Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Menno van Lookeren Campagne"'
Autor:
Boyang Zhao, Zhongzheng Cao, Yi Zheng, Phuong Nguyen, Alisa Bowen, Robert H. Edwards, Robert M. Stroud, Yi Zhou, Menno Van Lookeren Campagne, Fei Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Heparan sulfate (HS) is degraded in lysosome by a series of glycosidases. Before the glycosidases can act, the terminal glucosamine of HS must be acetylated by the integral lysosomal membrane enzyme heparan-α-glucosaminide N-acetyltransfera
Externí odkaz:
https://doaj.org/article/091a56a11ba243ee9a6873110fec50cb
Autor:
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112298- (2023)
Externí odkaz:
https://doaj.org/article/50149307557045f491296fd14962a70c
Autor:
Elaine Mai, Joyce Chan, Levina Goon, Braeden K. Ego, Jack Bevers, Tiffany Wong, Manda Wong, Racquel Corpuz, Hongkang Xi, Jia Wu, Kellen Schneider, Dhaya Seshasayee, Michele Grimbaldeston, Gerald Nakamura, Vahan B. Indjeian, Menno van Lookeren Campagne, Kelly M. Loyet, Laetitia Comps-Agrar
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-15 (2021)
Abstract Background Over the past decade, human Interleukin 33 (hIL-33) has emerged as a key contributor to the pathogenesis of numerous inflammatory diseases. Despite the existence of several commercial hIL-33 assays spanning multiple platform techn
Externí odkaz:
https://doaj.org/article/bbbe6e02b17b49a79ce3aff20db379de
Autor:
Luz D. Orozco, Hsu-Hsin Chen, Christian Cox, Kenneth J. Katschke, Jr., Rommel Arceo, Carmina Espiritu, Patrick Caplazi, Sarajane Saturnio Nghiem, Ying-Jiun Chen, Zora Modrusan, Amy Dressen, Leonard D. Goldstein, Christine Clarke, Tushar Bhangale, Brian Yaspan, Marion Jeanne, Michael J. Townsend, Menno van Lookeren Campagne, Jason A. Hackney
Publikováno v:
Cell Reports, Vol 30, Iss 4, Pp 1246-1259.e6 (2020)
Summary: Age-related macular degeneration (AMD) is a leading cause of vision loss. To better understand disease pathogenesis and identify causal genes in GWAS loci for AMD risk, we present a comprehensive database of human retina and retinal pigment
Externí odkaz:
https://doaj.org/article/1d550e817e174a2695fd2849cb2c4767
Autor:
Junghyun Lim, Hyunjoo Park, Jason Heisler, Timurs Maculins, Merone Roose-Girma, Min Xu, Brent Mckenzie, Menno van Lookeren Campagne, Kim Newton, Aditya Murthy
Publikováno v:
eLife, Vol 8 (2019)
RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic interaction motif (RHIM) domains, are key components of inflammatory signaling and programmed cell death. RHIM-domain protein activation is mediated by their oligomeriza
Externí odkaz:
https://doaj.org/article/65547a6cbe0d4331a1d0842c177c9b54
Autor:
Amos Baruch, Kenneth J. Katschke, Victoria Pham, Shadi Toghi Eshghi, Phillip Lai, Andrew Ah Young, Wei-Ching Liang, Jennie R. Lill, Chingwei V. Lee, Wei Li, Menno Van Lookeren Campagne, Johnny Gutierrez, Daniel Kirchhofer, Isabel Figueroa, Scott J. Snipas, Guy S. Salvesen, Irene Tom, Lee Honigberg, Jitendra Kanodia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Genome-wide association studies have identified genetic variation at the ARMS2/HTRA1 locus as a risk factor for the development and progression of age-related macular degeneration (AMD). We have developed a potent anti-HtrA1 Fab inhibito
Autor:
Andrew P. AhYoung, Stefan Gerhardy, Menno van Lookeren Campagne, Daniel Kirchhofer, S. Jack Lin
Publikováno v:
Biochimie. 166:19-26
The recently discovered neutrophil serine protease 4 (NSP4) is the fourth member of the NSP family, which includes the well-studied neutrophil elastase, proteinase 3 and cathepsin G. Like the other three NSP members, NSP4 is synthesized by myeloid pr
Autor:
David L. Lin, Varun N. Kapoor, Naruhisa Ota, Joseph Chavarria-Smith, Christian Cox, Menno van Lookeren Campagne, Travis W. Bainbridge, Noelyn M. Kljavin, Keith R. Anderson, Joseph R. Arron, Frederic J. de Sauvage, Shannon J. Turley, Yun Li, Søren Warming, Elaine E. Storm, Lifen Wang, Merone Roose-Girma
Publikováno v:
Science Immunology. 6
Repair of the intestinal epithelium is tightly regulated to maintain homeostasis. The response after epithelial damage needs to be local and proportional to the insult. How different types of damage are coupled to repair remains incompletely understo
Autor:
Dawn Weishuhn, Simone Brioschi, Diana Cha, Marco Colonna, Daniel Yoo, Sara Rao, Samuel A. Hasson, Jodi Bradley, Peng Luan, Ian Foltz, Shilpa Sambashivan, Shoutang Wang, Daniel C. Ellwanger, Menno Van Lookeren Campagne, Susan Gilfillan, Palaniswami Rathanaswami, Ryan Case, Lydia Green, Zhifei Shao
Publikováno v:
Proc Natl Acad Sci U S A
Triggering receptor expressed on myeloid cells 2 (TREM2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (Aβ). Alzheimer’s disease (AD) risk is associated with the TREM2(R47H) variant, w
Autor:
Qui T. Phung, Stefan Gerhardy, Mike Reichelt, Michele A. Grimbaldeston, Lucinda W Tam, Patrick Caplazi, Alvin Gogineni, Andrew P. AhYoung, Christian Cox, Robby M. Weimer, Daniel Kirchhofer, Jason A. Hackney, Sterling C Eckard, Wyne P. Lee, Robert J. Newman, Merone Roose-Girma, Jennie R. Lill, Anand Kumar Katakam, Hongkang Xi, Juan Zhang, Aditya Murthy, S. Jack Lin, Paolo Manzanillo, Menno Van Lookeren Campagne
Publikováno v:
Communications Biology
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-13 (2020)
Vascular leakage, or edema, is a serious complication of acute allergic reactions. Vascular leakage is triggered by the release of histamine and serotonin from granules within tissue-resident mast cells. Here, we show that expression of Neutrophil Se