Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Menno T de Bruijn"'
Autor:
Winan J. van Houdt, Frederik J.H. Hoogwater, Menno T. de Bruijn, Benjamin L. Emmink, Maarten W. Nijkamp, Danielle A.E. Raats, Petra van der Groep, Paul van Diest, Inne H.M. Borel Rinkes, Onno Kranenburg
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 6, Pp 443-452 (2010)
Epidermal growth factor receptor (EGFR)-targeting therapeutics have shown efficacy in the treatment of colorectal cancer patients. Clinical studies have revealed that activating mutations in the KRAS protooncogene predict resistance to EGFR-targeted
Externí odkaz:
https://doaj.org/article/a17dd95799644a4085e7bad345f1f618
Oncogenic K-Ras Activates p38 to Maintain Colorectal Cancer Cell Proliferation during MEK Inhibition
Autor:
Winan J. van Houdt, Menno T. de Bruijn, Benjamin L. Emmink, Danielle Raats, Frederik J. H. Hoogwater, Inne H. M. Borel Rinkes, Onno Kranenburg
Publikováno v:
Cellular Oncology, Vol 32, Iss 4, Pp 245-257 (2010)
Background: Colon carcinomas frequently contain activating mutations in the K-ras proto-oncogene. K-ras itself is a poor drug target and drug development efforts have mostly focused on components of the classical Ras-activated MEK/ERK pathway. Here w
Externí odkaz:
https://doaj.org/article/4daa0ec8b6934c30a46edea6cf1b18a1
Autor:
Jan Wille, Daniel A. F. van den Heuvel, Jean-Paul P.M. de Vries, Erik Tournoij, Menno T de Bruijn, Debbie A B de Vries-Werson
Publikováno v:
Vascular. 24(4)
Purpose To describe an off-the-shelf method for the treatment of abdominal aortic aneurysms with hostile (large, >30 mm) neck and/or small (Case report We describe five patients with large aortic necks and/or small aortic bifurcations, which were tre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c0ab15e72d2b56db8071b0d28b5bf5
https://pubmed.ncbi.nlm.nih.gov/27235389
https://pubmed.ncbi.nlm.nih.gov/27235389
Publikováno v:
Journal of Vascular Surgery Cases
Acute buttock ischemia can be a consequence of aneurysmatic disease and has a dramatic presentation. This case report describes an otherwise healthy patient with a simultaneous onset of buttock ischemia combined with sciatic nerve compression caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc788df1bd24220e5b32abe7f5d53e12
https://lirias.kuleuven.be/handle/123456789/650034
https://lirias.kuleuven.be/handle/123456789/650034
Hypoxia after liver surgery imposes an aggressive cancer stem cell phenotype on residual tumor cells
Autor:
Klaas M. Govaert, Benjamin L. Emmink, Ernst J. A. Steller, Menno T. de Bruijn, Zing J. Cheung, Maarten W. Nijkamp, Szabolcs Fatrai, Inne H.M. Borel Rinkes, Onno Kranenburg
Publikováno v:
Annals of surgery. 259(4)
Objective: To assess the contribution of hypoxia and bone marrow–derived cells to aggressive outgrowth of micrometastases after liver surgery. Background: Liver surgery generates a microenvironment that fosters aggressive tumor recurrence. These ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f25157de38c12f3258bd804222a355
https://pubmed.ncbi.nlm.nih.gov/24253142
https://pubmed.ncbi.nlm.nih.gov/24253142
Autor:
Frederik J H, Hoogwater, Nikol, Snoeren, Maarten W, Nijkamp, Amy C, Gunning, Winan J, VAN Houdt, Menno T, DE Bruijn, Emile E, Voest, Richard, VAN Hillegersberg, Onno, Kranenburg, Inne H M Borel, Rinkes
Publikováno v:
Anticancer research. 31(12)
To assess whether circulating soluble CD95 ligand (sCD95L) levels are associated with recurrence-free survival (RFS) in patients with synchronous colorectal liver metastases.Blood samples were obtained from 62 patients with synchronous colorectal liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a20dceb3f05296a86620daeda69e4337
https://pubmed.ncbi.nlm.nih.gov/22199323
https://pubmed.ncbi.nlm.nih.gov/22199323
Autor:
Menno T, De Bruijn, Daniëlle A E, Raats, Jolien, Tol, John, Hinrichs, Steven, Teerenstra, Cornelis J A, Punt, Inne H M Borel, Rinkes, Onno, Kranenburg
Publikováno v:
Anticancer research. 31(4)
The response of colorectal tumours to chemotherapy is highly variable. Preclinical work has shown that the Kirsten ras (KRAS) oncogene sensitizes colorectal tumour cells to oxaliplatin and capecitabine in a wild-type tumour suppressor p53 (TP53)-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29d1e8bc63e06b9454b825c7fb479dfe
https://pubmed.ncbi.nlm.nih.gov/21508389
https://pubmed.ncbi.nlm.nih.gov/21508389
Autor:
Onno Kranenburg, Menno T. de Bruijn, Ernst J.A. Steller, Danielle A.E. Raats, Inne H. M. Borel-Rinkes, Benjamin L. Emmink
Publikováno v:
Cellular oncology (Dordrecht). 34(4)
Oxaliplatin is frequently used in the treatment of metastatic colorectal cancer (CRC). Our previous work shows that oxaliplatin induces the pro-apoptotic protein Noxa in CRC cells. The Bcl2-inhibitor ABT-737 is particularly effective in cells with hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37cc468f832bd5b09d3b3c5176993a36
https://pubmed.ncbi.nlm.nih.gov/21468686
https://pubmed.ncbi.nlm.nih.gov/21468686
Autor:
Menno T. de Bruijn, Mike H. Teo, Robert Padbury, Greg J. Barritt, Vincent B. Nieuwenhuijs, Tom Callahan, Mathilde Steenks, Marc Schiesser, Mark C.P.M. Van Baal
Publikováno v:
Hpb, 12(4), 250-261. ELSEVIER SCI LTD
Background: Ischaemic preconditioning (IPC) and intermittent ischaemia (INT) reduce liver injury after ischaemia reperfusion (IR). Steatotic livers are at a higher risk of IR injury, but the protection offered by IPC and INT is not well understood. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a201dd4685878064f20476f330ee9c9
https://research.rug.nl/en/publications/83233a25-1cdf-48b3-9e03-d6cea8af43b5
https://research.rug.nl/en/publications/83233a25-1cdf-48b3-9e03-d6cea8af43b5
Autor:
Martin R. Sprick, Menno T. de Bruijn, Maarten W. Nijkamp, B. Florien Westendorp, Ernst J.A. Steller, Onno Kranenburg, Inne H.M. Borel Rinkes, Jan Paul Medema, Niels Smakman, Henning Walczak, Danielle A.E. Raats, Frederik J.H. Hoogwater, Ron C. J. Schackmann, Patrick W. B. Derksen, Winan J. van Houdt, Uta Schaefer, Benjamin L. Emmink
Publikováno v:
Gastroenterology, 138(7), 2357-2367. W.B. Saunders Ltd
Background & Aims Death receptors expressed on tumor cells can prevent metastasis formation by inducing apoptosis, but they also can promote migration and invasion. The determinants of death receptor signaling output are poorly defined. Here we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2408cddb64e5be84893e025e7489226
https://pubmed.ncbi.nlm.nih.gov/20188103
https://pubmed.ncbi.nlm.nih.gov/20188103