emma E., Berube, Lindsay, Rivera-Quiles, Cristina, Mensching, Fiona M., Sanchis-Juan, Alba, Fu, Jack M., Wong, Isaac, Zhao, Xuefang, Wilson, Michael W., Weisburd, Ben, Lek, Monkol, Brand, Harrison, Talkowski, Michael E., MacArthur, Daniel G., O’Donnell-Luria, Anne, Robson, Caroline D., Hunter, David G., Engle, Elizabeth C.

Publikováno v: In Genetics in Medicine July 2024