Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain

Autor: Ferrari F, Fiorentino S, Mennuni L, Garofalo P, Letari O, Mandelli S, Giordani A, Lanza M, Caselli G

Publikováno v: Journal of Pain Research, Vol 2011, Iss default, Pp 111-125 (2011)

Flora Ferrari1, Simonetta Fiorentino1, Laura Mennuni1, Paolo Garofalo1, Ornella Letari1, Stefano Mandelli2, Antonio Giordani3, Marco Lanza1, Gianfranco Caselli11Department of Pharmacology and Toxicology; 2Department of Medicinal Chemistry; 3R&D Chemi

Externí odkaz: https://doaj.org/article/17cfb86de8ad4b85afbf8e7a8e4c75ac

Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

Autor: Chiusaroli, R. ^†, Visentini, M. ^‡, Galimberti, C. ^†, Casseler, C. ^‡, Mennuni, L. ^†, Covaceuszach, S. ^‡, Lanza, M. ^†, Ugolini, G. ^‡, Caselli, G. ^†, Rovati, L.C. ^†, Visintin, M. ^‡

Publikováno v: In Osteoarthritis and Cartilage November 2013 21(11):1807-1810

Structure-affinity relationship studies on arylpiperazine derivatives related to quizapine as serotonin transporter ligands. Molecular basis of the selectivity SERT/5HT3 receptor

Autor: Cappelli A. 1, Giuliani G. 1, Gallelli A. 1, Valenti S. 1, Anzini M. 1, Mennuni L. 2, Makovec F. 2, Cupello A. 3, Vomero S. 1

Publikováno v: Bioorganic & medicinal chemistry
13 (2005): 3455–3460.
info:cnr-pdr/source/autori:Cappelli A. 1, Giuliani G. 1, Gallelli A. 1, Valenti S. 1, Anzini M. 1, Mennuni L. 2, Makovec F. 2, Cupello A. 3, Vomero S. 1/titolo:Structure-affinity relationship studies on arylpiperazine derivatives related to quizapine as serotonin transporter ligands. Molecular basis of the selectivity SERT%2F5HT3 receptor/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2005/pagina_da:3455/pagina_a:3460/intervallo_pagine:3455–3460/volume:13

A series of quipazine derivatives, previously synthesized to probe the 5-HT(3) receptor, was evaluated for its potential interaction with serotonin transporter (SERT). Some of them show nanomolar affinity for the rodent SERT comparable to or slightly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::cd2543961f8d38abd60b6f5f7cc61891
http://www.cnr.it/prodotto/i/10153

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