Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Menno P J de Winther"'
Autor:
Suzanne A B M Aarts, Myrthe E Reiche, Myrthe den Toom, Linda Beckers, Marion J J Gijbels, Norbert Gerdes, Menno P J de Winther, Esther Lutgens
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202150 (2018)
Obesity is a low-grade inflammatory disease that increases the risk for metabolic disorders. CD40-CD40L signaling plays a central role in obesity-induced inflammation. Genetic deficiency of CD40L in diet-induced obesity (DIO) ameliorates adipose tiss
Externí odkaz:
https://doaj.org/article/d814a689b6b64c32bf5208ea8e8a55b6
Autor:
Iris E Allijn, Stefan F C Vaessen, Linda C Quarles van Ufford, Kees J Beukelman, Menno P J de Winther, Gert Storm, Raymond M Schiffelers
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155325 (2016)
Inflammation is an important therapeutic target. Due to their potency, steroidal drugs dominate the current treatment of inflammatory disorders. However, steroidal drugs can also exert a broad range of side effects and appear not always effective. Th
Externí odkaz:
https://doaj.org/article/79f4248a165e48ffb801dd07a772cae0
Autor:
Virginia Smit, Jill de Mol, Mireia N. A. Bernabé Kleijn, Marie A. C. Depuydt, Menno P. J. de Winther, Ilze Bot, Johan Kuiper, Amanda C. Foks
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Background Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaque formation. It is w
Externí odkaz:
https://doaj.org/article/b14e5b874ade4e8180fc0cb6e3004836
Autor:
Pathricia V Tilstam, Marion J Gijbels, Mohamed Habbeddine, Céline Cudejko, Yaw Asare, Wendy Theelen, Baixue Zhou, Yvonne Döring, Maik Drechsler, Lukas Pawig, Sakine Simsekyilmaz, Rory R Koenen, Menno P J de Winther, Toby Lawrence, Jürgen Bernhagen, Alma Zernecke, Christian Weber, Heidi Noels
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87452 (2014)
BackgroundThe Ikkα kinase, a subunit of the NF-κB-activating IKK complex, has emerged as an important regulator of inflammatory gene expression. However, the role of Ikkα-mediated phosphorylation in haematopoiesis and atherogenesis remains unexplo
Externí odkaz:
https://doaj.org/article/4c1509550b444460abf7231c1a2b2fe3
Autor:
Nadine Jetten, Nadia Roumans, Marion J Gijbels, Andrea Romano, Mark J Post, Menno P J de Winther, Rene R W J van der Hulst, Sofia Xanthoulea
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102994 (2014)
Macrophages play a crucial role in all stages of cutaneous wound healing responses and dysregulation of macrophage function can result in derailed wound repair. The phenotype of macrophages is influenced by the wound microenvironment and evolves duri
Externí odkaz:
https://doaj.org/article/bb4f07f96e634049827191034300ae28
Autor:
Karolina A P Wijnands, Marten A Hoeksema, Dennis M Meesters, Nynke M S van den Akker, Daniel G M Molin, Jacob J Briedé, Mitrajit Ghosh, S Eleonore Köhler, Marc A M J van Zandvoort, Menno P J de Winther, Wim A Buurman, Wouter H Lamers, Martijn Poeze
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86135 (2014)
Arginase-1 is an important component of the intricate mechanism regulating arginine availability during immune responses and nitric oxide synthase (NOS) activity. In this study Arg1(fl/fl)/Tie2-Cre(tg/-) mice were developed to investigate the effect
Externí odkaz:
https://doaj.org/article/9fa4e27db8cb47fea88c99f8eca25494
Autor:
Mariëtte R Boon, Sjoerd A A van den Berg, Yanan Wang, Jan van den Bossche, Sofia Karkampouna, Matthias Bauwens, Marijke De Saint-Hubert, Geertje van der Horst, Slobodan Vukicevic, Menno P J de Winther, Louis M Havekes, J Wouter Jukema, Jouke T Tamsma, Gabri van der Pluijm, Ko Willems van Dijk, Patrick C N Rensen
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74083 (2013)
Background/aimsBrown adipose tissue (BAT) dissipates energy stored in triglycerides as heat via the uncoupling protein UCP-1 and is a promising target to combat hyperlipidemia and obesity. BAT is densely innervated by the sympathetic nervous system,
Externí odkaz:
https://doaj.org/article/ffe1798349a646ec9e836dd6d43dd936
Autor:
Marcella van Leeuwen, Michael J Kemna, Menno P J de Winther, Louis Boon, Adriaan M Duijvestijn, Darius Henatsch, Nico A Bos, Marion J J Gijbels, Jan Willem Cohen Tervaert
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68039 (2013)
AIMS: New strategies to overcome complications of cardiovascular diseases are needed. Since it has been demonstrated that atherosclerosis is an inflammatory disease, modulation of the immune system may be a promising approach. Previously, it was sugg
Externí odkaz:
https://doaj.org/article/7c26904ce5e248e2bb3683821cc298ad
Autor:
Nadine Jetten, Marjo M P C Donners, Allard Wagenaar, Jack P M Cleutjens, Nico van Rooijen, Menno P J de Winther, Mark J Post
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68811 (2013)
AIMS: Enhancement of collateral development in coronary or peripheral artery disease is a therapeutic target, but it has proven difficult to achieve. Macrophages are key players in collateral remodeling, yet the effect of different macrophage subsets
Externí odkaz:
https://doaj.org/article/94927005c0c5490ea15e4ef9d12ded53
Autor:
Kristiaan Wouters, Céline Cudejko, Marion J J Gijbels, Lucia Fuentes, Kadiombo Bantubungi, Jonathan Vanhoutte, Rebecca Dièvart, Charlotte Paquet, Emmanuel Bouchaert, Sarah Anissa Hannou, Florence Gizard, Anne Tailleux, Menno P J de Winther, Bart Staels, Réjane Paumelle
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32440 (2012)
ObjectiveA genomic region near the CDKN2A locus, encoding p16(INK4a), has been associated to type 2 diabetes and atherosclerotic vascular disease, conditions in which inflammation plays an important role. Recently, we found that deficiency of p16(INK
Externí odkaz:
https://doaj.org/article/f1eb7ebaa8ee485b9bc67339bc01578d