Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Menno P, Creyghton"'
Autor:
Bas Castelijns, Mirna L. Baak, Ilia S. Timpanaro, Caroline R. M. Wiggers, Marit W. Vermunt, Peng Shang, Ivanela Kondova, Geert Geeven, Valerio Bianchi, Wouter de Laat, Niels Geijsen, Menno P. Creyghton
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
The understanding of the changes regulating gene expression relevant for the emergence of the human brain and its susceptibility to disease is limited. Here, the authors identified a set of regulatory elements that evolved in hominins affecting oligo
Externí odkaz:
https://doaj.org/article/82266434e4204259b6a7fa449dc212bd
Autor:
Shilu Amin, Roel Neijts, Salvatore Simmini, Carina van Rooijen, Sander C. Tan, Lennart Kester, Alexander van Oudenaarden, Menno P. Creyghton, Jacqueline Deschamps
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3165-3177 (2016)
In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants
Externí odkaz:
https://doaj.org/article/4ab8ee6139bb4f9fa7f97daeb5e5aefe
Autor:
Caroline R.M. Wiggers, Mirna L. Baak, Edwin Sonneveld, Edward E.S. Nieuwenhuis, Marije Bartels, Menno P. Creyghton
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2866-2877.e5 (2019)
Summary: Relapse in acute myeloid leukemia (AML) may result from variable genetic origins or convergence on common biological processes. Exploiting the specificity and sensitivity of regulatory DNA, we analyze patient samples of multiple clinical out
Externí odkaz:
https://doaj.org/article/4ddac489f2b645c6b704215a8032921b
Autor:
Anita M.A.P. Govers, Caroline R.M. Wiggers, Ruben van Boxtel, Michal Mokry, Edward E.S. Nieuwenhuis, Menno P. Creyghton, Marije Bartels, Paul J. Coffer
Publikováno v:
HemaSphere, Vol 3, Iss 4 (2019)
Abstract. The clinical use of histone deacetylase inhibitors (HDACi) for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last decades. Nonetheless, their effects on normal myelopoiesis remain po
Externí odkaz:
https://doaj.org/article/36797ea773fd43cdb616f8e9d2716fc3
Autor:
Lotte C. Houtepen, Christiaan H. Vinkers, Tania Carrillo-Roa, Marieke Hiemstra, Pol A. van Lier, Wim Meeus, Susan Branje, Christine M. Heim, Charles B. Nemeroff, Jonathan Mill, Leonard C. Schalkwyk, Menno P. Creyghton, René S. Kahn, Marian Joëls, Elisabeth B. Binder, Marco P. M. Boks
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Exposure to childhood trauma is a major risk factor for the development of almost all psychiatric disorders. By epigenome-wide studies, here, Houtepen et al. show that DNA methylation at a locus in the Kit ligand gene (KITLG) mediates the relationshi
Externí odkaz:
https://doaj.org/article/8d086f36e6654c299d12aa96eafaf3c5
Autor:
Janneke G.C. Peeters, Stephin J. Vervoort, Sander C. Tan, Gerdien Mijnheer, Sytze de Roock, Sebastiaan J. Vastert, Edward E.S. Nieuwenhuis, Femke van Wijk, Berent J. Prakken, Menno P. Creyghton, Paul J. Coffer, Michal Mokry, Jorg van Loosdregt
Publikováno v:
Cell Reports, Vol 12, Iss 12, Pp 1986-1996 (2015)
The underlying molecular mechanisms for many autoimmune diseases are poorly understood. Juvenile idiopathic arthritis (JIA) is an exceptionally well-suited model for studying autoimmune diseases due to its early onset and the possibility to analyze c
Externí odkaz:
https://doaj.org/article/c1cd1e2fa1d44680972416383a34d42e
Autor:
Marit W. Vermunt, Peter Reinink, Jeroen Korving, Ewart de Bruijn, Paul M. Creyghton, Onur Basak, Geert Geeven, Pim W. Toonen, Nico Lansu, Charles Meunier, Sebastiaan van Heesch, Hans Clevers, Wouter de Laat, Edwin Cuppen, Menno P. Creyghton
Publikováno v:
Cell Reports, Vol 9, Iss 2, Pp 767-779 (2014)
Understanding the complexity of the human brain and its functional diversity remain a major challenge. Distinct anatomical regions are involved in an array of processes, including organismal homeostasis, cognitive functions, and susceptibility to neu
Externí odkaz:
https://doaj.org/article/f2a52140da1e424a8aff2a3ac40ccfd4
Autor:
John J. Ely, Alexey Kozlenkov, Michael Wegner, Marit W. Vermunt, Ke Hao, Patrick R. Hof, Eugene V. Koonin, Chet C. Sherwood, Jun-Hao Li, Eran A. Mukamel, Stella Dracheva, Pasha Apontes, Menno P. Creyghton
Publikováno v:
Proceedings of the National Academy of Sciences of the U.S.A., 117(45), 28422-28432. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 45
Proceedings of the National Academy of Sciences of the United States of America
Significance The cerebral cortex of the human brain is a highly complex, heterogeneous tissue that contains many cell types that are exquisitely regulated at the level of gene expression by noncoding regulatory elements, presumably in a cell-type–d
Autor:
Frederik M. A. van Schaik, H. Th. Marc Timmers, Ann M. Graybiel, Jill R. Crittenden, Benjamin J. Blencowe, Martin L. Biniossek, Mercedes M Ondik, Julia Mitschke, Thomas Reinheckel, Nadja Stöffler, Manuel Irimia, Oliver Schilling, Simona Capponi, Lisa Lehmann, Marit W. Vermunt, Menno P. Creyghton
Publikováno v:
Taylor & Francis
Neuronal microexons represent the most highly conserved class of alternative splicing events and their timed expression shapes neuronal biology, including neuronal commitment and differentiation. The six-nt microexon 34' is included in the neuronal f
Autor:
Karen Grütz, Mark Angelo C. Ang, Menno P Creyghton, Christine Klein, G. Paul Legarda, Cara Fernandez-Cerado, Sheikh Nizamuddin, Peter De Rijk, Cid Czarina E. Diesta, Simona Capponi, Edwin L Muñoz, Nadja Stöffler, H. T. Marc Timmers, M. Salvie Velasco-Andrada, Marit W Vermunt, Bas Castelijns, D. Cristopher Bragg, Ellen B. Penney
Publikováno v:
Brain communications
Brain Communications
Brain Communications
X-linked dystonia-parkinsonism (XDP) is a monogenic neurodegenerative disorder of the basal ganglia, which presents as a combination of hyperkinetic movements and parkinsonian features. The underlying genetic mechanism involves the insertion of a SIN